Excerpts

But on the level of the cis -effects on the expression of the gene mRNA, the intronic non-coding editing events have less nominally significant effects compared to those events located in the 5′UTR, exons and 3′UTR (Fig. 4a–c , right) where the general patterns of the effect directions were positive rather than negative, indicating that the presence of the non-coding RNA editing events at 5′UTR, exons and 3′UTR were more likely to increase the mRNA expression of the genes.

This effect is only weakly significant for revenues distributed to all households.

Pearson correlations between genes enriched in the PPC and genes enriched in the PCC show a negative trend, interpreted as spatial segregation (Fig. 2c , Supplementary Dataset 2 ).

However, assessing the functional effects of the trans -mCpGs using the BLUEPRINT data, we observed a highly significant positive association between cg19409579 methylation level and PRDM8 mRNA expression in naïve CD4 + T cells ( n = 127, ρ = 0.49, association p value adjusted for age and sex = 4.7 × 10 −9 , Fig. 3c ). cis and trans DNA methylation effects of an MS susceptibility polygenic score for the MHC The MHC has a complex long-range LD structure and harbors 32 independent genome-wide significant associations with MS 2 , including the haplotype with the largest MS-associated risk, HLA-DRB1*1501 .

5 ) although, a nonsignificant trend of recovery was observed at the perimeter and the area of the deformed tissue during the cardiac cycle as an index of ameliorating ventricular compliance (Supplementary Fig. 6 ).

In particular, the influence of MA ions on the octahedral tilt was investigated from n = 1 (without MA ions) to n = 4 ( n > 1 has MA ions) RPPs, from which we identified a clear trend between n and the strength of the octahedral tilt.

The fractions of the bulk proteins captured with iProChip showed an increasing trend correlated with cell numbers (Supplementary Fig. 15b ).

From this analysis, a clear trend was noticed that the helical sense mismatch effect was long-range, reaching a maximum at 3.7 nm (contour length) before quickly diminishing to zero beyond 4.5 nm (contour length).

Most low-income countries, and particularly those with already high concentrations, show an increasing trend from this source under all SSPs, highlighting the importance of counteracting.

We employed a fear conditioning memory test in which we observed a deficit at 9 months (a 7 month cohort showed a trend towards a deficit that was not significant, Supplementary Fig. 9H ).

This prediction was clearly borne out by the data: the measured change in FF had a strong trend as a function of the change in Δ r (y-axis vs. color-axis in Fig. 3 c), and the measured change in noise correlations had a strong trend as a function of the change in Δ r i Δ r j (y-axis vs. color-axis in Fig. 3 d).

Hence, the CDRR and CARR show a slightly increasing trend while the contact angle and sliding angle differences decrease gradually (Fig. 9c–e ).

After 2012, a decreasing trend was observed and only 4 deals were signed in 2018.

10c ), specific AIM+ cells (CD69+ CD154+) showed a trend for higher CCR5 surface expression than non-specific AIM− cells (CD69- CD154-), consistent with MHC II tetramers results (Fig. 3c ).

As inward Na v SheP current contributes to the plateau phase of AP, an increasing trend in AP duration (APD 80 ) was observed with higher I Na , albeit without any statistically significant difference (Fig. 1i ).

The phosphorescence spectra showed a trend of peak wavelength in the order of PZQN (590 nm) > PZDN (556 nm) ~ PZTN (554 nm) (see Supplementary Fig. 21 and Table 1 ).

In contrast to this, however, the THTG-hepatocytes transfected with AdshRhbdf2 showed a decreasing trend in PA-induced impaired insulin signaling (i.e., alteration of p-AKT, p-GSK3β, and p-FOXO1 levels) compared with AdRhbdf2-transfected THTG-hepatocytes (Fig. 5d and Supplementary Fig.

An Ultrafast bootstrap score of 95% was considered highly significant, as recommended by the software authors.

Over most regions, the 1-pentad onset flash droughts also show an increasing trend, especially in South Asia, Southeast Asia, and Central North America where the increase in the proportion of 1-pentad onset flash droughts is greater than 20% (Supplementary Fig. 6 ), indicating that more flash drought events develop within one week over these regions.

Over most regions the frequency of flash droughts, in general, does not show a statistically significant trend, and there is only a significant trend over the Mediterranean Basin, Central Asia, and Sahara (Supplementary Fig. 10 ).

Positive values of standardized test statistic Z MK indicate an increasing trend in the flash drought time series, whereas negative Z MK values suggest a decreasing trend.

Total mHTT transcript levels at both doses showed a trend of decreasing concentrations at 8 h (not significant).

MACS2 was run without modeling due to the lack of a sufficient number of highly significant peaks for the model to be constructed.

Furthermore, the same analysis on vCA1–PL5 ensemble pairs showed an increasing trend for the coactivation (Supplementary Fig. 7d–f ).

In our experiments, we observed an increasing trend of the onset potential from PyTTA-BPyDCA to PyTTA-TPA and to PyTTA-BPDA COF (Fig. 5g ).