“did not reach statistical significance”

Interestingly, although a lobulated appearance showed an increased risk, this did not reach statistical significance (OR, 3.45; 95% CI, 1.27–9.37; P < 0-001 0.015), suggesting that an increasingly irregular morphology is important in the risk of rupture.

Using the aggregated network, we observed that the number of first-degree protein partners was higher in selected MR gene-traits as compared with gene-traits that did not reach statistical significance ( p < 2e−16).

Both fast and slow timescales of cross-correlations increased with the RF-center distance in both monkeys, but the increase in the fast timescale did not reach statistical significance in monkey N ( τ 2 : p < 10 −10 , τ 1 : p G < 10 −10 , p N = 0.36, two-sided Wilcoxon rank-sum test), possibly due to narrower range of RF-center distances in monkey N compared to monkey G (median d RF,N = 0.77, d RF,G = 2.08 dva).

Although the majority of the findings in these included studies did not reach statistical significance, the overall efficacy assessment indicated that SLIT demonstrated effectiveness in pediatric AR patients (SS: SMD=-0.52, 95%CI=-0.75~-0.29, p = 3.17e-10, I2=0%, Egger’s test: p = 0.74; MS: SMD=-0.24, 95%CI=-0.37~-0.11, p = 0.0356, I2=78.68%, Egger’s test: p = 0.34) ( Figure 6 ).

Although these variants did not reach statistical significance individually, the results were highly significant when they were combined (OR = 3.72; 95% CI = 2.38–5.82; p = 8.9 × 10 –10 ) ( Vallet et al., 2015 ). 22 distinct variants were recently identified in a Belgian population.

Individually, these did not reach statistical significance, but when information was combined for all rare variants with an allele frequency of <1%, the results were highly significant (OR = 3.72; 95% CI = 2.38–5.82; P = 8.9 × 10 −10 ).

The risk allele G of rs7535263 was also more frequent in cases (allele frequency, 64 of 104 [62%]) of cohort 2 compared with controls (allele frequency, 1451 of 2584 [56%]) but did not reach statistical significance, most likely representing an underpowered comparison (combined meta-analysis (OR, 0.58; 95% CI, 0.38-0.77; P = 3.0 × 10 −8 ) ( Figure 4 ).

A ) Cis -eQTL SNPs were located nearer H3K4me3 peaks in CD4 T EM cells than the 159 top SNPs that did not reach statistical significance at 5% FDR ( p = 1.10×10 −7 , one-sided Mann-Whitney test).

The association of the lead variant rs1818163 showed a similar direction of effect but did not reach statistical significance (β=0.0558, se =0.0106, p=1.39×10 −7 ).

12 Although RBM20 mRNA levels tended to be higher in both DCM and ICM samples compared to controls ( Figure 3 E ), the increase did not reach statistical significance in DCM ( P = 5.73 × 10 −7 ; Log 2 FC = 0.92).

Specifically, phase 1 showed P =8.5×10 – 7 with a small-to-moderate effect size (η 2 =0.0591), and statistically significant differences were found among all groups except between the EG-OFF and EG-ON; phase 2 showed P =.0028 with a small effect size (η 2 =0.0239), and no statistically significant differences were observed between the CG and the EG-ON; phase 3 showed P =.0081 with a small effect size (η 2 =0.0419), and the comparison between the CG and the EG-ON did not reach statistical significance; and phase 4 showed P =7×10 – 7 with a moderate effect size (η 2 =0.0650), and statistically significant differences were observed among all groups.

Although, individually, 5 studies data did not reach statistical significance [ 63 , 80 , 87 , 88 , 99 ], the overall effect showed the reduction of CRP levels after supplementation (MD: −1.10, 95% CI: −1.26, −0.93, p < 0.00001, Figure 13 ).

However, after correction for multiple testing, the association did not reach statistical significance (an interaction term P -value <0.00001 was considered statistically significant after correction for the number of interactions tested [23×23 = 529; 0.05/529 = 9.5 10 −5 ].

However, the effect estimates from the four studies reporting HRs did not reach statistical significance (HR: 1.12, 95% CI: 0.96–1.31; I 2 = 100%, p < 0.00001) ( Figure 2 ).

The top result did not reach statistical significance (Bonferroni threshold for number of genes, p-value < 1.93 × 10 −5 ) was with increased predicted expression of ETS variant 4 ( ETV4 ; chromosome 17; p-value = 0.0015).

In agreement, t tests between viruses exhibiting high or low transmission and titers from NW specimens generally did not reach statistical significance in RDT experiments, but did in DCT experiments, notably for mean peak NW titer (RS-p = 2.05e-5, with mean titers of 5.76 and 6.93 log 10 EID 50 /ml for viruses exhibiting ≤50% or >50% transmissibility in a DCT setting, respectively) (Fig. 2A–C , Supplementary Table 2 ).

hsCRP For hsCRP, strong association signals were detected in the previously described CRP gene (rs1205, p = 8.20×10 −30 ) and in the 3′ of APOC-I ( Apolipoprotein C-I ) gene (rs4420638, p = 7.12×10 −11 ) ( Figure 3C and 3D and Table 2 ), a well known determinant of serum hsCRP that did not reach statistical significance (p = 2.85×10 −5 ) in our initial scan (Stage 1) [25] .

All pairwise comparisons between groups did not reach statistical significance except for the comparison of PR interval by age group (ANOVA P = 5.6E-05).

Sensitivity analyses’ results In addition to the IVW method, the WM method also showed a marginally positive significant association between total lipids in S.HDL.L and UC (OR = 1.201, 95% CI: 0.994–1.451, P = 0.052) [ Table 2 ], although this association did not reach statistical significance at a Bonferroni-corrected threshold ( P < 9.94 × 10 −5 ).

The association of duration of use remained highly significant for moderate or greater AR ( p < 0.0001) but the association with moderate or greater MR did not reach statistical significance ( p = 0.09, one-sided) while the trend for moderate or greater TR remained statistically significant ( p = 0.007, one-sided).

Indeed, patients with a high LSC17 score were less likely to achieve MRD-negative remission regardless of the treatment regimen received, although this did not reach statistical significance in the smaller group of patients treated with FLAG-Ida ( Online Supplementary Table S5 ; 30/52 [58%] vs . 54/59 [92%]; P <0.0001 for 7+3; 8/18 [44%] vs . 9/11 [82%]; P =0.06 for FLAG-Ida).

Although the changes between individual phases (T1 through T5) did not reach statistical significance, the main effect of experimental phase was highly significant ( p < 0.0001).

While differences in individual proteins did not reach statistical significance, overall, a greater number of proteins were elevated in the higher diversity group relative to the lower diversity group (Fisher’s exact test, P < 0.0001).

While the improvement within the SOD group was highly significant (p < 0.0001), the between-group difference (~11%) did not reach statistical significance (p = 0.089), possibly due to limited power and smaller-than-anticipated effect size [ 7 ].

In our study, internal adenomyosis was more frequent but did not reach statistical significance, with a disrupted and ill-defined junction zone, characteristic especially of internal adenomyosis ( p = 0.0001).