Excerpts

However, comparing the efficacy of the combination relative to the efficacy of its separate components, we found that anti CTLA-4 + cisplatin had a marginally significant ( p = 0.057) synergistic effect relative to either anti CTLA-4 or cisplatin alone.

Conversely, BRY did not stimulate NK-cell activity but rather inhibited cytotoxicity in three donors (an example is shown in Figure 3 A), resulting in a nearly significant fourfold inhibition across all donors (Figure 3 B; P = 0.057).

No other group comparisons were significant, with only trending towards significance for vehicle-treated Tat(+) mice compared to MJN110-treated Tat(+) mice ( p = 0.057). 3.3.2.

Occurrence of a new miscarriage was higher and at the edge of significance (24 vs. 12%, p = 0.057) for RM patients with no dysregulation diagnosed.

A borderline significance was observed for anakinra use in the case group ( p = 0.057) ( Table 4 ). 4.

Shed P2X7R positively correlated with ALT (r = 0.269; p = 0.012) and negatively with BNP (r = -0.361; p = 0.007), indexes of liver and heart injury or stress, respectively, and, at near significance, with sNLRP3 (r = 0.218; p = 0.057) ( Table 6 ).

In contrast, there was a borderline significant difference ( p-value =0.057) in the rate of SARS-CoV-2 RNA positivity when we used RT-real-time PCR on nasopharyngeal samples at the time of blood withdrawal ( Table 3 ), suggesting that spike protein-positive patients still had detectable viral load at the time of hospitalization.

And a decreasing trend of GSH-Px activity was observed in the TS group over the CON group on AT7 ( p = 0.057).

The effect of UMC on asthma in the entire PASTURE population (aOR: 6.73, 95% CI 2.77–16.34, p < 0.001) was also present within the Finnish arm (aOR: 13.42, 95% CI 3.17–56.89, p < 0.001), and with borderline significance in the other centers (aOR: 3.99, 95% CI 0.96–16.63, p = 0.057).

Thus, CBT was associated with less neutrophil engraftment, but this was not quite statistically significant ( P = 0.057).

Vitiligo (n=10) significantly correlated with improved OS (HR=0.230; 95% CI: 0.057-0.936; p=0.040) and showed a trend for better PFS (HR=0.417; 95% CI: 0.169-1.026; p=0.057).

This expansion was near significance as compared to CVID subjects ( p = 0.0571).

Although a significant negative correlation was observed between IP-10 plasma levels and circulating CD4 T cells at M2 (rho = −0.49, P = 0.0282); such association was positive and borderline significant between plasma IP-10 levels and CXCR3 + CD4 T cell frequencies (rho = 0.43, P = 0.0574), and no association was observed between plasma IP-10 and the frequency of Th1Th17 CD4 T cells.

The layering of medical countermeasures resulted in statistically significant synergy in female mice immunized with P:Δ caf1 B:rF1-V ( p = 0.0017) or nearly significant synergy in female mice immunized with P:Δ yopD /Δ caf1 B:rF1-V ( p = 0.0575), using the Bliss independence model to calculate synergy scores ( 62 ).

A low dose of GM-CSF (0.2 μg/mouse, n=10) improved survival to 30% with a median survival of 11.5 days (95% CI: 6 – >21), showing a trend toward significance compared to placebo (HR = 0.485, 95% CI: 0.2232–1.054; p = 0.0577).

Interestingly, the LA-CSC group showed the lowest CD56 bright NK/CD56 dim NK ratio of all groups and a nearly significant trend to a lower ratio compared to the Spanish-CSC (p=0.058).

A decreasing trend in the pGsk3β ( p=0.058 ) compared to the group treated only with palmitate was also observed ( Figure 5A ).

A marginal trend toward a protective effect of increasing pollen concentration on sensitization was noted only in the lower-exposure stratum (OR = 0.994, 95% CI: 0.989–1.000, P = 0.058), which did not reach statistical significance ( Supplementary Table 2 ).

Analyzing the stromal compartment and thus excluding TLS-associated B cells, this effect was significant in the intratumoral region (p=0.047) and displayed a strong trend in the peritumoral region (p=0.058).

intracellulare -infected pre-AAT infused MDM + 10% plasma; the mean densitometry measurements normalized for β-actin showed near significance ( p = 0.058).

Stratified analysis by gender revealed that there was a statistically significant difference in CD3+CD4+ mitochondrial lymphocyte count in male patients (p = 0.014) and a marginal trend toward significance in female patients (p = 0.058).

The difference with and without parasites was marginally significant ( Appendix S1: Tables S12, S13 ; parasite:time estimate= 0.0135, P= 0.0583; Figure S5 ; Figure 2C ).

The decreases in MBP levels were also associated with increasing cognitive impairment index (CII) score but only approached significance [F(1,28)= 3.888, R 2 = 0.1219, p =0.0586] ( Figure 2C ).

By day 60, the survival curves of two vaccine groups were still significantly different from the control curve ( p = 0.010 for the E555 Δ ilvI group and p = 0.024 for the Hcp1 + CPS-CRM197 + E555 Δ ilvI -vaccinated mice); the survival curve for the Hcp1 + CPS-CRM197 group approached significance with p = 0.059.

In 2 trials (MLSPZV1 (Mali 1) (Mali, 2014) and MLSPZV2 (Mali 2) (Mali, 2016)), antibody levels were significantly higher in protected vs unprotected males and in one additional trial (EGSPZV3 (Equatorial Guinea, 2018)) the difference was borderline significant (p=0.059).