Excerpts

The coefficient for study arm was −12 (SEM 4.1), and the inclusion of study arm to the model was highly significant ( P = 10 −7 ), demonstrating a strong influence of the intervention on salt intake.

Our work also provides a list of 28 genes that are highly significant (p<10 −7 ) in all the three M1 stimuli and could be used as a starting point to define an agreed global M1 signature, when validated with other M1-polarizing agents ( e . g .

In contrast, the P -values between the two groups were highly significant ( P < 10 −7 ).

The test showed highly significant correlations for all four locations (C6‐r: tau = 0.52, p < 10 −7 ; C6‐l: tau = 0.52, p < 10 −7 ; C5‐r: tau = 0.53, p < 10 −7 ; C5‐l: tau = 0.50, p < 10 −6 ), confirming a statistically significant increase in the diameter with age for all four locations.

Indeed, intersecting the positively correlated genes with all genes that encode for chromatin binding proteins, or epifactors ( https://epifactors.autosome.ru/ ), showed highly significant enrichment (Fig 4B , green, 44 genes, fold‐enrichment = 2.33, P < 10 −7 , Fisher's exact test).

Similarly, while only a marginal association was seen with parasite density for ABO ( p = 0.01), a highly significant association was seen with plasma Pf HRP2 concentration ( p = 10 −7 , Fig. 2 ).

In the Mushroom dataset, unlike SIPRI, the Friedman test detected highly significant ranking differences in all five metrics (all p < 10 −7 ).

Polygenic risk score (PRS) computation SNPs of PRS include: 1) SNPs that are statistically significant or nominally significant per GWAS threshold ( p < 1.0 × 10 − 7 and p < 1.0 × 10 − 6 , respectively) and exome sequencing analysis ( p < 9.2 × 10 − 7 and p < 9.2 × 10 − 6 , respectively) [ 14 ]; 2) Index SNPs or Proxy SNPs in 1 Mb region that were statistically significantly and nominally significantly associated with bone health ( p < p value threshold and p < 0.05, respectively).

As expected, there was significant enrichment of pathways involved in ‘bacterial invasion of epithelial cells’, ‘tight junctions’, ‘cytokine-cytokine receptor interactions’ and ‘colorectal cancer’; however, we also observed a highly significant association with ‘apoptosis’ (p<10 −7 ) ( online supplementary figure 6 ).

We found that for both RT and confidence, the fixed effect of conflict was highly significant across all levels of complexity (all p <.0000001).

Between the measurements from the devices, there was a difference of 73 μm in the central zone and 43–50 μm in the parafoveal zones This difference between these absolute measurements was highly significant in all zones ( p < 1 × 10 −7 ).

Note this correlation is still highly significant ( P = 10 × 10 −8 ).

On Day 5, WT mice exhibited peak activity, with highly significant increases in total distance ( p < 1 × 10−7), rotations ( p < 1 × 10−6), and corner distance ( p < 0.0001).

3 Discussion The first significant finding derived from this study is the clear and highly significant correlation between TD and response, with a response rate of only 9.1% for patients with TD <205 Gy against 89.7% for those with TD ≥205 Gy, P <10 −7 .

The student’s t test showed that the differences in mean levels of expression in the 2 groups in arrays were highly significant; for 483-3p, p=0.0000001 and for 548e-3p = 0.0009482.

8 , highly significant effects were observed for the factors of eccentricity ( F (1,5) = 2458.257, p = 10 −7 ), and visual area ( F (1.574,7.871) = 107.981, p = 10 −5 , Greenhouse-Geisser corrected), and a significant interaction was found between these two factors ( F (3,15) = 85.102, p = 10 −8 ).

The median mutation count was lower in the H/L cohort compared to the NHW cohort, with a highly significant p -value ( p = 1.02 × 10 −7 ), suggesting potential differences in genomic instability between these populations.

For AMD, we identified one genome-wide significant locus in 18q22.2, rs12956753 (OR = 1.71, p = 3.76 × 10 −8 ), and another nearly significant locus in 15q14, rs138597498 (OR = 1.75, p = 1.02 × 10 −7 ), located near the genes DOK6 and DPH6 , respectively ( Figure 1 B).

In total, we found a significant trend of gene number decrease in these independent mangrove clades ( Fig. 2 ; Wilcoxon signed-rank test; P = 1.04 × 10 −7 ).

They were highly significant in the Dutch sample (rs12472355; OR, 1.39, CI 1.23–1.57, p = 1.05×10 −7 and rs919433; OR 1.43, CI 1.26–1.61, p 9.77×10 −9 ), and in the meta-analysis of all three samples they reached genome-wide significance ( Table 2 ).

Specifically, target genes of miR-30a-5p, miR-486-5p, miR-30c-2-5p, miR-205-5p, and miR-106b-3p whose expression levels showed a trend from healthy controls to MIBC patients displayed an over-representation in several KEGG pathways such as “Pathways in cancer_Homo sapiens” (hsa05200; adj p = 1.05 × 10 –7 ), “MicroRNAs in cancer_Homo sapiens” (hsa05206; adj p = 2.97 × 10 –7 ) and “Bladder cancer_Homo sapiens” (hsa05219; adj p = 3.38 × 10 –5 ).

GO analysis found that GO:0016236 was involved in autophagy, while KEGG analysis revealed a highly significant ( P = 1.06E-07) new pathway, hsa04216 (ferroptosis), a new cell death pattern associated with iron death.

We found a highly significant positive correlation between these 2 estimators of the pairwise V ST statistic (Pearson's test, P = 1.06e−07; supplementary fig.

Secondary Analysis of GWAS Finding In our study, the variant rs4242007 was in near-complete linkage disequilibrium ( r 2 = 0.98) with rs4074555 (chr4:57110400, C/A), which itself approached significance in the primary GWAS ( p = 1.07 × 10 −7 ).

Furthermore, data from seven studies demonstrated highly significant positive association between telomere length and spirometric measurements including FEV 1 (β=0.0455, p=1.07×10 −7 with fixed and random effects; I 2 =0%), FVC (β=0.0401, p=2.07×10 −7 with fixed and random effects; I 2 =0%), and FEV 1 /FVC (β=0.0238, p=5.27×10 −7 with fixed and random effects; I 2 =0%) 25 .