Excerpts

The first principal component (captured by changes in the intake of kilocalories, carbohydrates, disaccharides, sucrose, and added sugar) showed a borderline significant association with changes in leptin levels ( p = 0.060).

The overall heterogeneity, while moderate, approached significance with Cochran’s Q-test (Q = 15.08, df = 8, p = 0.06) and an I 2 statistic of 47% ( Supplementary Materials, Tables S27 and S28 ).

However, the three RGL1 variants linked to HBV reactivation in the discovery cohort demonstrated marginal significance ( p = 0.06) and consistent directional effects in the replication cohort ( Table 1 ).

Additionally, a clear trend of increased AUC ∞ /DW (613.46 ± 220.42 h*ng*kg/mL*mg, p = 0.060) and C max /DW (57.69 ± 22.19 ng*kg/mL*mg, p = 0.067) was also observed for SLCO1B1 DFs + PFs in comparison to IFs + NFs (530.36 ± 223.98 h*ng*kg/mL*mg for AUC ∞ /DW; and 49.59 ± 22.09 ng*kg/mL*mg for C max /DW) ( Table 3 ).

Using the fixed-effects model, we did not find a significantly greater FBG level reduction in the AGO group than SSRIs; however, a trend towards significance has been observed ( p = 0.06).

non-injured p = 0.031; Figure 7 B) and a trend toward significance in the caudal zone at 7 dpi (F 2,6 = 4.48, p = 0.06; Tukey test p = 0.051; Figure 7 B).

Interestingly, in LNCaP cells, we observed an almost significant increase in ROS content ( p = 0.06) after ALA compared to the control, concomitantly with a significant upregulation of the antioxidant enzyme SOD1 after 48 h.

A strong trend towards an absolute decrease in LVM was observed in the treatment group ( p = 0.06) [ 51 ].

For let-7e, association with amputation approached but did not reach significance ( p = 0.060). 2.3.

The Dunn–Bonferroni post hoc test indicated that the most notable difference in thyroid volume was observed between the CT and TT genotypes, although it was still just a trend toward significance ( p = 0.06). 3.

Similarly, ex vivo samples from IRL201805Res patients revealed a strong trend ( p < 0.06) at 72 h for greater intracellular expression of IDO when compared with Pbo at the same time-point.

Regarding type I IFNs, IFN-α exhibited a decreasing trend in the transfected and infected group compared to the infected group ( p = 0.06), while IFN-β expression was significantly downregulated in the transfected group ( p = 0.05; Figure 2 E and Figure 2 F, respectively).

The analysis showed a clear trend towards increased protein levels GRP78 in neurons of the SNpc; the content of GRP78 increased 1.4 times ( p = 0.06) 3 h after its administration compared with the control ( Figure S4 ).

The expression of LRb transcripts in the VMH/DMH was not significantly different between sheep groups; however, a trend close to significance ( p = 0.06) was observed in the Lean-R group.

CIRBP and CIRBP-SV1 expression were downregulated compared to the control siRNA (67.8% decrease, p = 0.015; 85.2% decrease, p < 0.001, respectively), and CIRBP-SV3 showed a trend towards decreased expression (43.4%; p = 0.06) ( Figure 7 C).

Pooled univariate analysis of these studies did not quite reach significance ( p = 0.06).

The expression of CHST4 tended to be associated with improved OS, with the lowest hazard and marginal significance (HR 0.12; 95% CI, 0. 01 to 1.15; p = 0.06) adjusted by age, sex, pStage, histological type, and pleural thickness. 3.

Alterations in ATM were more frequent among H/L patients (17.3%) compared with NHW patients (7.9%), a difference approaching borderline significance ( p = 0.06).

Examination of the model investigating the statistical interaction between STAT1 and TGFB2 showed that there was a borderline significant increase in HR for the TGFB2 high group of patients (HR (95% CI range) = 1.84 (0.97–3.46); p = 0.06) There was a significant increase in HR for the STAT1 high group of patients (HR (95% CI range) = 2 (1.08–3.71); p = 0.029), accounting for significant impact of age at diagnosis (HR (95% CI range) = 1.03 (1.01–1.05); p = 0.005).

Tissue MCP-1 also demonstrated a trend toward significance by health status ( p = 0.06), where unhealthy animals had higher levels ( Supplementary Table S5 ).

Hepatic HIF-1α mRNA expression increased in both CLD models, reaching significance in the toxic model, whereas it was borderline significant ( p = 0.06) in the BDL model.

In our experience, despite a statistical trend ( p = 0.06) in inducing IL6 protein expression in HTR-8/SVneo cells, a low-dose tacrolimus of 10 ng/mL was not sufficient to significantly induce the expression of this pleotropic cytokine in these EVT cells when cultured under nitrosative stresses in vitro ( Supplementary Figure S2 ).

That way, the intermediate- ( p < 0.0001) and high-stress ( p < 0.01) regimes both showed a significant relative reduction in the IVDs’ height (intermediate-stress: 26.1 ± 4.3% reduction and high-stress: 20.9 ± 1.7% reduction, respectively), and a strong trend was observed with the low-stress regime ( p = 0.06) ( Figure 1 b).

Dunnett’s post hoc testing after ANOVA revealed a significant preventive effect for ectoine and a clear trend for NADA ( p = 0.06). 5-Hydroxyectoine had considerably smaller effects that did not prove to be statistically significant, probably due to the sample size of n = 10. 3.

Serum 3α-diol content was also higher in males that were admitted to the ICU than in males that were not admitted and was marginally significant ( p = 0.06).