Excerpts

This differ- ence is highly significant (P<0-01) al- though this method of analysis may be open to criticism (R.

The relative radiosensitivity of the tumour in the OH compared to FFC nlice, virtually a measure of the effect of the changed genetic 5700 = 1-4 milieu, can be expressed as the ratio of the two LDzio S, 3950 4 (+ 0-05*). The magnitude of this ratio compared to its standard error shows the difference in radiosensitivity of the two groups to be highly significant (p < 0-0001).

Interestingly, although a lobulated appearance showed an increased risk, this did not reach statistical significance (OR, 3.45; 95% CI, 1.27–9.37; P < 0-001 0.015), suggesting that an increasingly irregular morphology is important in the risk of rupture.

Apart from South Asians, the highly significant association of this variant was also observed in Europeans (LOLIPOP, and UKBB) (0.19 ± 0.004; p = 2.36 × 10 − 420 ) and others (MEC_CHS, DC_SP2, SAMAFS, MISS_OLIVER) (0.09 ± 0.01; p = 1.15 × 10 − 11 ), adjusting for the effects of age, gender, BMI, diabetes, and PCs.

The difference is highly significant (X2 = 12X17, 1 df, P < 0-001).

The assay was performed on 39 normal donors who provided a mean value of 0'56?0 35 red cells/monocyte, whereas 32 patients with micrometastatic disease gave a mean of 0'92L0-51 red cells/monocyte, a difference which is highly significant (P<0-001) and indicates that monocytes from such patients show increased lytic- activity.

Normal mean = 0-32, CLL mean = 0 04, giving a highly significant difference between the two groups (t = 1 -I 1, degree of freedom = 59, P < 0-001). 0 N 116 n m n N-ACETYL NEURAMINIC ACID CONTENT OF HUMAN LYMPHOCYTES former method was used in all further preparations.

However, the average time of death of the 5/9 group I + C patients who died is 146 days post- relapse (because there were no late deaths) as against 291 for the 17/20 group I patients u'ho died. This second analysis could mislead the average reader into believing that there is highly significant (P < 0-01) evidence that chemotherapy worsens post-relapse survival.

Similarity of gene expression between the two groups was highly significant ( p = 1.0 e-323).

The difference between pathogenic and benign SVs was highly significant (rare versus common OR = 13.06, P = 5.43 × 10 - 323 , Fisher’s Exact Test).

For this comparison, we found a significant trend in the opposite direction ( p = 2.77 × 10 − 322 ) (Fig. 3 c).

4 C) and, although the overlap is small, it is highly significant compared with randomly reshuffled genomic regions ( P <10 −320 ; Fig. 4 C).

2d ) is highly significant for all possible overlaps between the stages (hypergeometric test, p < 1.921718e- 319 ) allowing for using of these differentially methylated CGs as peripheral markers of HCC.

Using (Log 2 [ β /(1 – β )]=0) as cutoff, Fisher’s exact test shows highly significant interdependence between gene expression and DNA methylation in the promoter region ( P = 4.5E-315) ( Figure 3 A).

Both conditions shared a highly significant overlap in their DEGs (396 overlapping up-regulated and 445 down-regulated DEGs; P < 10 −314 for both comparisons) and similarly regulated several direct YAP1 downstream target genes ( Supplemental Fig.

A χ 2 test ( supplementary table S1 , Supplementary Material online) revealed a highly significant overrepresentation of new–new and old–old node connections within the MMM12+ network, whether using OMA groups ( P < 1.1E – 311) (as is shown in fig. 1 B ) or MAP clusters ( P < 1.1E – 311).

This marker is a highly significant eQTL for MYOM2 on eQTLGen (P = 3.2717 × 10 –310 ) and GTEx (P = 9.5 × 10 –20 ) in whole blood.

All of the overlap between pairs of cohorts mentioned above was highly significant (Fisher’s exact p < 1×10 -308 ); however, a caveat of this analysis is that the four brain regions were sampled from the same set of individuals.

Considering all tested SNPs in open chromatin peaks (the majority of which presumably have no true effect on chromatin accessibility), the correlation is more modest, though highly significant (iPSC correlation 0.12; P < 10 −308 ).

Finally, introns and lincRNAs have a more tolerant gwRVIS score distribution that more closely resembles the distribution from intergenic regions, but due to the sheer size of the corresponding score lists the divergence remains highly significant (median scores: −0.050, −0.0015; Mann–Whitney U vs. intergenic: p < 1 × 10 −308 and p = 2.6 × 10 −168 , respectively).

The overlap between DroFN and the Drosophila proteome interaction map (DPiM [ 44 ]) was highly significant (Fisher Exact Test p < 10 −308 ).

Analysis of breast cancer transcriptomes (METABRIC cohort) also evidenced a very good correlation between the expression of FOLR2 and those of genes of the “anti-inflammatory gene set”, which reached statistical significance in most cases ( Figure 2 C), and was highly significant for CD163 (Pearson: 0.72; p = 1.71 × 10 −308 ) and even CD68 (Pearson: 0.59; p = 1.25 × 10 −176 ), another widely used marker for macrophage identification ( Figure 2 C).

We note that the P -value of the Spearman correlation was highly significant in every single case ( P -value <2e-308) because of the large number of data-points.

22A ) and revealed a highly significant correlation of effect sizes (Spearman’s rank correlation) between both types of variants ( r = 0.85, P < 2.2E−308).

These included four differentially methylated CpGs associated with eGFR; a highly significant cg21961721 within SLC27A3 ( p < 2.2 × 10 −308 ), two intergenic CpGs between ZNF788P and ZNF625-ZNF20 (cg17944885; p = 3.7 × 10 −13 and cg25544931; p = 2.1 × 10 −5 ), and cg05165263 within the IRF2 gene ( p = 6.6 × 10 −5 ).