“showed a trend”

Divergence emerged over time: at 4 and 5 months the tUS– group showed a trend toward lower DI values compared to tUS+ (p = 0.044 and p = 0.017 uncorrected; Bonferroni-adjusted p = 0.265 and p = 0.101, respectively).

Gender showed a trend toward better OS for females, reaching significance for PnI patients (HR 0.75, p = 0.045), but not for LVI individuals (HR 0.80, p = 0.12).

This analysis revealed that learning-related changes in MT showed a trend toward significant correlation with changes in beta ERD in P-SMC ( β = 0.036, p = 0.045; with all conditions included, β = 0.030, p = 0.089; Fig.

In contrast, patients with a dilated left atrium (LAVi ≥ 40 mL/m 2 ) showed a trend toward worse outcomes with propafenone, including higher 1-month mortality (HR 3.6, p = 0.045) and slower cardioversion (median 18 h vs. 6.4 h with amiodarone, p = 0.05) ( 56 ).

And the 12-month DoR rate in OG and CG was 50.0% (95% CI: 27.1–69.2%) and 22.2% (95% CI: 3.4–51.3%), which showed a trend toward marginal statistical significance ( χ 2 =4.034, P =0.045).

Analyses on specific metabolizer phenotypes showed a trend for higher frequency of CYP2D6 ultrarapid metabolizers (UMs) in remitters compared with non-remitters in patients with TRD (χ 2 = 4.76, p = 0.045), but not in patients without TRD (χ 2 = 0.02, p = 1.00, Supplementary Table S9 ).

Further analysis showed a trend towards a higher utilization of non-excisional techniques in males ( p = 0.045) and a significant association between co-morbidities and the use of excisional techniques ( p = 0.049) (Table 1 ).

Among females aged 16–18 years, infection was more frequently associated with attending college and rural schools, and showed a trend towards increasing prevalence with increasing social deprivation ( P =0.045).

However, we did not observe a significant prognostic impact of HR FISH as defined by the R2‐ISS classification in NDMM patients, and in RRMM, HR FISH showed a trend toward shorter PFS (median: 6.5 vs. 11.6 months, p = 0.045) and OS (median: 19.7 months vs. not reached, p = 0.11) (Supporting Information S1: Figure S2 ).

In addition, exploratory biomarker analyses, including the assessment of EGFR gene copy number by FISH, EGFR and p-AKT protein expression by IHC, EGFR, K-RAS and D-RAF mutational status, showed a trend towards a better survival outcome for gefitinib in patients with high EGFR-gene-copy number (HR 0.61 for high copy number and HR 1.16 for low copy number, P = .045), while patients with EGFR mutations obtained higher RR than wild-type patients (37.5% versus 2.6%) [ 31 ].

Notably, COL9A2 , a chondrogenic cough-associated gene, showed a trend toward downregulation across both comparisons (log 2 FC = −0.65, P = 0.0456; log 2 FC = −0.69, P = 0.0175), suggesting a potential role in structural changes to the extracellular matrix contributing to chronic cough through altered airway mechanics or fibrosis.

Conversely, at a dosage of 21 (range, 20–22) mg/kg/day, the posaconazole concentration showed a trend toward significantly lower concentrations compared to the dosage of 18 (range, 17–19) mg/kg/day (P=0.046, Table 2 ).

However, although HbA1c showed a trend toward significance ( P = 0.046), but did not meet the Bonferroni-adjusted threshold ( P > 0.025).

Upper limb tremor severity showed a trend toward higher action tremor in ET-ns ( p = 0.046, rank-biserial correlation = 0.428), but this difference did not survive correction for multiple comparisons ( p_adj (FDR) = 0.098).

Attachment avoidance (AVD) did not significantly modulate theta during Reappraise (ps ≥ 0.19), but showed a trend toward increased theta during Suppress in the mPFC bilaterally (L mPFC: β = 0.139, SE = 0.069, t = 2.00, p = 0.046; R mPFC: β = 0.140, SE = 0.069, t = 2.01, p = 0.045).

(1989) [ 11 ] state that the incidence of serious bacterial infections showed a trend to be associated with an IgG level < 6.4 g/L (p = 0.046).

Patients treated with cangrelor showed a trend toward higher odds of achieving a discharge with a mRS 0 to 2 (40% versus 26.7%; OR, 2.42 [95% CI, 1–5.78]; P =0.046).

The association between GCTTC haplotype non-carriers and advanced tumor size showed a trend towards significance (OR = 0.380, 95% CI: 0.166–0.869, p = 0.046).

2 . Discussion In our study, the high-dose group (0.5–0.9 μg/kg/h) showed a trend of relatively weaker neuroprotective effect compared to the low-dose group (0.1–0.5 μg/kg/h) on postoperative Day 2 ( p = 0.046).

SASH1 expression showed a trend toward association with prognosis ( P = 0.0463), with the low-expression group exhibiting lower survival probability, suggesting SASH1 as a potential favorable prognostic marker, though further validation is needed.

47.8%, p = 0.005) and showed a trend towards lower valproic acid use (21.7% vs. 29.6%, p = 0.047), but more likely to receive antidepressants (53.8% vs. 39.5%, p < 0.001), benzodiazepines (39.9% vs. 26.6%, p < 0.001), and gabapentinoids (8.5% vs. 4.5%, p < 0.001).

Furthermore, glutamic acid (Glu, p = 0.059), glucose 1/6-phosphate (G1P/G6P, p < 0.100), and citric acid ( p = 0.091) showed a trend of higher levels in the DYS group than in the None group, while succinic acid was at a lower level ( p = 0.047) ( Table 3 ).

Additionally, despite BMS patients with clinically significant OC symptoms showed a trend toward worse outcomes in sleep quality, as indicated by higher PSQI scores (median 9 [7.5–10] vs. 8 [ 6 – 10 ], p = 0.047) compared with BMS patients without clinically relevant OC symptoms; this difference was not statistically significant.

Trunk flexor and extensor strength was lower in LBP patients, with a reduced trunk flexor/trunk extensor ratio (0.77±0.20 vs 0.96±0.16, P <0.001); hip flexor/extensor ratios showed a trend toward imbalance (left hip flexor/hip extensor: 0.60±0.15 vs 0.67±0.12, P =0.047).

In this analysis the LIBERTY and SCIENCE groups showed a trend towards reduced Anti-mask Belief that did not survive multiple comparisons correction (LIBERTY: t(587) = − 2.475, p = 0.047, SCIENCE: t(587) = − 2.537, p = 0.04).