Excerpts

Ultimately, LLII MOTS-c treatment showed a trend towards increased median (6.4%) and maximum (7.0%) lifespan and reduced hazard ratio (0.654); P = 0.05 until 31.8 months (Fig. 4m ).

AEI values were significantly elevated in T21 compared to controls in the PFC ( p = 0.01, linear regression), and showed a marginal trend in the hippocampus ( p = 0.05) (Fig. 5B ).

Nominally significant effects of diagnosis on AIs (i.e., with P < 0.05, but which did not survive multiple comparison correction), were observed for the fusiform surface area AI ( β = −0.005, t = −2.56, P = 0.010) (Supplementary Table 2 ), pars orbitalis thickness AI ( β = −0.003, t = −2.26, P = 0.024), posterior cingulate thickness AI ( β = −0.003, t = −2.1, P = 0.034), superior temporal thickness ( β = −0.002, t = −1.97, P = 0.049), and caudate nucleus volume ( β = 0.003, t = 2.24, P = 0.025).

Of the 75 SNPs found in whites, 34 (46%) were nominally significant at P < 0.05 in Japanese, with 18 at P < 0.0005.

A significant trend for reduction in neutrophil counts and increase in T-lymphocytes with each DOL was observed in both cohorts (Fig. 2C ) by repeated measures ANOVA ( P < 0.05), and confirmed by flow cytometry (Supplementary Fig. 3 ).

2a ), and 53 showed nominally significant associations in the CKDGen cohorts alone ( p < 0.05; Supplementary Data 4 ).

Among these 38 genes, 13 replicated at a Bonferroni significance level (Logistic Regression p < 0.0013) with directions of effect consistent with the discovery findings in a cohort of unrelated, non-Hispanic white Kaiser Permanente health plan members (6653 PrCa cases, 30,121 controls), and an additional six were nominally significant ( p < 0.05; Table 1 ).

The dust-induced RF in SSP126 shows a slightly increasing trend ( p < 0.05 from the MK test) that switches to a slightly decreasing trend ( p < 0.05 from the MK test) if future dust deposition remains at the historical value (Fig.

While none passed multiple testing correction, mainly because of a lack of power since we have a limited sample size in an analysis with thousands of parameters (clones), we could observe that the few clones that approached significance ( P -value < 0.05) were shared across patients only in PR group and enriched at 24 months post transplant.

T/F viruses with incompletely closed Envs were also more sensitive to sCD4, although this difference did not reach statistical significance ( P = 0.05; Supplementary Fig. 3d ); and we observed a significant correlation between cold and sCD4 sensitivity ( P = 0.0005; Fig. 1f ).

In total, 115/130 GEIs were nominally significant ( p < 0.05) and directionally concordant with estimates from the replication set (Supplementary Data 13 ).

For all nominally significant associations ( p < 0.05), effect sizes were strongly correlated when using imputed vs.

For the ΔHR ex trait, published resting HR SNPs at four loci were genome-wide significant ( SOX5 , RNF220 , SYT10 and PPIL1 ), while 25 additional loci were nominally significant (5 × 10 −8 < P < 0.05; Supplementary Data 2 ).

Although nest site showed a significantly positive Mantel correlation ( P < 0.01), the positive correlation showed no or only marginally significant differences from neutral model simulations ( P = 0.05; Fig. 3b ; Supplementary Table 1 ).

Although, we did not observe an exact replication, one variant (rs561732; p = 0.0012; beta = 0.006) was nearly significant after correction for multiple testing (Bonferroni correction for 47 SNPs; p = 0.05).

We considered a SNP-lipid association to be validated if (i) the SNP was significantly associated ( P < 5 × 10 −8 ) in the unadjusted BHS discovery GWAS; (ii) the direction of effect was concordant between the validation meta-analysis and the BHS discovery analysis; and (iii) the association was nominally significant ( P < 0.05; less conservative) or reached the Bonferroni significance threshold ( P < 2.34 × 10 −5 ) in the validation meta-analysis.

These contrasting trends for the two country groups are linked to their respective ISA expansion trends, with the NAI countries having a strong increasing trend over time (320.9 km 2 yr −2 , p < 0.01), which, again, is partly offset by a decreasing trend for the AI countries (−15.4 km 2 yr −2 , p > 0.05).

ClinVar data were downloaded as VCF (accessed 02.05.2022) and filtered for nominally significant single variants ( P < 0.05 in any phenotype model).

Notably, our data indicated a nominally significant enrichment ( P <0.05, 1 million permutations) of credible MPB SNPs in enhancer regions from DPCs (treated with dihydrotestosterone, DHT), which further supports the hypothesis that DPCs are involved in MPB aetiology 25 (Fig. 2; Supplementary Data 1 ).

Only the volumes of the caudate, corpus callosum and third ventricle achieved a heritability that was nominally significant in our sample (uncorrected P <0.05).

In total, 63 loci have shown at least marginal significance ( P <0.05) with ER-negative breast cancer.

Table 2 provides a list of the strongest associations identified across the entire data set, all highly significant (Bonferroni-corrected P <0.05).

We provided detailed RegulomeDB annotations in relevant cell types (e.g., hematopoietic multipotent progenitor cells, CD34+ hematopoietic progenitor cells, any primary B-cell, lymphoblastoid cell lines from 1000 Genomes [i.e., GM19238], K562, NAMALWA, BLaER1) for: (a) all index variants; and (b) credible set variants with nominally significant ( P < 0.05) functional probability scores.

All signals show at least nominally significant ( P <0.05) directionally concordant associations in the follow-up studies of clinically validated PCOS cases, with no significant heterogeneity by PCOS case definition ( Supplementary Table 2 ).

Among 15 associations with more than two instrumental variables (9 metabolites, 7 FinnGen outcomes), seven associations (3 metabolites, 6 outcomes) remained nominally significant ( P -value < 0.05) in MRPRESSO outlier test.