Barely Significant

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borderline significantp = 0.051.0× alphagold
When two groups were defined a posteriori based on the insulin values of LDIGIT (120–150 min) , there was a borderline significant group by time interaction for PAI-1 ( p = 0.05; n = 49) and the change in PAI-1 was greater in the insulin-resistant group (177, 61 for HMD vs. 128, 52 ng/mL for HWD; p < 0.001) than in the insulin-sensitive group (137, 80 for HMD vs. 113, 39 ng/mL for HWD; p = 0.02).
almost significantp -value = 0.051.0× alphagold
There were no significant differences either in the estimated 14-MEDAS scores between the different age ranges (18–24 years, 6.25 ± 1.73; 25–34 years, 6.09 ± 1.97; 35–44 years, 6.16 ± 2.03; 45–54 years, 6.72 ± 2.18; 55–64 years, 6.14 ± 2.24; 65–81 years, 5.89 ± 2.09; p -value = 0.418) although we detected a small and almost significant negative correlation between age and 14-MEDAS ( r = −0.1, p -value = 0.05).
nominally significantp -value < 0.051.0× alphagold
Evidence Classification and Quality Assessment Each unique association that was nominally significant ( p -value < 0.05) was classified as strong evidence (Class I), highly suggestive evidence (Class II), suggestive evidence (Class III) or weak associations (Class IV), with regard to epidemiological validity criteria ( Table S2 ) [ 21 ].
nominally significantp < 0.051.0× alphagold
After false discovery rate ( FDR ) correction, pathway enrichment analyses for genes harboring nominally significant ( p < 0.05) probes identified 44 significant pathways ( q < 0.05), and 5 pathways were related to lipid metabolism.
borderline significancep = 0.051.0× alpha
In the multivariable-adjusted analysis, sodium (adjusted odds ratio [OR] 0.89, 95% confidence interval [CI] 0.82–0.96; p = 0.004) and potassium (adjusted OR 0.87, 95% CI 0.77–0.99; p = 0.04) remained significantly associated, while phosphorus showed borderline significance (adjusted OR 0.64, 95% CI 0.41–1.00; p = 0.05).