Excerpts

We made further important observations regarding the WHRadjBMI-derived variants: (iv) All 53 WHRadjBMI-derived variants had nominally significant effects on WHR ( P WHR < 0.05, i.e., no spurious associations, weakest WHR association observed in GIANT P WHR = 7.5 × 10 −3 , Supplementary Data 1 ).

Finally, for both the number of persons affected and monetary losses adjusted for inflation, a positive trend is observed over all periods of record.

In contrast, the number of fatalities is available for almost all flood events in the database and a negative trend of at least 1% per year is observed, even though it is only statistically significant for the period between 1950 and 2016 (see Methods section for statistical significance testing procedure).

Moreover, the normalized monetary value of losses after gap-filling no longer shows a significant trend for the whole period, and losses normalized by wealth increase by only 0.2% per year, while normalized by GDP decline by 0.1% per year.

Despite this, we observed only a modest (though highly significant) effect; intelligibility in mixtures clearly does not completely fall apart.

In this regression, the TCGA eQTL, coding transcript and ERG transcription factor annotations were all highly significant after adjusting for multiple testing, whilst the AR transcription factor annotation was also nominally significant (Supplementary Fig. 5 ).

We note, however, that we did observe nominally significant associations with several previously reported and newly identified POAG risk loci in this group.

We did not observe a major effect of USP48 depletion on RPA chromatinization upon induction of camptothecin (CPT)-induced replication stress, although a marginally significant increase of RPA foci was evident when both USP48 and FANCC were depleted compared to when FANCC was depleted alone (Supplementary Fig. 5e ).

However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig. 5 ), resulting in a more youthful metabolomic signature in heart.

By focusing on interactions in regions of borderline significant genetic associations, we were able to identify potentially physiologically relevant target genes of GWAS SNPs through functional rather than proximity considerations.

Similarly, human MDMs in which NOD2 was silenced showed a trend towards an increased phagocytosis (Fig. 8e ).

A considerable number of genes associated with stress response, including the ARR gene cluster involving resistance to arsenic compounds 35 , 36 , show a clear trend of expansion in the domesticated population (Fig. 3 and Supplementary Data 6 ).

4 ), and overall we see a negative trend between δ 53 Cr and total Fe concentration (Supplementary Fig. 2 ).

However, when normalized to protein input, mass spectrometric analysis of purified myelin demonstrated a highly significant reduction by >50% of nearly all classes of lipids in CMT rat myelin (Fig. 5c ).

Importantly, after PL therapy, the lipid-to-protein ratio in the myelin of CMT rats showed a strong trend toward normalization, although the majority of individual lipid classes does not reach significance compared with non-treated Pmp22 transgenic controls (Fig. 5c ).

Nevertheless, combined cutting-and-shuffling and stretching-and-folding strategies offer the potential to actively control the degree and rate of mixing, which may be significant in many physical systems.

Currently, an important trend in IR detection is the combination of IR sensing materials with silicon readout circuit, enabling larger number of pixels, higher frame rates and more complicated on-chip signal-processing functions.

Staining for Synaptobrevin-2, Syntaxin-1, and Munc18-1 showed a trend towards reduced intensity (19.3, 16.4, and 10.4%, respectively, not significant).

The ciprofloxacin-resistant group displayed a clear trend where conserved CR responses were strongly linked to mutations in efflux regulatory regions suggesting that gyrA drug target mutations had a limited effect on CS and CR.

A third transcript, MAP3K4 , showed a trend for a difference between the DM1 and UA groups in urine cells, but failed to reach statistical significance (Supplementary Fig. 5 ).

Klhl2 in CA1 pyramidal neurons did not reach statistical significance ( p = 0.07) but showed an increasing trend which is consistent with the Drop-seq data.

Our RNAseq data—in line with previous reports 24 —show that HNF4A expression shows only a marginal trend towards zonation (FDR PV_CV = 0.02, Log 2 FC PV_CV = –0.19).

Like HNF4α , overall TCF7L2 (FDR PV_CV = 0.008, Log 2 FC PV_CV = 0.3) shows only a weak trend towards zonation.

Where problems are indeed identified, there may be significant opportunities to apply some of the lessons learned here, namely, much greater stringency and specificity in reference molecular networks.

In the case of iC++, neurons that fired APs showed a trend toward higher photocurrent amplitudes compared with those that did not (Supplementary Fig. 1 ).