Excerpts

Furthermore, our analyses yielded a small negative relationship between the number of antihypertensive medications taken and depressive symptoms ( β = −0.006; 95% CI [−0.011, −0.001]; p = 0.012), and a positive trend with well-being ( β = 0.007; 95% CI [0.000, 0.015]; p = 0.046).

Using human genetic data from the 1000 Genomes Project, we calculated the DH value for the NOVA1 locus, which was nominally significant at p = 0.046.

All F1 hybrid females had a full-complement (four) of pouch young, whereas many non-hybrid females had less than four pouch young, and this reduction was marginally significant by a Fisher’s exact test ( P = 0.047).

Although of marginal significance, signalling entropy was higher in the CTCs from patients exhibiting resistance (Wilcox test P =0.047, Fig. 5e ).

Diversity at two amino acid positions in SERA2 (aa93 and aa95) showed nominally significant age effects (aa93: −0.12 mismatches per year, quasi-Poisson model, P = 0.047; aa95: −0.39 mismatches per year, quasi-Poisson model, P = 0.032), but their statistical significance did not survive multiple-testing correction.

Despite many molecular evolutionary investigations, the strongest evidence for molecular convergence thus far appears to be a marginally significant (FDR-corrected P = 0.0486) enrichment of sound perception genes in which convergent and parallel amino acid substitutions were observed 2 – 4 .

4d , red data, median change = −0.207 a.u., p = 0.005, signed-rank and HB tests), and the boundary separation showed a trend towards being smaller (Fig. 4e , red data; median change = −0.025 a.u., p = 0.049, signed-rank and HB tests; Fig. 4e is not significant).

Males had slightly more affected organ systems than females, although this was only nominally significant (mean and ranges: 3.55 [1–12] for males, 3.49 [1–11] for females; linear regression p = 0.049; Supplementary Fig. 1 ).

We identified seven outliers in the analysis of SmkInit and CD risk using the MR-PRESSO approach and the causal association became nominally significant after removing these outliers (beta=0.13, P = 0.049, Supplementary Table 3 ).

The Group × Time interaction was marginally significant [ F (2,89.432 = 3.123, p = 0.049].

By comparison, the relationship between spiral index and CCI was weaker in the coarse version of the task, which was reflected by a marginal significance ( p = 0.049, Spearman rank correlation) in monkey R, and non-significance ( p = 0.89, Spearman rank correlation) in monkey A.

Indeed, we observed a marginally significant correlation between irAE ROR and objective response rates 14 in anti-PD-1/PD-L1 therapy ( Rs = 0.44; P = 0.049; Supplementary Fig. 1 ).

The difference of the effect of average variability on choice consistency and confidence ratings is marginally significant (Δ β cons−conf = −0.39 ± 0.24, P = 0.049; Fig. 1 d), however, this effect becomes more pronounced when removing two participants with outlying confidence rating behavior (Δ β cons−conf = −0.53 ± 0.25, P = 0.02; Fig. 1 d and Supplementary Figs. 1 and 3 ).

Still, there was a marginally significant preference after a day (mean AUC = 0.51, t (82) = 1.99, p = 0.049), which did not remain significant after false discovery rate (FDR) correction for multiple comparisons (adjusted p = 0.056, q < 0.05).

Although the proliferative index of Acomys fibroblasts was not significantly altered in response to 150 μM H 2 O 2 (Tukey-HSD, t = 1.93, P = 0.916), after 48 h in culture, 300 μM exposure did produce a marginally significant decrease (18.95%) in EdU + cells (Tukey-HSD, t = 3.32, P = 0.0493) (Fig. 3a and Supplementary Table 6 ).

The sds3 G1-Cas9 was tested under conditions similar to the M and P crosses in the present study, but a marginally significant inheritance bias (67%, n = 176, Fisher’s two-sided exact test, p = 0.0495) of the w U6b-GDe element was shown only in one out of the four crossing regimes (F 0 Cas9-bearing female, F 1 trans-heterozygous female), whereas the same Cas9 isoline mediated significant bias of the kmo sgRNAs inheritance in all six combinations of parental crossing in our hands (Figs. 1 – 3 ).

Eight of the 13 ALFRED genes with a nominally significant association between RDGVs and AI in at least one cancer type in the ALFRED analysis ( P < 0.05; Fig. 2d and Supplementary Data 5 ) also had an enrichment of RDGVs in a matched cancer type compared to in controls ( P < 0.05, Fig. 3d ; Supplementary Data 6 ): ATM in colon and rectum adenocarcinoma (COADREAD), lung adenocarcinoma (LUAD) and in PRAD, NSD1 in OV, and TPCN2 in uterine corpus endometrial carcinoma (UCEC).

We found there was a slight trend of a decrease in the 3 dB cutoff frequency in L5 relative to L2&3 neurons ( p = 0.050, Fig. 4d ).

Differences between each group were determined to be significant using one-way ANOVA (* p < 0.05, significant; ** p < 0.01, *** p < 0.001, highly significant, the Multiple Comparisons by Tukey) or analyzed by unpaired two-tailed t -test (* p < 0.05, significant; ** p < 0.01, *** p < 0.001, highly significant).

In the scRNA-seq data, a nominally significant decrease in proliferating B cells (unadjusted p -value < 0.05) was also observed when comparing baseline samples with aggregated post-vaccination data (Fig. 5e ).

The minimum sample size requirement is based on experience and the fact that the observed differences between different conditions were statistically highly significant ( p <<0.05, Figs. 1 e, 2 d, 4 c, 7b ) and never at the borderline value of p = 0.05.

When the BA or the SPEI time series exhibit a significant trend (i.e., p -value <0.05, assessed with the Mann–Kendall test), we fit the model including the predictor time T .

In 23andMe research cohort, 45 out of 51 lead SNPs available (88.2%) replicated with a consistent direction of effect at a Bonferroni corrected significance threshold of 9.8 × 10 −4 ( P -value = 0.05/51) and additional 2 SNPs were nominally significant ( P < 0.05) (Table 1 and Supplementary Fig. 4 ).

AEI values were significantly elevated in T21 compared to controls in the PFC ( p = 0.01, linear regression), and showed a marginal trend in the hippocampus ( p = 0.05) (Fig. 5B ).

Clinical information of these patients was provided in Supplementary Data 1 , with no significant differences in HBsAg, antiviral treatment, liver cirrhosis status, tumor number; modestly significant bias in gender, age and tumor size ( p < 0.05); and significantly lower microvascular invasion (MVI), Barcelona Clinic Liver Cancer (BCLC) stages and Edmondson-Steiner (E-S) grades in AFP − HCC versus AFP + HCC ( p < 0.001).