Excerpts

Additionally, though borderline significant, in patients that were diagnosed with pancreatic pathology at the age of 65 years or younger, COPD also correlated with IPMN (OR 4.4, 95% CI 0.98–19.79, p = 0.07).

Interestingly, females had statistically significant extended PFS compared to males, and although the impact on OS did not reach statistical significance, it was nearly significant ( p = 0.07).

Additionally, IGF1R mutations exhibited borderline significance (7.2% vs. 2.9%, p = 0.07).

Although alterations in PI3K, TGF-Beta, and RTK/RAS pathways were not statistically significant, borderline significance was observed in genes related to these pathways, including EGFR ( p = 0.07), FGFR1 ( p = 0.05), FGFR2 ( p = 0.05), and PTPN11 ( p = 0.05) in the PI3K pathway and SMAD4 ( p = 0.08) in the TGF-Beta pathway.

Positive PD-L1 staining determined at a threshold of 1% showed a trend towards improved survival in the entire cohort (70.3% vs. 57.4%, p = 0.07) in univariate analysis ( Figure 2 ).

The test for subgroup differences showed a trend toward statistical significance ( p = 0.07), thus no strong evidence of differential effects based on the method used to define sarcopenia was observed ( Supplementary File S6 ). - Overall survival (multivariate analyses, aHR): In the subgroup analysis for OS based on multivariate regression analyses’ reported outcomes, the pooled aHR for the 29 studies defining sarcopenia using SMI was 1.59 (1.40; 1.80), with substantial heterogeneity (I 2 = 79%, τ 2 = 0.06, p < 0.01).

The rate is markedly higher in patients with PSA > 0.15 ng/mL than in their counterparts with lesser PSA concentrations, but the difference only shows a possible trend toward statistical significance ( p = 0.07). 4.

Figure 5 B shows a statistical trend between a lower ADC value and PR or SD patients ( p = 0.07).

We observed a borderline significant link between G grade and recurrence ( p = 0.07) with a higher probability of recurrence for the G3 stage.

Moreover, SLeA overexpression showed a trend association with decreased OS in GC ( p = 0.07).

Moreover, SOX2-negative cases showed a trend for a longer survival time when compared to those expressing this factor (80 months (CI 69-92) vs 42 months (CI 25-59), respectively; HR 2,8; p = 0.07).

In addition, the MoRAL score showed the best calibration function with a non-significant p value ( p = 0.15) by the Hosmer-Lemeshow test; the WCM model and the AFP model, the second and third best models evaluated by c -index, were found to be less accurate with marginally significant p values ( p = 0.07, and p = 0.06, respectively).

The same trend was observed after 24 h (borderline significance, p = 0.07). 2.5.

We found that there was a significant trend towards decreased OS rising from 1 to 2 to ≥3 sites involved (mOS 23.6 vs. 15.5 vs. 11.6 months respectively, p = 0.07). 4.

Analysis of microbiome variation in relation to spatial distance between sampled tissues revealed a strong trend toward significance ( p = 0.07) with a substantial effect size (R 2 = 0.207).

In contrast, HALP at day +100 maintained and strengthened its association with PFS after adjustment (HR: 3.27, 95% CI: 1.45–7.38; p = 0.004), as did ΔHALP at borderline significance (HR: 1.97; p = 0.070).

The ypCR rate achieved was 25% versus 10.64% in favor of dose escalation, with no significant difference, but a trend toward significance ( p = 0.07).

Expression of miRNA-221 was not correlated with OS in the present patient cohort, however, in patients without neoadjuvant treatment miRNA-221 positive tumors showed a strong trend towards shortened OS ( p = 0.070) with a median OS of 64.0 months in miRNA-221 negative patients (95%CI not calculable) compared to a median OS of 22.1 month (95%CI 13.3–30.8 months).

Group C also had a higher percentage of dual T-cell depletion for GVHD prophylaxis using PTCy combined with ATG, at 76.2%; however, this was borderline significant (overall p -value = 0.07).

CKD before treatment showed a trend towards a lower overall response rate (ORR, OR 0.5, p = 0.07) in multivariable analysis (MVA) and inferior relapse-free survival (RFS, HR 2.16, p = 0.06) in univariate analysis (UVA), but not MVA (RFS, HR 1.93, p = 0.15).

CDX2 was near statistical significance for DFS (HR = 2.15, 95% CI (0.92–5.04), p = 0.070).

In contrast, male sex, allogeneic HSCT, hypertension, diabetes, BMI ≥ 25, and smoking were not independently associated, although hypertension showed a nonsignificant trend toward increased risk (OR 1.34; 95% CI 0.98–1.82; p = 0.07) ( Table 8 , Figure 4 ).

We next investigated the incidence of NPC between females and males and found 4.9-fold more NPC cases in males (n = 34) than females (n = 7), with a Chi-square statistic of a marginal significance ( p = 0.07; Figure 1 B).

However, it is striking that nuclear/cytoplasmic expression of β-catenin has not been shown by itself in this meta-analysis to be significantly associated with poor survival, although a marked trend of effect is shown ( p = 0.07); this result is probably due to the paucity of primary studies addressing this question (3 studies, 255 patients).

Regarding the diagnostic group, patients with primary tumors without axillary involvement showed a trend toward reduced recurrence risk (OR = 0.19, 95% CI: 0.03–1.47, p = 0.070), consistent with the expectation that localized disease has a more favorable prognosis.