Excerpts

In 2 trials (MLSPZV1 (Mali 1) (Mali, 2014) and MLSPZV2 (Mali 2) (Mali, 2016)), antibody levels were significantly higher in protected vs unprotected males and in one additional trial (EGSPZV3 (Equatorial Guinea, 2018)) the difference was borderline significant (p=0.059).

Although the prevalence was higher in T1D, this did not reach significance ( p = 0.2069), but approached significance in males ( p = 0.0593).

Although patients with higher free AIM concentrations on day 1 showed a trend toward improved 30-day survival (p = 0.0595), statistical significance was not reached until day 8.

Although there was a significant increase in annexin-V-expressing HSA+ cells that were treated with birinapant and MG1 in comparison to cells treated with birinapant alone, this increase in annexin V+ cells did not quite reach significance ( p = 0.0596) ( Figure 5C ) when compared with the cells only treated with MG1.

Total alveolar nuclear counts were observed to be elevated in WT mice exposed to DE compared to WT mice exposed to saline (p=0.0377), with an observed trend of increased nuclei in KO mice exposed to DE compared to KO mice exposed to saline (p=0.0598) ( Figure 4H ).

Similarly, in the subgroup of patients with moderate atopic dermatitis defined as baseline IGA = 3, the Nu0.5 group showed a borderline significant decrease in IGA score from baseline (-16.7%, 95% CI: -31.3% to -2.0%, p = 0.06) ( Figure 2F ).

Furthermore, although the module-trait correlations in WGCNA were only marginally significant ( P = 0.06 and P = 0.07), downstream analyses, such as functional enrichment and immune cell association, strongly supported the relevance of these modules.

By contrast, the minor allele (T) of rs11203367 conferred a borderline significant increase in OR for anti-CCP-positive RA in HLA-DRB1*04 -positive subjects (p=0.06, Table 3 ), as visualized in Figure 2B (light blue bars for carriers versus dark blue bars for non-carriers).

Low-dose tofacitinib significantly extended survival of ALS mice compared to untreated control ALS mice in the intervention (6.2 day increase; p = 0.02) and cycle (7.3 day increase, p = 0.004) regimens and showed a trend towards improvement in the prevention regimen (p = 0.06; Figure 1B ).

Compared to MN, they showed comparatively lower 24-hour proteinuria excretion but with marginal significance (3.96 versus 4.63 g/d, P =0.060) and presented significantly less frequency of nephrotic syndrome (47.45% versus 72%, P <0.001).

Furthermore, the RNA expression of SRC was positively correlated with the protein expression (r = 0.67, p < 0.001) ( Figure 6P ), and the RNA expression of HSP90AA1 was positively correlated with the protein expression, and the statistical significance approached significant (r = 0.35, p = 0.06) ( Figure 6N ).

Following booster vaccination, we found a borderline significant (p=0.06) increase in anti-spike granzyme B responses, in particular anti-S1, in infection-naïve participants (S1 – M3 versus M6) ( Figure 3A ).

Adonis showed a significant difference with MSM status (unweighted p=0.002, weighted p=0.001) and a trend toward significance with HIV status (unweighted p =0.06; adonis with formula: distance matrix ~ MSM-status + HIV-status).

Responding patients displayed an increasing trend of this parameter at T1, which was not statistically significant (p=0.06, Figure 5B ).

Induction of IFN-λ3 upon MERS-CoV-nsp2 expression was near significance (p=0.06) ( Figure 1D ); whereby IFN-λ3 was not impacted by MERS-CoV-nsp5 ( Figure 1D ).

The increased spleen masses were statistically significant (n=3; p=0.009) whereas increases in length were near significance (n=3; p=0.060).

Only LV showed a trend towards significance (AUC = 0.602; p = 0.060).

While SBP and DBP did not correlate with triglyceride levels or age, we did observe a moderate, borderline significant negative correlation ( P = 0.06) between male sex and SBP but not DBP, indicating that systolic blood pressure of female CAD patients tended to be higher in our cohort.

In case of directional binary method, NLR showed a trend towards significant effect on OS with substantial heterogeneity ( Figure 4 ; HR 1.68, p = 0.06, I 2 = 59%).

A high CD8 + T cell signature score was associated with significantly improved OS (P = 0.06, borderline significance) and a strong trend toward better PFS ( Figures 5C, D ).

Second, the retrospective design and hospital-based case selection may limit the robustness of certain findings—for instance, the association between lactation duration and PRL levels showed borderline significance (P=0.06).

There was a nearly significant positive association between IAA and percent NK T-cells (adjusted p = 0.06) and a non-significant association of similar magnitude (based on the beta coefficient) for indole ( Figure 2B ).

In multivariate analysis, higher number of children at enrollment in female HIV-infected index partners showed a trend to reduced odds of HIV transmission to their sexual partner (OR 0.558, CI 0.302-1.030, p=0.06).

Also, two factors, number of relapses and CRS grade, were shown to have significant relations to MRD-negative CR ( p < 0.05, Tables 2 , 3 ), while the relation between CRS grade and CR was marginally significant ( p = 0.06, Table 3 ).

In the peritumoral area, higher frequencies of CD3 + or CD8 + T cells were linked to significantly longer DFS (p=0.0097), while an increased density of PD-1 + CD8 + T cells showed a strong trend towards a positive impact on DFS (p=0.06) ( Figure 5B ).