Barely Significant
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“did not reach statistical significance”

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The subgroup analysis of Osteoarthritis demonstrated a significant worsening of the opioid therapy compared to placebo ( p = .048), while the Low Back Pain subgroup showed a trend towards an advantage in the opioid group, although it did not reach statistical significance ( p = .052).
While the presence of joint effusion, synovial hypertrophy and PD signal in a joint was associated with arthritis development in that joint [odds ratio (OR) 3.07 (95% confidence interval (CI) 1.05–8.94), OR 5.45 (95% CI 2.32–12.8), and OR 5.50 (95% CI 2.57–11.9), respectively] only a positive trend between these US findings and the development of IA was observed at patient level, and this did not reach statistical significance [OR 2.05 (95% CI 0.80–5.27), OR 1.41 (95% CI 0.54–3.65), OR 1.54 (95% CI 0.67–3.54), respectively].
We found that (1) Chinese-English bilinguals showed a significant priming effect for congruent binomials but no facilitation for English-only binomials, (2) English–Chinese bilinguals showed a trend toward priming for congruent binomials, which did not reach statistical significance, and no priming for English-only binomials, (3) English monolinguals showed comparable priming for congruent and English-only binomials.
did not reach statistical significancep = 0.0581.2× alphaplainly factual
As Figure 3 B shows, with regard to the cognitive domain, both groups evolved in parallel; however, unlike the placebo group, the melatonin plus zinc group showed a trend towards improvement that was maintained over the 16 weeks of treatment, although it did not reach statistical significance (16 weeks vs. baseline, p = 0.058).
did not reach statistical significanceP = 0.0811.6× alphaplainly factual
In the analyses including the extreme values ( Table S2 in Additional file), the significant increase in CSF NfL in the low burden group in definition 1 was lost ( P = 0.051). In definition 2, CSF neurogranin and NfL also showed a trend to increased values in the low burden group, but did not reach statistical significance ( P = 0.081 and P = 0.080 for CSF neurogranin and NfL, respectively) (Table 3 , Fig. 1 ).
Effect of Hypobaric Perfusion on Prevention of Congestion, Edema, and IR Injury Following Ex Vivo Whole-blood Perfusion Ex vivo perfusion with autologous porcine blood after 3 h of static cold storage showed a trend toward a decreased maximal arterial pressure and increased maximal blood flow in the hypobaric perfusion group, although this difference did not reach statistical significance (Figure 3 A and B).