The ccRCC patients with mutated BAP1 showed a trend towards higher AJCC stage ( P =0.006), pathologic T stage ( P =0.009), Fuhrman grade ( P =0.003) and distant metastasis ( P =0.029) compared with those with wild-type BAP1 ( Table 1 ).
Moran's test detected highly significant but weakly positive spatial autocorrelation (Moran statistic I = 0.08, p = .006), meaning that neighboring sites tended to display similar temporal trends.
In contrast, there was a highly significant drop in stop rates when performing this analysis for sites in the TRMT6/61A group as a control (Paired T -test, P = 0.006) ( Fig. 2 B, right panel).
Second, stratifying the cohort by the clinical eGFR cut-off of 60 mL/min/1.73 m 2 revealed a clear moderating effect: the GMV reduction in the CI group was not significant in patients with eGFR ≥60 mL/min/1.73 m 2 (P=0.148) but was highly significant in those with eGFR <60 mL/min/1.73 m 2 (P=0.006; Table S3 ).
At the Bonferroni-corrected alpha level of 0.004, energy and catastrophizing were the only variables showing significant pre-post changes, with pain acceptance and general health approaching significance ( p = 0.006 and p = 0.005, respectively).
The difference in verbalisation between the groups in the unfamiliar Required Social Interaction condition approached significance ( p = .006).
Applicants identifying as female had a highly significant reduction in the odds of receiving an offer of a national training number compared with male counterparts (aOR=0.44, 95% CI 0.25 to 0.79, p=0.006) ( table 2 ).
The rs714939 SNP was also the only marker that showed a trend for association with PIQ (P = 0.006).
LIC showed a trend similar to that of serum ferritin—we observed a significant decrease over time, considering the whole group and the patients with good compliance ( p = 0.006) but not those with poor compliance (0.7).
Baseline demographic and clinical characteristics were well balanced between the SCDM-DHM group and the control group ( p > 0.05), with no statistically significant differences observed in terms of maternal age, birth weight, gestational age, number of males, delivery mode, SGA status, or length of hospital stay; a decreasing trend in the number of single births was observed in the SCDM-DHM group ( p = 0.006).
In the study on major knee surgery ( Bauer et al 2001 ) the frequency of major bleeding complications was 2.1% in the fondaparinux group vs 0.2% in the enoxaparin group, a difference which was highly significant (p<0.006).
Merging the ten subjects resulted in a highly significant improvement in SRT50 ( P = 0.006).
As shown in Table 1 , the characteristics that showed a significant trend across SOFA tertiles were mean blood pressure values ( P = 0.006), need of vasopressors for hemodynamic support ( P < 0.001), need for MV ( P < 0.001), the time from symptom onset to ICU admission ( P = 0.014), and treatment with tocilizumab ( P = 0.013).
A highly significant ( p = 0.006) association of high E-Cadherin expression (median rank: 40.18) and negative estrogen receptor status was observed.
Univariate analyses for CIMT progression as an ordinal (tertile) variable yielded a significant trend for increasing CIMT progression tertile with greater concentrations of fasting glucose ( P = 0.006) and a significant trend for less CIMT progression higher baseline CIMT ( P < 0.001).
Differences in growth rates between resource concentrations were larger in high temperature (Figure 2b ): In high temperature, all pairwise tests between different resource concentrations were clearly significant ( p < 0.006) except 0.05× vs. 0.1× ( p = 0.203) and 1× vs. 2× ( p = 0.999).
The differences did not reach statistical significance after Bonferroni adjustment (p = 0.006).
Indeed, the two-way ANOVA showed a highly significant main effect of perceptual response [ F (1, 17) = 10.19, p < 0.006, η 2 p = 0.38], with greater P2 amplitude on streaming trials (streaming, 3.75 ± 0.70 μV; bouncing, 3.10 ± 0.74 μV).
Although group differences in total lung iNOS+ expression (including TBLs) did not reach statistical significance (Figure 3 B), in nonimmunized goats this marker correlated strongly with both gross ( r > 0.81, p = 0.006) and microscopic lesion scores ( r > 0.77, p = 0.010).
Age, best-corrected visual acuity, and intraocular pressure did not differ significantly between RP patients and healthy controls ( P > 0.05), whereas there was a highly significant difference with regard to visual field parameters, MD ( P < 0.006) and PSD ( P < 0.001) and ERG; indeed, RP had peripheral visual field defects and decreased b-wave and a-wave amplitude compared to controls ( P < 0.002 and P < 0.019, resp.).
Thus, marginally significant results (e.g., IL-6 − 174 G/C, p = 0.006) may not survive Bonferroni correction but could remain significant under FDR depending on the overall p-value distribution.
The difference between groups A and B was statistically highly significant ( p = 0.006).
1 – 3 ), the EEFBs removed almost 53.1% ± 1.13% of the TN with a concentration of up to 6.56 ± 0.20 mg L −1 , and the net removal rate of EEFBs and EFBs were 40.9% ± 1.13% and 14.5% ± 1.19%, which represent a markedly significant difference in the TN removal ( p = 0.006).
Based on our primary AUC analysis, the only cytokine that differed significantly as a function of anesthetic approach was IL-6, and the increase was only marginally statistically significant ( P = 0.006 with an α threshold of 0.01 because of multiple comparisons).
SNPs were deemed replicated in MVP TOT if they had matching effect direction and were nominally significant after Bonferroni correction for the 9 SNPs tested ( p < .006).