Excerpts

These patients have a more unfavorable prognosis, which increases the likelihood of identifying a positive trend in an effective treatment, thereby confirming the crucial role of patient selection in postsurgical strategies.

Hence, DEX may mediate the remodeling of local RAS signaling, which may be significant in overall survival and disease-free survival.

Overall, in SKOV3 cells, short-term DEX exposure tended to reduce angiotensin receptor expression, whereas prolonged treatment showed a trend toward increased expression, although these changes were not statistically significant.

In this pooled analysis, the survival benefit of ICIs was only marginally significant (HR 0.84, 95% CI 0.70–1), and no pooled results were available by cancer type.

In a prespecified exploratory analysis of the CD16A-158 polymorphism (V, high-affinity; F, low-affinity), patients with the CD16A-158FF genotype showed a trend toward improved OS with margetuximab compared with trastuzumab (median, 23.6 vs. 19.2 months; HR, 0.72; 95% CI, 0.52–1.00).

The recent literature suggests an increasing trend in the development of oral cancer among rural populations around the globe [ 3 , 4 ].

Wide confidence intervals around several covariates and the borderline significance of myxopapillary histology illustrate this limitation.

The EMERALD-1 trial showed that the addition of durvalumab (anti-PD-L1) and bevacizumab to TACE significantly extended progression-free survival compared with TACE alone (15.0 versus 8.2 months; HR 0.77, p = 0.032), successfully meeting the primary endpoint and demonstrating a strong trend toward overall survival improvement [ 93 ].

Compared with MTAP wild-type tumors (median 63 years, IQR 55–69), patients with MTAP deletion showed a trend toward older age; however, this difference did not reach statistical significance (Wilcoxon rank-sum test, p = 0.069).

A statistical trend was observed only for patient age at DCIS diagnosis, with an increased hazard ratio for patients older than 50 years.

While the disease type ( p = 0.795) did not seem to impact on the outcome after AZA/DLI, the disease stage before transplant showed a clear trend.

The distribution of cancer types shows an increasing trend over the last few years.

Patients with a Sister Mary Joseph nodule showed a trend toward better survival outcomes.

19.7 months; HR 0.80; p = 0.018) and a favorable trend in OS (54.3 vs. 48.3 months) compared to those receiving the NACT-first sequence [ 17 ].

Positive margins were associated with higher local recurrence with marginal significance in all the patients.

HER2 YVMA overexpression in 4T1 models led to a nearly significant increase in the frequency of spontaneous brain metastasis, with 1/5 HER2-negative mice developing metastasis compared to 8/10 across the HER2-expressing groups (Fisher’s Exact Test p = 0.0889).

For progression-free interval, the high-BiScore group also showed an unfavorable trend, although the difference did not reach statistical significance ( Figure 4 D, log-rank p = 0.076).

While the result approaches statistical significance, it is based on only two studies limiting the strength of evidence.

Surprisingly, our data also show discordance between the overall response rate and PFS as there was no improvement in the depth of response in our meta-analysis, even with an anti-CD38 containing regimen, while we detected a highly significant PFS advantage with the use of daratumumab.

Non-mitochondrial respiration (Δ0.79 pmol/min/Norm; unit, p -value = 0.053) and maximal respiration (Δ4.01 pmol/min/Norm; unit, p -value = 0.097) showed a decreasing trend in tCM, yet no differences were observed in coupling efficiency between cCM and tCM ( Supplementary Figure S8 ).

In particular, our (near-significant) results regarding the analysis of adjuvant systemic treatment, as well as those of the separate analysis of subcohorts with different counts of treated metastases, could both benefit from larger sample sizes, in order to clearly define the potential influence of these factors on PFS and OS.

Higher M2 TAMs infiltration was associated with deeper tumor invasion (pT) and showed a trend toward advanced pTNM stage.

After the training period, trained cancer survivors showed a trend towards reduced DNA methylation age, but this was not statistically significant.

In the Cox regression model, HPV16 positivity showed a trend toward an increased hazard of progression to CIN3, although the estimate was imprecise and did not reach statistical significance ( p = 0.146) ( Table 2 ).

Significant prognostic predictors were identified, including PG-SGA symptom assessment (HR = 1.068, 95% CI: 1.001–1.131), disease status (HR = 2.054, 95% CI: 1.551–2.721), and GLIM handgrip strength (HGS, HR = 1.424, 95% CI: 1.175–1.725), while food intake showed borderline significance (HR = 1.124, 95% CI: 0.999–1.264).