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showed a trendP = 0.0571.1× alpha
Somatic variants showed a trend for being more damaging as reflected by the phred-scaled combined annotation-dependent depletion (CADD) score ( P = 0.057; Fig. 4B ) and for being located at more conserved positions as indicated by the genomic evolutionary rate profiling (GERP) score ( P = 0.062; Fig. 4C ).
showed a trendp = 0.0571.1× alpha
Clinical results At day two following treatment, ketamine significantly improved MADRS scores (mean difference -6.5 [95% CI -10.6 to -2.5]; paired t -test, p = 0.003), TEPS-anticipatory scores (mean difference 6.8 [95% CI 2.9 to 9.5]; paired t -test, p = 0.038), TEPS-consummatory scores (mean difference 5.6 [95% CI 1.8 to 6.1]; paired t -test, p = 0.018) and showed a trend to improve SHAPS scores (mean difference -5.2 [95% CI -10.7 to 0.2]; paired t -test, p = 0.057) compared to placebo (Supplementary Fig.
showed a trendp = 0.0571.1× alpha
Compared to the control group, SMT participants improved their fall risk score ( p = 0.036), proprioception ( p = 0.015), reaction time ( p = 0.003), sit-to-stand performance ( p = 0.011) and executive functioning ( p = 0.001), while KIN participants improved their muscle strength ( p = 0.032) and vision ( p = 0.010), and showed a trend towards improved fall risk scores ( p = 0.057).
showed a trendp = 0.0571.1× alpha
GABA-currents recorded in KO UNT-oocytes showed a trend towards a decrease with respect to WT UNT-injected oocytes ( Fig. 6f , WT UNT, 100 ± 3.51%, n = 90; KO UNT, 87.21 ± 5.93%, n = 77, p = 0.057), while EC 50 and n H ( Fig. 6g ) remained similar (WT UNT, EC 50 = 93.74 ± 5.21 μM, n H = 1.16 ± 0.05, n = 13; KO UNT, EC 50 = 97.8 ± 4.30 μM, n H = 1.24 ± 0.06, n = 18).
showed a trendp = 0.0571.1× alpha
The subsequent RM-ANOVA analysis performed to evaluate the metabolic programming effects of CCX within the diet groups, showed a trend towards an interaction between time and metabolic programming effect ( p = 0.057, RM-ANOVA) and towards a metabolic programming effect ( p = 0.089, RM-ANOVA) only in CAF-fed animals ( Figure 3 A).