Overall, the hypothesis that the number of fibre mats affects the mixing index was highly significant (p = 5.15 × 10 −8 ).
Excerpts
Pearson's linear correlation 0.804 was also highly significant (P < 5.15 × 10 −8 ).
Of particular importance, a model containing independently associated markers, BMI, age and smoking status, although highly significant ( p =5.186e-08) was only able to explain 5.2% of the overall variation in PCSK9 plasma levels in our sample, genetic information being the variable with the highest effect size in our model.
We run a GWAS Cox model, with the first 10 PCs, age, age 2 , sex, period of infection and patient series as covariates and we found one variant (rs117011822) associated with survival at P -value < 5.0 × 10 −8 (genome-wide significance level) and another one (rs7208524) nearly significant ( P -value = 5.19 × 10 −8 ).
Statistical analysis using a paired t-test confirmed that this improvement was highly significant ( p = 5.2 × 10−8), indicating a robust educational impact.
In the current study, a highly significant association was observed between the frequency of IL4 −590 SNP in 98 individuals allergic to D. pteronyssinus and 116 controls and the T/C genotype (p = 0.000000052) and the C allele (p = 0.010), suggesting a protective effect against sensitization to dust mites.
Notably, miR‐142‐3p expression is one of the miRNAs that is significantly increased by chronological age in peripheral blood [ 8 ] and an MIR142 ‐proximal genetic polymorphism (rs2632516) was borderline significant for late‐onset Alzheimer's disease in a genome‐wide association meta‐analysis ( p = 5.3 × 10 −8 ; genome‐wide significance at 5 × 10 −8 ) [ 9 ].
near statistical significanceP = 5.4 × 10 −8
There was one locus with two SNPs in proximity to each other, rs76008716 and rs57957360, which were near statistical significance ( P = 5.4 × 10 −8 ) and had not appeared in the top loci of other analyses.
rs6483495, an intronic variant of MAML2 located at 11q21, showed the borderline significant p -value (Beta = −0.14, P = 5.4 × 10 −8 ) (Fig. 2b and Table 2 ).
Indeed, the difference in k is highly significant ( p = 5.41 × 10 −8 ).
approached significancep = 5.45 × 10 −8
Similarly, a multivariate association test focused on the three RAN traits revealed a genome-wide significant association of rs17663182 ( p = 1.15 × 10 −8 ), while rs16928927 association only approached significance ( p = 5.45 × 10 −8 ).
a trend toward significanceP = 5.5 × 10 −8
However, two variants on chromosome 17 showed a trend toward significance in the Sierra Leone cohort (Table 1 and Extended Data Fig. 2e ). rs73397758 ( P = 5.5 × 10 −8 , odds ratio (OR) = 9.16) is ~350 KB (kilobase pairs) downstream of the gene CASC17 , a long non-coding RNA named for a genetic association with prostate cancer 37 , and 570 KB upstream of KCNJ2 , a potassium inwardly rectifying channel 38 . rs143130878 ( P = 1.1 × 10 −7 , OR = 6.87) resides 62,472 base pairs downstream of the gene CCT6B 39 , which is a member of the molecular chaperone (TRiC) family that has been shown to regulate the replication of arenaviruses, including LASV 40 .
showed a trendP = 5.5 × 10 −8
However, two variants on chromosome 17 showed a trend toward significance in the Sierra Leone cohort (Table 1 and Extended Data Fig. 2e ). rs73397758 ( P = 5.5 × 10 −8 , odds ratio (OR) = 9.16) is ~350 KB (kilobase pairs) downstream of the gene CASC17 , a long non-coding RNA named for a genetic association with prostate cancer 37 , and 570 KB upstream
Our strategy reveals an overall highly significant association of rs693 with MI (p=5.5×10-8) that is contrasted with a weak estimate following the traditional, sample-size-centered GWAS strategy (p=0.16) in the same sample.
However, this association is provisionally retained because the MR-PRESSO global test for pleiotropy was highly significant ( P = 5.50 × 10 −8 ), and the outlier-corrected estimate remained significant and directionally consistent with the primary IVW analysis (OR 0.41, 95% CI: 0.31–0.54).
There was a highly significant difference in GJA9 allele frequencies between PN cases and controls from the original GWAS cohort ( p < 5.5 × 10 −8 ), reflected in a difference in genotype frequencies under a dominant model ( p < 1.2 × 10 −7 ), but not a recessive model ( p < 0.05) (Table 1 ).
The OMG difference for KCNJ16 , decreased in glioblastomas, became highly significant, p = 5.532 × 10 −8 , and trends for other genes improved.
This difference is highly significant (one-tailed binomial p = 5.59 × 10 −8 ) and agrees well with previous interpretations [ 64 ], demonstrating that rates of chromosomal evolution can vary by over an order of magnitude even among closely related species.
The difference on the aggregated confusion matrix of all models of these three pathogens was highly significant ( p -value = 5.6 × 10 −8 , McNemar’s test).
An additional ANOVA examining flavor–sensory correlations revealed a highly significant association for strain Khorisa/NA/3 (H-statistic = 29.56, p = 5.60 × 10− 8 ), indicating that the production of volatile compounds such as cyclohexane, heptane, and oxalic acid substantially contributed to the improved sensory attributes.
In addition, a region on chromosome 17 showed a marginally significant signal led by a marker on the GOSR2 gene (chr17:44967530–45244074, lead variant: chr17:45013271_T_C; minor allele frequency, 15%; β=7.83; SE=1.44; P =5.6×10 −8 ).
A highly significant non-synonymous SNP was found at position 15,656,689 ( p -value = 5.61 × 10 –8 ) in an ankyrin repeat protein (Medtr2g438720), and the surrounding region contained multiple ankyrin repeat genes within 1 kb of many top SNPs ( Figure 4A and Table 2 ).
approached significancep = 5.64 × 10 −8
Two nearby SNPs, in linkage disequilibrium with rs9966620, also approached significance (rs7243626, p = 5.64 × 10 −8 , and rs7240470, p = 8.05 × 10 −7 ).
5 , 17 As expected based on published literature, 18 controls had a higher number of species than cases, although saliva species failed to reach statistical significance (151 and 38 species identified in plasma, Chi square X 2 = 29.473, p = 5.671e-08; 145 and 64 species found in serum, Chi square X 2 = 15.338, p = 8.988e-05; 90 and 44 species found in saliva, Chi square X 2 = 1.6647e-27, p = 1).
9 A previous study also reported a borderline significant association of the variant rs429358, representing the APOE ε4 locus with PD-AAO ( p = 5.69 × 10 −8 ) in a combined dataset (n = 28,568) comprising IPDGC and 23andMe datasets. 7 The study, however, suggested that the association at the locus could be an age-related effect, with a highly significant association with the age of controls ( p = 1.49 × 10 −5 ).