Barely Significant

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514,629 sentences

failed to reach significancep = 0.00140.0× alpha
There was a trend towards a greater number of rare homoplasmic point mutations in two genes in AD compared to controls; MT-RNR1 (AD; 30/282 (10.6%), Controls; 16/344 (4.7%)) ( p = 0.005)) and again MT-TR (AD; 6/282 (2.1%), Controls; 0/344) ( p = 0.008), although both failed to reach significance at the corrected threshold of p = 0.0014.
highly significantP = 0.00140.0× alphaqualifiedgold
At 705 nm, the overall temporal trajectory across all time points was significant (χ 2 = 13.20, P = 0.040, n = 6 animals), and the decline phase from 6 to 24 hours was highly significant (χ 2 = 12.56, P = 0.0014, n = 6 animals), with the 6- to 24-hour decrease confirmed by paired Wilcoxon test ( P = 0.031) and paired t test ( P = 0.003) (table S1).
highly significantp = 0.00140.0× alphaqualifiedgold
On the other hand, inoculated plants expressed a highly significant and positive correlation (R = 0.6, p = p = 0.0014** ) between the inorganic “Pi” content and total P, indicating that PSB isolates likely contribute to a better internal P use efficiency ( Figure 2B ).
highly significantp = 0.00140.0× alphaqualifiedgold
Analysis of the concatenated uidA and mutS data with MULTILOCUS yielded highly significant but low θ values when comparing isolates from the Roodeplaat dam catchment with those from the Rietvlei dam catchment ( θ = 0.012 , p = 0.0014) or when comparing phylogroup B2 isolates from the two catchments ( θ = 0.031 , p = 0.0104).
highly significantp = 0.00140.0× alphaqualifiedgold
The difference between the best versus worst LVepi site was highly significant (p = 0.0014) as it was for best versus worst LVendo (p = 0.0002).
nominally significantp -value = 1.4 × 10 −30.0× alphagold
Rs3745842 major allele (G) was more frequent in cases compared to controls, although the association was nominally significant after multiple testing correction ( p -value = 1.4 × 10 −3 , corrected p -value = 0.081) ( Supplementary Table 6 ). 3.2 LoF mutations in ABCA7 LoF mutations in ABCA7 have been recently reported as main mechanism explaining the GWAS signal and the increased susceptibility to AD.
Protein episcores and CRC overall survival In Cox regression models adjusted for age at diagnosis, the Protein EpiScores for LGALS3BP and VEGFA appeared associated with higher mortality risk, but these associations did not reach statistical significance after adjustment for multiple comparisons (LGALS3BP, HR: 1.61, 95% CI 1.20, 2.15, P = 0.0014, FDR = 0.15; VEGFA, HR: 1.62, 95% CI 1.20, 2.19, P = 0.0016, FDR = 0.17) (Fig. 3 ).
highly significantp=0.00140.0× alphaqualifiedgold
The data, quantified in Figure 4B, demonstrates a highly significant, age-dependent increase in nuclear H3K9me3 integrated density in control OPNs (p=0.0014), an effect that was completely abrogated in aged flies with OPN-specific knockdown of dSetdb1 (p>0.9999).The consistency between the global changes observed in whole-head lysates (Figure 2A) and the specific, quantitative changes measured within the relevant neuronal nuclei (Figure 4B) provides strong, convergent evidence for our conclusion that dSetdb1 mediates an age-dependent increase in H3K9 trimethylation.