Excerpts

While rs2555639 was the only SNP that was significantly associated with risk of colon cancer in each of the discovery and validation sets independently, several additional SNPs had highly significant association with risk when combining data from the discovery and validation samples ( Table 5 ), including rs1365611 (OR = 1.73, 95%CI:1.26–2.37, p = 0.0008), rs6844282 (OR = 1.42, 95%CI:1.10–1.83, p = 0.0078), and rs2332897 (OR = 1.74, 95%CI:1.27–2.38, p = 0.0006).

The association was strengthened by a positive Trend test for mild, moderate and severe asthma (Mild OR 1.0; Moderate OR 1.42. 95%CI 1.16, 1.74; Severe OR 2.01, 95%CI 1.64, 2.46; p = 0.0008).

The model was found to be highly significant ( p = 0.0008), with R 2 = 0.9524 and Adj-R 2 = 0.8913, indicating a good fit to the experimental data and good predictive capabilities.

We chose asthma nonetheless for its status as the most prevalent atopy in SIgAD patients (19.1%) [ 18 ], its highly significant GPS test statistic (p = 0.0008), and our access to a highly-powered asthma GWAS for use as an auxiliary data set ( Supplementary Table 1 ).

A highly significant difference was observed between the maximum stress value for the RC scaffolds versus XYP scaffolds when the deposition time was 45 min ( p = 0.0008, F = 81.55, and critical F = 7.71); however, no significant difference was observed for the elongation at break ( p = 0.24, F = 1.89, and critical F = 7.71).

Since the point values of the tests each deviate in a highly significant manner from normal distributions (Shapiro-Wilk tests: all p <0.0008), the data were subjected to a multivariate Box-Cox transformation [ 1 ].

A pooled analysis of all data showed a highly significant effect of colony environment on aggression (analysis of z-scores: whole model: F 18,982 = 2.43, P < 0.0008, foster colony aggression level: F 1 = 17.3, P < 0.0001, worker genotype: F 17 = 1.6, P < 0.069; the interaction term was non-significant and so excluded).

These proportions were highly significant by nonparametric test of trend (p=0.0008), but only the severe COVID-19 group reached statistical significance vs.

The NaOCl solution caused a highly significant reduction in post-operative discomfort ( p = 0.0010 day 3; p = 0.0007 day 7) and early painful failures ( p = 0.0008) compared with the control.

Mantel tests [ 27 ] of the significance of correlations between matrices of (i) pairwise population differentiation at the LWS locus, (ii) pairwise difference in water transparency, and (iii) pairwise geographical distance, revealed a highly significant positive correlation between LWS divergence and transparency (cross matrix correlation 0.80, p = 0.0008), but only a weak correlation between LWS divergence and geographical distance (0.55, p = 0.04), and an even weaker correlation between transparency and geographical distance (0.42, p = 0.08).

In our study, sVAS was confirmed to be an easy and quick tool to assess olfaction and to discriminate between normal and reduced sense of smell as demonstrated by a moderate correlation with all the S'S scores and a highly significant difference in the sVAS results between normosmics and dysosmics with a small effect size ( p = .0008; d = −0.34).

Remarkably, this revealed that, despite the relatively low r 2 for each individual chemokine, a highly significant ( p = 0.0008), four-chemokine model including CCL17 (TARC), CCL11 (Eotaxin), CCL2 (MCP-1), and PDGF-BB could explain about 80% of the variation in the proportion of HMC/CD34 in our cohort of SCD and healthy individuals ( Figure 4 B).

2 ), and in the group of vaccinated patients there was a significant trend for the size of axillary lymph node to decrease over time after vaccination ( r = −0.88 P < 0.0008, Fig. 3 ).

The difference between morphotypes was highly significant (t-test, T 10 = −4.78, P = 0.0008).

Nevertheless, ANOVA across the three biomarkers of neural cell development indicated highly significant differences among the three groups ( p < 0.0008) that depended both upon the specific measure and brain region (treatment × measure × region, p < 0.0002).

Its addition to a model with T and N stage was highly significant (p = 0.0008, likelihood ratio test).

The increased association of the Firre locus with the nucleolus surface in female versus male cells was highly significant ( P = 0.0008 by one-sample t-test).

In contrast to the analysis of the first event in the extended follow-up, the number of previous self-harm episodes was highly significant with an increased rate of recurrent self-harm in those with three or more self-harm episodes at baseline (HR 2·05, 95% CI: 1·35, 3·12, p-value=0·0008) and there was a higher rate of self-harm in those referred via hospital (HR 1·64, 95% CI 1·04, 2·61, p -value=0·0348). 3.6.

Analysis by annual percentage change (APC) identified four segments of interrupted trends for preterm live births, all with statistical significance: the 2000–2010 period showed an increasing trend (APC: 2.23; p = 0.0008); the 2010–2013 period demonstrated an accelerated growth (APC: 12.77; p = 0.0008); the 2013–2016 period showed a trend reversal with a decline (APC: −4.75; p = 0.0024); and the 2016–2023 period indicated a resumption of growth (APC: 1.78; p < 0.0001).

In the intermediate-risk group of the new Katagiri score, there was a clear trend toward choosing operative management as the SINS category indicated greater instability ( P = .0008) ( Supplemental Table 10 ).

When gender, VABS II and DBC were entered as covariates, we obtained a highly significant model of the SCQ score ( R 2 = 0.60, F = 8.8, p = 0.0008).

In the non-classical T lymphocyte subset, γδ T cells were increased in decidua compared to PBMC but did not reach statistical significance unless only third trimester animals were compared (two-tailed unpaired t-test, p-value = 0.0008) ( Figure 4A ).

Inter-annual variation in macroalgae cover was significant in five of the six study regions, and two of these displayed a significant trend over time with cover levels increasing in Baltic Proper inner (linear regression; P = 0.0008) and west coast inner (linear regression; P = 0.0182) (Online Resource 1).

The coefficient for PC1 is positive β ^ PC1 = 1.00 and highly significant ( p = .0008).

Pearson’s correlation revealed a highly significant association between age and transcript expression for both HDAC1 : F(1,316) = 11.46, r = −0.187, p = 8 × 10 –4 and HDAC2 : F(1, 305) = 62.17, r = −0.411, p < 10 –13 .