Barely Significant

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a strong trendp=0.0551.1× alphagold
As TCF1 was also expressed by cancer cells, we assessed its prognostic impact and found that increased percentage of TCF1 + in cancer cells was associated with a strong trend for a worse DFS in the TC (HR:2.5, 95%CI:1.0-6.5 p=0.055), a trend that became significant when the TCF1 positivity was assessed in the IF (HR:2.1, 95%CI:1.0-4.4, p=0.045) ( Table 1 , Figure 1D ).
a negative trendp = 0.0551.1× alphagold
borderline significancep = 0.0551.1× alpha
The “ENTP6 and SMOC1” combination exhibited a negative trend with borderline significance (p = 0.055).
Although this difference did not quite reach significance (p=0.055), collectively the results indicate that T cell-dependent antibodies contribute to the overall protection induced against GAS-M1 following immunization with GAS-2W.M1. 3.3 The 2W Th cell epitope promotes an enhanced CD4 T cell IFN-γ response in GAS-2W.M1-immunized mice Children are more susceptible to superficial GAS infections than adults and this correlates with reduced IgG3 and IFN-γ production ( 20 ).
marginal significanceP = 0.0561.1× alphagold
Age ≤ 63 years (OR = 3.103, 95%CI: 1.035-9.306), CEA 6w Down (OR = 4.209, 95%CI: 1.287-13.758), and CEA 12w Down (OR = 7.267, 95%CI: 1.508-35.006) were significantly associated with higher DCR, while NLR 12w Down (OR = 4.682, 95%CI: 0.962-22.796) had marginal significance ( P = 0.056).
borderline significanceP = 0.0561.1× alpha
Nevertheless, the borderline significance of the adjusted malignancy risk (P = 0.056) suggested an emerging safety signal that would become more apparent during longer follow-up periods. 3.5 Secondary outcomes (2–6 years) Among 5,505 patients followed beyond 1 year (4,250 fast-exposure and 1,255 slow-exposure phenotypes), significant differences emerged in safety outcomes, while efficacy remained comparable ( Table 5 ).
a statistical trendP=0.0561.1× alphagold
Though a statistical trend due to the small number of animals (P=0.056 for gRNA and replicating virus titers, and P=0.095 for sgRNA), the hamsters in the recipient group housing with group 2 consistently had a log or two lower median gRNA, sgRNA, and replicating viral load levels in the lungs and oral swabs than those housed with group 1 ( Figure 3D ).
borderline significantp-value =0.0571.1× alphagold
In contrast, there was a borderline significant difference ( p-value =0.057) in the rate of SARS-CoV-2 RNA positivity when we used RT-real-time PCR on nasopharyngeal samples at the time of blood withdrawal ( Table 3 ), suggesting that spike protein-positive patients still had detectable viral load at the time of hospitalization.