Excerpts

For males, age, smoking status, and pack-years were highly significant independent risk factors for all outcomes (p < 0.002).

Among the Maya, the association between the PSS score and hot flashes approached significance ( p = 0.002).

ITS demonstrated a significant trend toward higher MED prescription per ED visit during the pandemic (coefficient 0.11, 95% CI 0.05–0.16, P = 0.002).

In the late cluster, we observed effects in similar directions: While enhanced negative compared to neutral brain activity following rDLPFC inhibition failed to reach significance, negative images elicited reduced amplitudes from Pre-cTBS to Post-cTBS in the Active Control condition [ F (1,36) = 13.595, p = 0.002].

Compared to those of the control group, the eyes of MS patients showed a highly significant reduction in RNFL thickness over time for both patients with and without ON ( P = .002 and .010, respectively) (Fig. 1 ).

A significant trend change was detected in the Diabetes group ( P = 0.002), and the trajectory of 5-Year MACE Survival changed from a negative slope to a positive slope.

Rearing events also showed significant or near-significant increases when analyzed separately within binned intervals (0 to 10 min, P = 0.002; 10 to 20 min, P = 0.046; 20 to 30 min, P = 0.074) ( Fig. 3 C ).

The pH value of fasting-morning urine correlated directly and significantly with potassium excretion ( R = 0.33, p = 0.02) but not with 24 h citrate levels ( R = 0.09; p = 0.58) while a highly significant correlation between potassium and citrate excretion was found ( R = 0.47, p = 0.002).

Our results showed that there is a direct and moderate relation between the expression of these two genes, so that by increasing the expression of each, the expression of the other one also increases, which is quite significant (r= 0.3, P = 0.002).

Trend analysis of the PM 10 dataset showed a decreasing trend (Modified M–K Hamed Rao approach test result: tau ( τ ) = − 0.3, p -value = 0.002) with a low rate of 0.2 μg m −3 per annum during 2018–2020 (Fig. 5 ).

CNVR correlations Of the 110 CNVR evident in more than 2 individuals, 22 loci demonstrated a significant pairwise association ( p ≤ 0.05) with at least one other loci across all 7 breeds, 11 of which demonstrated highly significant correlations ( p ≤ 0.002).

Interestingly, comparison between control tumors and shp16 methotrexate-treated tumors was highly significant both at day 30 ( P = 0.002) and at the timepoint when all shp16 mice had reach endpoint (day 55, P < 0.001), although we do note variability in this experiment ( Supplementary Fig.

We detected a significant excess of variants in two of the pathways in CVID patients when compared to controls: Fc epsilon RI signaling and cytokine–cytokine receptor interaction pathways ( P < 0.001 and 0.002, respectively), plus two other marginally significant pathways after applying multiple test correction: cytosolic-DNA sensing, and NFKB signaling ( P = 0.002 and 0.001, respectively).

CD4/CD8 ratio showed a highly significant difference between all groups; p = 0.002.

Higher Tau levels correlated with higher SLEDAI-2K at study visit (r=0.40, p=0.002) and AMS over the disease duration (r=0.49, p=0.002), although these did not reach statistical significance for a corrected p value <0.002.

Territorial distribution of cMBs The Jonckheere-Terpstra trend test (with number of 1000 permutations), showed a significant trend (JT = 357, p = 0.002) towards if both vascular territories were affected.

Interestingly, age was a highly significant ( P = 0.002) predictor in this model, so that there was a 20% expected increase in carriage count per increased year of age.

Gender was found to be a marginally significant predictor of device adoption, with male respondents adopting VR devices later than female respondents (β = 0.113, p = .002). 5 Age was also a factor, as older respondents reported adopting VR devices earlier (β = −0.096, p = .009).

In the RR-MS group, severity of fatigue, after controlling for depression symptoms, was associated with heightened role of the left amygdala within the entire brain network (indicated by a marginally significant positive association of betweenness centrality of this region with fatigue ratings: r =.561, p =.002).

The effect of DNMT3A genotype on birth weight and DNMT3B on length of gestation were the least significant before the exclusion and just below significance following the reduction in numbers; though the stronger DNMT3B effect on risk of prematurity remained highly significant (p = 0.002) after exclusion of the non-Caucasian pregnancies.

Even though fluency covariates substantially degraded the main effects of the factor of Group for dual-tasking energy costs, the corrected effects still remained robust and highly significant [AMT: F (1,49) = 10.315, p < 0.002; MMT: F (1,49) = 9.522, p < 0.003].

By independently comparing the number of lengthening and shortening genes with differential expression changes to those genes without associated expression changes, we observed a higher than expected overlap between genes with both 3′ UTR lengthening and increased expression, and a barely significant overlap between 3′ UTR shortening and decreased expression ( p = 0.002 and p = 0.02, two-sided Fisher’s exact test, Bonferroni correction).

In a later analysis of a smaller ( n = 356) subsection of the cohort with more complete data (18% missing LA Z-scores), the hazard ratio was lower, 1.03, and not statistically significant (whereas in contrast maximal wall thickness Z-scores hazard ratio 1.07 remained highly significant, p = 0.002).

Stratification by age‐groups (Table 1 ) showed a significant decline by 14·7% (from 54·7% to 40%) in the youngest age‐group (0–9 year, P = 0·0394), a highly significant decline ( P = 0·0020) of 10·3% (from 20·8% to 10·5%) in age‐group 50–79, a non‐significant decline ( P = 0·1797) of 13·6% (from 46·3% to 32·7%) in the oldest age‐group (>80 year), and very modest decline in age‐groups 10–19 (3·5%, from 60·9% to 57·4%; P = 0·5989) and 20–49 (3·7%, from 30·1% to 26·4%; P = 0·3740).

The difference between the irradiated and non-irradiated group was highly significant ( P = 0.002).