Excerpts

The two sample groups showed a highly significant difference regarding the intralesional abundance of T. pedis DNA (U = 146, p = 0.0009599).

For that 4-week period of spring 2020, the relative search volume for all 6 diseases was elevated above the pre-COVID baseline to a highly significant degree ( P <.00096 for all 24 values, corresponding to each of the 6 search terms through that 4-week period).

Statistically highly significant differences between conventional and organic farm isolates were detected for resistance to erythromycin (56/145 vs. 4/41; p = 0.000961) and clindamycin (81/145 vs. 6/41; p = 6.985 × 10 −6 ), as well as for tetracycline resistance in the alternative farm isolates ( p = 0.0001873) ( Figure 2 B and Table S3 ).

In addition, functional annotation of differentially expressed genes also showed a highly significant enrichment of genes involved in the development of the epidermis ( P = 9.63 × 10 -4 ), which also included downregulation of SPRR1A and B, KRT16 and KRT17 in old samples.

Heterozygous carriers of INHBE pLOF variants (1 in 587 individuals, combined frequency of 0.08%) had a favorable metabolic profile consisting of nominally significant associations with lower triglycerides ( P = 9.65 × 10 −4 , Beta = −0.13 SD), higher HDL cholesterol ( P = 0.01, Beta = 0.10 SD), decreased alanine aminotransferase ( P = 0.04, Beta = −0.08 SD) and lower fasting glucose ( P = 0.03, Beta = −0.17 SD).

GO analysis of the genes identified in REG4 and GATA6 knockdown cells revealed a highly significant enrichment for probe sets annotated as “cell cycle phase” ( P = 9.7 × 10 −4 ).

For the Ipi-N cohort, this increase in TCR.strong score was highly significant (p = 0.00097) in those with evidence of clinical benefit, which was not captured by the T cell activation metric ( Figure 7 D).

Notably, LIHC and TGCT alone each show marginally significant correlation between the G>T/C>A mismatch ratio and pass variant call ratio by reference strand (Pearson correlation = 0.295 and 0.212, P = 9.75e-4 and 4.46e-2, respectively).

Genetically determined serum 25-OHD levels were associated with an increasing trend in FN-BMD (beta = 0.126; 95%CI: 0.0512,0.201; P = 0.000976) (S21 Table of S1 File ), but not in TB-BMD, LS-BMD, or FA-BMD (S21 Table of S1 File ).

These data amounted to a statistically highly significant association between prior autoimmune autoAb positivity and subsequent development of anti-IFN-I autoAbs (P = 0.0009766; Fig. 4 E ).

Rs4905014 has an age-dependent effect on stroke Nominally significant association of rs4905014 was observed with HC ( p = 9.78e-04) and stroke ( p = 3.75e-21) in ARIC, and with DBP ( p = 2.55e-02), HbA1c ( p = 1.44e-02), and HF ( p = 2.58e-02) in MESA (Table 3 ).

Across 15 mutation categories (see Additional file 1 ), there was a highly significant trend for users to have fewer mutations (SNVs and indels) than non-users (sign test p < 9.8 × 10 −04 ; Additional file 2 : Tables S5 and S7).

Its best alignment to the predicted site had eight strong matches (Figure 3G ), which is likely to be significant ( P = 0.00098).

The association for rs6445055 remained nominally significant, albeit reduced (p= 9.87×10 −04 , β= −0.121 compared to −0.177 prior to adjustment for CCT).

Lastly, statistical analysis revealed a highly significant (MonteCarlo, P =0.00099) correlation between DEGs of normal ageing versus bcat-1 RNAi, suggesting a global functional relevance of BCAT-1 for the process of physiological ageing.

Across the life span of WT flies, we noted a clear trend of increasing DLM firing rates, which nearly doubled in the oldest flies examined [ Fig. 1 D , E ; Spearman rank correlation coefficient ( r s ) = 0.46, p = 9.9 × 10 −4 , and r s = 0.58, p = 3.6 × 10 −4 , respectively, for 25°C-reared and 29°C-reared flies].

Since highly significant ( P = 0.000996) overactivation of NFKB1 was observed in SOD1 astrocytes, we further investigated NFKB isoforms by qICC.

For schizophrenia, the statistical analysis revealed that 25 out of the top 30 gene pairs shared at least one Biological Process (BP) pathway, and the observed enrichment is highly significant ( P = 9.99 × 10 –4 , computed as ( w + 1)/(1,000 + 1) where no background iterations reached ≥ 25, thus w = 0) compared to random expectations.

Finally, since in this experiment there was no significant effect of body mass, it is questionable whether it is actually necessary to include body mass into the ANCOVA model, and if removed the ABX treatment effect becomes highly significant (F 1,24 = 18.6, P < .001).

These revealed highly significant effects of treatment on C org density for each of the species: F (1, 180) = 38.68, p < 0.001 for T . hemprichii ; F (1, 180) = 27.89, p < 0.001 for T . ciliatum ; F (1, 180) = 32.16; p < 0.001 for E . acoroides and F (1, 180) = 11.55, p = 0.003 for S . isoetifolium .

Results In the three years prior to the experiment (2008–2010), mean DNA yields from samples taken from the field for bare fallow, arable and grassland were 21, 95 and 298 μg g -1 dry soil, respectively with no significant differences between replicate plots within each treatment and highly significant differences between treatments ( F 2,18 = 646, P < 0.001, all means significantly different at α = 0.05) and no interaction between treatments and years, indicating that the effects of treatments and time were independent.

The adduct levels in the RADPLAT 100 schedule were statistically significantly higher than those after the CERVIX 40 schedule for both tumors (Student t -test, P = 0.01) and normal tissues (Student t -test, P < 0.01). A highly significant linear correlation (Pearson correlation, r = 0.93, P <0.001, n = 61) was observed between the level of GG and AG adducts in WBC (see Fig. 1 a), with a mean ratio of GG/AG adducts of 7.6 ± 2.1 SD.

Apart from deviating from a standard neutral model, some loci pairs (1813, 1955) had positive LD (D′) results with highly significant ( p < 0.001) χ 2 values of 19.7 and 12.7 among Homa Bay and Kisumu sequences, respectively ( Supplementary Table S1 ).

Statistical analysis revealed a highly significant difference ( P < 0.001 ) between these two patient polulations (Fig. 2 A).

Genetic differentiation between all population comparisons was highly significant ( P < 0.001).