Excerpts

The association between hypomethylation and TNBC status was highly significant in African-Americans ( p = 0.006), but not in Caucasians ( p = 0.70).

We observed an increasing trend in uterine-artery sparing RT in the endoscopic approach (R Spearman = 0.812, p = 0.006) and when all studies were evaluated together (R Spearman = 0.560, p = 0.016).

primary tumors showed a clear trend towards a higher LC probability for primary tumors ( p = 0.006).

Histology had a significant impact on local tumor control ( p = 0.039), showing highly significant differences between patients with prostate cancer and “other” (see patient characteristics, p = 0.007).

In a planned interim report of the FOxTROT phase III trial presented at ASCO 2020, investigating the efficacy and safety of neoadjuvant chemotherapy in 1053 T3-4, N0-2 colon cancer patients, relapse or persistent disease after two years showed a trend toward improvement at 15.6% for neoadjuvant chemotherapy vs. 19.5% for adjuvant chemotherapy ( p = 0.007) [ 43 ].

High-risk patients had a highly significant shorter median OS compared to low-risk patients (16.6 months (95% CI = 13.2–20.0) vs. 29.8 (95% CI = 21.7–37.9), p -value = 0.007) ( Figure 2 ).

ASCP was a highly significant prognostic factor for overall survival in univariable regression analysis ( p = 0.007) as well as in multivariable Cox regression analysis (HR 1.303; 95% CI 1.013–1.677; p = 0.039).

To eliminate possible discrimination due to outliers, a Spearman’s test was performed, confirming a highly significant correlation with β2M ( p = 0.008), plasma cell percentage ( p = 0.035), C-reactive protein ( p = 0.043), and serum calcium levels ( p = 0.038), as shown in Figure 3 A.

In detail, the intensity of tumoral HLA-I HC/β 2 -m surface expression correlated highly significant positively with the density of intra-tumoral CD8 + T cells ( p = 0.008 resp. 0.003), but negatively with the number of CD8 + T cells adjacent to FoxP3 + cells within a radius of 30 μm ( p = 0.009 resp. 0.007) ( Table 5 ).

In PC patients with a Gleason score of > 7, the inverse correlation was highly significant between baseline or radiation-induced NPB frequency with TL (r = −0.404; p = 0.008; r = −0.403; p = 0.008, respectively; Figure 3 E,F).

With a highly significant pathological complete response of 49% (versus 23% in AC patients; p = 0.008) and estimated 5-year survival benefit from combination chemoradiotherapy compared to surgery alone (AC: p = 0.049; SCC: p = 0.011), it is evident that this patient subgroup had a major benefit from this therapeutic intervention [ 10 ].

While overall survival was not different between the groups (HR 0.62; 95% CI 0.36–1.07; p = 0.09; I 2 = 80%;), the subgroup analysis of studies employing plastic stents showed a trend toward better survival in the RFA-treated group (HR 0.42; 95% CI 0.22–0.80; p = 0.009; I 2 = 72%).

Similarly, a significant trend towards better outcomes was observed with increasing Kawaguchi scores ( p = 0.009), with grade 1 tumors having a 51.7% lower probability of good outcomes compared to grade 3 ( Figure 4 and Figure 5 ).

When we performed a paired analysis with the corresponding normal tissues, a highly significant difference in H 2 O 2 production was found in BRAF + TERT ( p = 0.009), BRAF only ( p = 0.003), ALL BRAF ( p < 0.0001), RET or RAS mutated ( p = 0.02), and ALL MUT tumors ( p < 0.0001) but not in non-mutated PTCs ( p = 0.12) ( Figure 2 , panel B). 3.3.

A clear trend towards impacted antibody titers was seen with rising age ( r = −0.30; p = 0.0093).

They found in a multivariate analysis, laterality becomes highly significant ( p < 0.01) and that right-sided tumors have a worse OS than left-sided tumors (15 vs. 18 months; respectively) [ 39 ].

All the statistical analyses were performed via nonpaired two-tailed t -tests (a p -value < 0.05 was considered significant, and a p -value < 0.01 was considered highly significant).

A statistically significant difference was considered when p ≤ 0.05 and highly significant p ≤ 0.01.

In the combined model, stage and hydronephrosis emerged as significant clinical factors ( p = 0.03 and p = 0.01, respectively), while the three radiomics features remained highly significant ( p < 0.01).

Densitometric analysis revealed a highly significant delay in colony formation in ITIH5-expressing CCC-5 cells by 38.29 % ( p < 0.01).

A highly significant inhibitory effect ( p ≤ 0.01) on viability was observed for 2.5 μM CBD and for 5.0 μM THC and CBD when applied individually.

Cluster 10 consisted of 201 cells from both the Lin− and Lin+ cell populations from each patient, with over 1800 genes that were highly significant ( p value ≤ 0.01) ( File S3 ).

However, a clear trend was observed: patients who were prescribed more than 8 medications during hospitalization were at significantly higher risk of experiencing at least one DDI ( p < 0.01), emphasizing the importance of polypharmacy monitoring as a clinical risk factor.

In SEER, among those <55 years, incidence increased at a higher rate in women (AAPC = 3.22%, p < 0.01) than men (AAPC = 1.51%, p = 0.03), with non-parallel trends ( p = 0.02), while a decreasing trend was seen in both men (AAPC = −2.16%, p < 0.01) and women (AAPC = −1.37%, p < 0.01) of the ≥55 years group.

Of the nominally significant modules, lightsteelblue (r = 0.63, p = 0.01) and darkviolet (r = −0.57, p = 0.03) were of the most interest.