Excerpts

Moreover, an increasing trend toward liver steatosis severity was observed in patients with BMI ≥ 25 kg/m 2 (Cochran Armitage trend test = 3; p = 0.0027).

The robustness of these observations is confirmed by the test for subgroup differences, which is highly significant ( p = 0.0027) (Fig. 6 ).

Both male and female mice showed a trend towards higher alpha-diversity with SCFA treatment, with male mice reaching statistical significance at the taxonomic levels of order ( p = 0.0027), class ( p = 0.0027) and phylum ( p = 0.043) and female mice reaching significance at the genus ( p = 0.049) taxonomic level ( Figures 2A,C , p -values for all taxonomic levels in Table 1 ).

Although no CPG showed significant enrichment after FDR adjustment, BRCA1 showed the highest frequency of P/LP carriers in NB patients (N = 7, 1.05%) and yield a nominally significant enrichment (Firth's logistic regression P = 2.7 × 10 −3 , OR = 18.76) as well as BRCA2 (N = 4, 0.060%, Firth's logistic regression P = 0.032, OR = 11.21) ( Fig. 2 b, Table 2 , Table S11 ).

A highly significant increase ( p = 0.0027, Welch’s two sample t -test) in the length of actin microfilaments was detected with a reduction in the cell thickness ( p = 0.0162, Welch’s two sample t -test) of MCF7 cells that induced K16 compared to control cells ( Figure 3 H,I).

Response When the 57 EGFR -mutant NSCLC patients of the training cohort were grouped as erlotinib responders and non-responders according to BIM mRNA expression, a clear trend emerged: 88.9% of patients with high BIM mRNA expression responded to erlotinib vs 22.2% of patients with low/intermediate BIM levels ( P = 0.0027).

The interaction between time and treatment effects on urinary free FB 1 was linear and highly significant (p = 0.0027 in the low-dose group and p = 0.0006 in the high-dose group).

Conversely, a highly significant ( P = 0.0027) increase in mortality rate was observed following treatment with the ICL-inducing agent MMC in Merit40 −/− mice when compared with wild-type littermate controls ( Fig. 1 E).

The most strongly associated SNP (rs804279) was intergenic, approached genome-wide significance in the Stage 1 Discovery GWAS (A allele, OR=0.74, 0.66–0.83 95%CI, logistic regression P =1.4 × 10 −6 ), and was nominally significant in the Stage 2 Metabochip Replication (A allele, OR=0.82, 0.73–0.93 95%CI, logistic regression P =2.7 × 10 −3 ) for a sample-size weighted two-strata meta-analysis P meta =1.9 × 10 −8 .

Nominally significant effects were found in four gene sets causing inferior outcomes at posttreatment: intracellular signal transduction (large size CNVs: β = 0.204, P = 0.0027; clinically significant CNVs: β = 0.202, P = 0.0029), cell adhesion and trans-synaptic signaling (large size CNVs: β = 0.255, P = 0.0071; clinic

FGFR4 expression, was detectable only in 6 of 81 patients (7.4%) and showed a highly significant correlation with a shorter OS (P = 0.0027). 3.3.

Statistical analysis by Spearman’s rank test revealed a highly significant inverse correlation between the TTV DNA change and the pre-transplant level (r = -0.61; P = 0.0027; Fig 3B ).

For the response variable Y 1 (Flexural Strength), the nano-silicate factor ( X 1 ) was found to be highly significant ( p = 0.00279), while the other factors showed no statistically significant effects.

For example, Pignol et al 3 found a highly significant correlation between the development of moist desquamation, an increase in reported breast symptoms ( P = .0028), and patient-defined pain score on a visual analog scale ( P < .0001).

However, L139* was almost significant in the Benjamini-Hochberg procedure (threshold P value: 1/20 × 0.05 = 0.0025; t -test result: t 4 = 6.565, P = 0.0028), suggesting this decrease in TEM messenger level might be real.

There was a significant trend between ellipsoid zone appearance and ability to quantify AOSLO ( P = 0.0028).

The differences in slope at higher I for the low R region of the PFR are highly significant ( t (75) = 3.23, p = 0.0028).

In addition, a highly significant correlation between plasma Cu, but not Zn or Cu/Zn ratio, and anti- Leishmania IgG was observed across patient groups (Fig. 2 , Spearman r = 0.65, p = 0.0028).

Association between fetal IUGR and fetal malperfusion appear highly significant ( χ 2 = 8.97, p -value = 0.0028) underlying the crucial role of placental disorders in fetal growth defects due to chronic fetal hypoxia.

Intriguingly, the amount of protein carbonylation in the different lysate preparations showed a highly significant linear correlation with the percentage of long-term surviving mice (R 2 = 0.96, p = 0.0028, Fig. 5C ).

An increasing trend in the prevalence of NCDs was witnessed with the increasing age of subject (Spearman correlation, r=0.9643; P =0.0028) ( Fig. 2 ).

With a median follow-up of 9.6 years, a highly significant decrease ( p = 0.0028) in the probability of LR was seen in the EBRT group, but no difference in OS was shown.

PRRX1 exhibited one highly significant correlation with TMEM33 ( r = − 1.000, p = 0.0028), while SLAIN2 showed significant positive correlations with PTPN2 ( r = 0.886, p = 0.033) and TMEM33 ( r = 0.943, p = 0.017).

carinatus, too, revealed highly significant differences (Kruskal–Wallis χ2 = 11.72, df = 3, p < 0.0028).

Statistical analysis revealed highly significant reductions in expression levels ( p < 0.0028 for OmpA and p < 0.0001 for Bap ), demonstrating that the combination affects biofilm formation at the transcriptional level.