All CA mutants showed impaired transduction efficiencies in CD4 + T cells, in which CypA is an LV promoting factor, despite similar infectivity as the wild-type (WT) vector in 293T cells ( Supplementary Table S1 ) ( Figure 6a , white bars, mutants versus WT, P < 0.0001 for all except A92E which did not reach statistical significance).
While the improvement within the SOD group was highly significant (p < 0.0001), the between-group difference (~11%) did not reach statistical significance (p = 0.089), possibly due to limited power and smaller-than-anticipated effect size [ 7 ].
The use of mifepristone showed a reduction in the use of oxytocin (RR = 0.84; 95% CI: 0.70–1.01), although this difference did not reach statistical significance ( p = 0.065), and a highly significant reduction in prostaglandin use (42.7% vs. 78.9%; RR = 0.54; 95% CI: 0.48–0.60; p < 0.0001), with no significant difference in cesarean section rate (18.9% vs. 23.6%; RR = 0.80; 95% CI: 0.63–1.01; p = 0.068).
Lower PlGF MoM and higher MAP MoM were also found in LO-PE pregnancies, however the difference in PlGF MoM did not reach statistical significance (MAP –1.05 MoM, p<0.0001; PlGF –0.90, p = 0.024).
Although DOX-treated animals exhibited a downward trend in body weight over time, vitamin D-treated groups showed a partial attenuation of this pattern; however, these differences did not reach statistical significance ( Figure 1 ). 3.2. 99 mTc-PYP Uptake in Liver Hepatic 99 mTc-PYP uptake differed significantly among the experimental groups (F(5,36) = 57.97, p < 0.0001, R 2 = 0.8895).
In the subgroup with low or intermediate risk of recurrence the differences in the recurrence-free survival did not reach statistical significance (p = 0.36), however, in high-risk cases there were highly significant differences among the surgical groups (p <0.0001, Figure 2 ).
After 12 months, uMCP1 excretion was lower in the tolvaptan than in the placebo group, but did not reach statistical significance until 24 (13.8 ± 3.4%, P<0.0001) and 36 months (14.4 ± 3.7%, P<0.0001).
The observed increases in coronary pressure gradient, stenosis resistance, and flow velocity did not reach statistical significance; however, the diastolic velocity–pressure gradient relation was consistent with a significant increase in relative stenosis severity (k coefficient, P <0.0001), in keeping with exercise-induced vasoconstriction of stenosed epicardial segments and dilatation of normal segments, with trends toward reversal with nitroglycerin.
In our study, internal adenomyosis was more frequent but did not reach statistical significance, with a disrupted and ill-defined junction zone, characteristic especially of internal adenomyosis ( p = 0.0001).
The difference between men and women in the proportions of cavus (men 31.6%, women 29.0%) and planus (men 29.0%, women 24.3%) foot posture did not reach statistical significance, yet the difference in proportions of foot function did ( P < 0.0001).
While differences in individual proteins did not reach statistical significance, overall, a greater number of proteins were elevated in the higher diversity group relative to the lower diversity group (Fisher’s exact test, P < 0.0001).
Meta‐Analysis of Butyric Acid Concentration in Patients With Periodontitis Meta‐analysis indicated an overall decreasing trend in butyrate levels in GCF or saliva from patients with periodontitis; however, the difference did not reach statistical significance (SMD = −1.58, 95% CI: −6.53 to 3.36) and heterogeneity was substantial ( I 2 = 90.9%, p < 0.0001; Figure 3 A).
The association of duration of use remained highly significant for moderate or greater AR ( p < 0.0001) but the association with moderate or greater MR did not reach statistical significance ( p = 0.09, one-sided) while the trend for moderate or greater TR remained statistically significant ( p = 0.007, one-sided).
At wave 2, all three scales were positively correlated; however, the correlation between neighborhood social ties and neighborhood safety was low in magnitude (0.031) and did not reach statistical significance (both other correlations were significant at the p < .0001 level).
With the HEMI groups, although LIB appeared to induce a slight decrease in reversal learning during both dark phases, these differences did not reach statistical significance upon comparing between the HEMI Sham and Blast groups [Time: F (4.687, 103.2) = 39.35, p < 0.0001; Group: F (1, 30) = 0.2318, p = 0.6337; Time × Group: F (46, 1,380) = 0.4483, p = 0.9995; Subject: F (30,1,380) = 26.52, p < 0.0001]. 3.2 Cognitive flexibility of the reversal learning The main purpose of the reversal learning phase is to evaluate cognitive learning flexibility of the HEMI and NCAR mice.
Weak negative and positive trends were observed between “Junk food” (rho = −0.19, p = 0.003) ( Figure 4 D) and “Beans” (rho = 0.17, p = 0.008) ( Figure 4 E), respectively, and EPA levels, although their p values did not reach statistical significance using the cutoff point of p = 0.00016.
It is not unexpected that race did not reach statistical significance in the stratified analysis, even though it was a strong predictor in the non-stratified model ( Table 1A , p = 0.0002).
MR associations between genetically proxied GP6 and overall stroke risk and ischemic stroke risk showed the same direction as cardioembolic stroke but did not reach statistical significance after multiple testing correction (OR wald ratio , 1.63 [95% CI, 1.25–2.13]; P =3.7×10 −4 ; FDR=0.22; Figure 2 ; Table S3 ).
These findings reflect acute acid–base disturbances triggered by the rapid volume shift, even though the overall group comparisons did not reach statistical significance. Due to hemodilution, the blood lactate concentration in the ANH group increased markedly at the T 1 time point ( p < 0.0004), likely due to hypoperfusion-induced anaerobic metabolism, and remained elevated at the T 2 time point compared to the control ( p = 0.0018) and sham ( p = 0.0157) groups ( Figure 2 D).
GFP lo cells appeared reduced in gata2a um27/+ embryos at 56 hpf, however, this did not reach statistical significance when compared to WT ( Figure 2H ), nonetheless, Pearson’s correlation again suggested a contributing effect across genotypes (Pearson r = − 0.55, p = 0.0004).
While the moderator analysis did not reach statistical significance, subgroup analysis showed a significant difference in occlusion rates between FD and coiling (χ 2 = 12.59, p = 0.0004).
were elevated in participants receiving SCF compared to placebo, but this did not reach statistical significance after correcting for multiple comparisons ( p = 0.0004, FDR q = 0.073, ANCOMBC).
IL-6 Receptor sIL6R showed a suggestive modest negative effect on COVID-19 outcomes (ORs ranging 0.94 to 0.97) ( Figure 4 ), but these did not reach statistical significance, except for COVID-19 infection, i.e., HGI_ALL_C2 ( p = 0.0005). 3.3.
Although the CGGGG indel did not reach statistical significance independently in all three cohorts, the combined analysis revealed a clear association signal between the CGGGG indel and MS (p = 0.0005), with the longer allele (4×CGGGG) as the risk allele.
MaAsLin2 analysis revealed a higher relative abundance of Eggerthella in the cranberry group at week 6, although this association did not reach statistical significance after multiple testing correction ( p = 0.00052, q = 0.0976).