Excerpts

CSF 14-3-3 levels showed a significant trend of being higher in patients who had a shorter duration from symptom onset to death ( R 2 = 0.71, F = 19.55, P = .0022; Supplementary Figure 1 ).

We recorded a slight trend towards fewer heterozygote delta F508 carriers (p=0·0022), more people with no delta F508 genes (p<0·0001), and a greater proportion of non-white patients with increasing level of deprivation (p<0·0001).

These effects could also be validated in HUVECs in vitro, as cells overexpressing miRNA-26b show a highly significant ( p = 0.0022) twofold induction of Cx40 transcription, compared to cells transfected with a non-coding siRNA (siNC) ( Figure 1 b).

sporotrichioide s was also demonstrated by a highly significant ( P = 0.0022) negative linear regression of SCIRP contents against culture age during the period of 35–56 days after inoculation.

Indeed, analyzing the joint data set revealed a highly significant correlation between H corr and behavioral performance (r = 0.75, p < 0.0022, see Fig. 6 B).

There was a significant trend that the longer the duration of ACEI/ARB, the higher log [Calc/BSA] ( P = 0.0022) with Jonckheere-Terpstra trend test.

Unexpectedly, a highly significant ( P = 0.0022) increased frequency of naive B cells in the peripheral blood of healthy controls (HCs) compared with patients with RA was observed ( Figure 1B ).

This decrease was highly significant in the naive group (N-peptide, p = 0.0022, R-, p = <0.0003, and C-, p = 0.0367) whereas it was non-significant in the semi-immune group (N-peptide, p = 0.902, R- p = 0.263, and C-, p = 0.371) (Fig. 4 ).

In the EUR GWAS for Aβ, we found that rs76490923 had a marginally significant association (beta = −0.1240, SE = 0.0404, p = 2.20 × 10 −3 ) with Aβ in EUR population. rs76490923 was associated with decreased Aβ levels and exhibited the same effect directionality (beta coefficient, −0.1240 [EUR] vs. −0.1661 [EAS]) as in our EAS GWAS results (Fig. 2 ).

In a positive/negative thresholded analysis, without taking into account expression level in the positive patients, channel expression did not add predictive value over age alone in the elderly and mid-age patients (older than 65 and 17.28 to 65 years; p = 0.59 and 0.44), but was still highly significant as a bad prognostic factor in young patients (p = 0.0022).

Transplantation showed a trend toward improvement in intestinal tissue damage and a decrease in inflammatory cell infiltration (loss of epithelium: p=0.0022, crypt damage: p=0.0087, depletion of goblet cell: p=0.0433, histological score: p=0.0043) ( Fig. 3E ).

These directional changes were highly significant (LME: F = 6.12, p = 0.0022).

In particular, the reaction time had a highly significant effect ( p -value = 0.0022), confirming its strong influence on the degree of substrate surface phosphorylation.

Non-parametric statistical analysis using the Kruskal–Wallis test resulted in highly significant ( p = 0.00223, p < 0.01) differences between the three groups of genotypes with their HFP measurements.

We observed a significant trend ( P =2.28 × 10 −3 , Figure 1 right panel) in that the strength of association of the individual SNPs with TSMC (measured by the regression coefficient) tended to be larger for those with larger reported odds ratio of association with breast cancer risk, but this trend was largely influenced by SNP rs11814448 in DNAJC1 ( P =0.37 when excluding SNP rs11814448).

The interaction was highly significant with F(4,76) = 4.58, p < .0023 and F(4,76) = 4.55, p < .0024 for Exp1 and Exp2, respectively.

We observed a nominally significant association with 2 HLA alleles: HLA-A*23:01 (OR=1.04, p=2.3x10 -3 ) and HLA-C*06:02 (OR=1.04, p=1.5x10 -3 ).

Based on the Cox PH model analysis, the difference between treatment and control groups was highly significant with p = 0.0023 (one-sided), adjusting for disease status at randomization.

We observed a highly significant difference in the frequency of stenoses between 30% and 50% DS between the PAPS group ( n = 24) and the control group ( n = 7) (CI95: 0.59–0.90, p = 0.0023), as well as the SAPS group ( n = 30) (CI95: 0.65–0.92, p = 0.0002).

We found that the parent-of-origin effect was highly significant overall ( p = 0.0023) and was consistent in its direction, magnifying XCI skewing in the F1 female hybrids inheriting the stronger Xce allele from their mothers ( Figure 6 ).

At week 12, these increases were dose‐dependent and were significant for solriamfetol 300 mg (84.7%) and 150 mg (78.2%) doses versus placebo (39.7%; both p < 0.0001); the 75 mg dose was nominally significant (67.8%) compared with placebo ( p = 0.0023, but the comparison was below the hierarchical break).

After correcting for multiple testing, genetic effects were highly significant regardless of whether TBV was included as a covariate ( p value < 0.0023), while shared environmental effects were not significant for any ROI for either model.

11 , where P < 0.05 is nominally significant; specific area significance (i.e., Specific brain thickness P < (0.05)/(11 traits*2 SNPs) = P < 0.0023.

( 2020 ) furnished positive correlations between intramuscular fat% and flavor intensity approaching significance ( r = 0.33, p = 0.0023).

The trend was highly significant ( p = 0.0023).