Barely Significant
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“showed a trend”

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In the literature

100 Additionally, a retrospective study from Rome of 1640 patients (32.7% women) showed a trend toward more major adverse limb and cardiovascular/cerebrovascular events in men, though the differences were not statistically significant. 101 Conversely, another study reported no differences between the sexes in mortality in CLI patients. 102 A comprehensive meta‐analysis of 40 studies,
Dupilumab attenuates TSLP and IL-8 expression induced by co-stimulation with dsRNA and IL-4 Dupilumab pretreatment (10–1000 ng/mL) showed a trend toward reducing TSLP gene expression induced by co-stimulation with IL-4 and dsRNA (relative TSLP expression: IL-4 + dsRNA group, 1.893 ± 478.1; dupilumab 10, 100, and 1000 ng/mL groups, 1.779 ± 313.2, 1.700 ± 225.8, and 1.669 ± 568.7, respectively).
A post-hoc analysis on 23 prospectively treated C1-2 joint fusion patients, all of whom were first treated with an intra-articular lateral C1-2 joint local anesthetic and steroid injection, showed a trend toward higher surgical success in patients who had success with the injection, but the response was not statistically significant, possibly due to the small numbers of patients in each category.
Adding the immune therapy avelumab showed a trend of beneficial in median PFS, but there was no statistical difference, and the adverse reaction rate significantly increased, indicating that the addition of immune therapy is worthy of further exploration in this population.