“did not reach statistical significance”

Similarly, changes in the PaO2/FiO2 ratio showed a trend toward positive correlation with the cardiac output ( r = 0.48, p = 0.166) and negative correlation with the RVEDD/LVEDD ratio ( r =-0.46, p = 0.118), but these did not reach statistical significance (eTable 4 ).

While Group B1 showed a trend toward improved skill assessment scores, this difference did not reach statistical significance ( p = 0.167).

Although both OS and RFS showed a trend favoring the laparoscopic group, these differences did not reach statistical significance (OS: P = 0.174; HR, 0.78; 95% CI, 0.55–1.11; RFS: P = 0.166; HR, 0.78; 95% CI, 0.56–1.11). 65.3% of patients in the LG group and 71.1% of patients in the OG group experienced recurrence ( P = 0.472) (Table 3 and Supplementary Table S5).

Marginal tests identified Lineage (N versus S) as the primary driver of variation ( p = 0.016), while Region ( p = 0.046) showed a borderline significant effect, and Host ( p = 0.178) did not reach statistical significance.

Group B showed a trend towards improvement at 3 months (+1.67 ± 1.16%, P = 0.178) and at 6 months (+2.07 ± 1.21%, P = 0.115), although these changes did not reach statistical significance.

Although a slight trend in PT was observed among the rs6046 genotypes ( p = 0.179; Figure 1 B), this effect did not reach statistical significance.

Histologic subtype showed a nonsignificant trend toward worse outcomes (HR = 1.55, 95% CI = 0.81-2.96, p = 0.18), and high PD-L1 expression (CPS ≥10) exhibited a similar trend toward poorer survival (HR = 1.68, 95% CI = 0.90-3.14, p = 0.09), although these did not reach statistical significance after adjustment, likely attributed to the limited number of PR cases and small cohort size (Table 2 ). 3.3.

Although PD-L1 CPS ≥5% showed a positive trend toward response, the association did not reach statistical significance (adjusted OR: 1.4; p = 0.18).

While poorly differentiated tumors showed a trend toward poorer survival (HR 2.00, 95% CI 0.73–5.03, p = 0.187), this association did not reach statistical significance.

Although a numerical trend toward a higher proportion of PR3-ANCA positive cases was observed during the pandemic period, this difference did not reach statistical significance ( p = 0.190).

Although the proportion of COX2‐positive cells among PDGFRα‐positive cells showed a trend toward increase after BDL, this did not reach statistical significance ( p = 0.1905) (Figure 6b ).

For OS, although rMDS-predicted responders showed a trend toward improved outcomes (log-rank test, P = 0.197), this did not reach statistical significance.

Although PAFR expression did not reach statistical significance in either model, it showed a clear trend toward association with both MASLD (OR = 9.85, p = 0.197) and MASH (OR = 2.83, p = 0.068), supporting its potential role in disease progression (Table 2 ). 3.3 Hepatic Relative mRNA Expression of PAFR in Relation to Histological Features To further investigate the relationship between hepatic PAFR expression and histological characteristics of MASLD, we analyzed its expression across different grades of steatosis, lobular inflammation, hepatocellular ballooning, and NAS (Figure 3A ).

Although the reduction in anxiety in the hypnotic group did not reach statistical significance, it exhibited a favorable trend ( β = –0.58, 95% CI: –1.39 to –0.22, P = 0.20).

Latency to onset in rats that became diabetic was similar in the three groups, and for this reason, the Kaplan Meyer plot ( Figure 4A ) of the three groups showed a trend that did not reach statistical significance (p<0.2).

Conversely, although a negative trend was observed for PM 2.5 × CO 2 in the DS proportion model ( p = 0.20), this did not reach statistical significance.

The primary clinical endpoint of death or mechanical ventilation from day 6 to 29 in patients with high viral load had a positive trend towards a reduction in treated patients, that did not reach statistical significance [relative risk reduction (RRR) 25.5%; 95% CI –16.2, 52.2; p = 0.20].

While a higher IFNα response score showed a favorable trend toward improved EFS, this association did not reach statistical significance (HR=0.79, 95% CI 0.54 to 1.14, p=0.20; online supplemental figure S6G ).

Responses to noxious or innocuous mechanical stimulation showed a trend toward reduced sensitivity that did not reach statistical significance (pin-prick response score: 89% ± 3% versus 83% ± 3%, for control versus hM3Dq mice, p = 0.21 unpaired t test; von Frey test threshold: 3.9 ± 0.2 g versus 4.2 ± 0.2 g, p = 0.22; brush test response score: 91% ± 3% versus 81% ± 5%, p = 0.13).

When stratified by sex, this association remained statistically significant only among women (r2 = 0.126, p < 0.05) (Figure 1B ), whereas in men the relationship did not reach statistical significance despite a positive trend (r2 = 0.07, p = 0.21) (Figure 1C ).

Arterioles in the skin also showed a trend towards differences in occlusion ratios, yet these results did not reach statistical significance ( p = 0.21 and 0.12) ( Fig 4 ).

The results revealed a marginal trend for training weeks (β = −0.074, SE = 0.059, z = −1.251, p = 0.211, 95% CI: −0.190, 0.042), suggesting a slight decreasing trend in intervention effects with increasing training duration, though this did not reach statistical significance.

The anti-inflammatory properties of asiatic acid were demonstrated through significant reductions in key pro-inflammatory cytokines, including tumor necrosis factor-α (32.036 versus 55.182 in controls, p = 0.026) and interleukin-1β (86.685 versus 123.02 in controls, p = 0.016), while interleukin-6 levels showed a trend toward reduction that did not reach statistical significance (155.0 versus 215.5, p = 0.219) [ 237 ].

Zone 2 placement showed a trend toward lower mortality than Zone 1 (aOR, 0.28; 95% CI, 0.03–2.19; P = 0.22), but this did not reach statistical significance.

Although the MetS group showed a trend toward a slower longitudinal increase in CAVI compared with the non-MetS group, this interaction did not reach statistical significance (β = −0.089, p = 0.220).