Excerpts

PennCNV showed a trend at the PARK2 locus (p = 0.04; Figure S1A ) that was not significant after correcting for multiple tests.

Although the difference, evaluated by the Mann-Withney test, did not reach statistical significance (except for schedule 1, day 14, p = 0.04), we observed a striking higher emission in the toxin treatment group with respect to the control arm.

Hypsodonty shows no relationship with time in either clade ( Table S4 , Dataset S2 ), but ANCOVA shows the observed difference in the intercepts is marginally significant ( p = 0.04, Figure S5 , Table S3 ), meaning that Karnimata species have higher tooth crowns than the “ Progonomys clade”.

Further none of the secondary variables did show any significant differences from placebo apart from MMTT AUC C-peptide 0-4h and GGI AUC Glucose0-1h which showed mechanistically contradictory borderline significant effects of p = 0.04 and 0.045 respectively (Fig F in S1 File and Table 2 ).

In terms of performance, there was a marginally significant decrease in overall performance (from 63% to 51%; z = 2.01; p = .04).

There was also a significant trend towards increased carriage with number of inhabitants (i.e. 4 or more occupants per room) in a household (χ 2 = 4.3, p = 0.04).

In addition, we observed a nominally significant association (p = 0.04) with rs11209026, which is in agreement with the previously described effect on AS of the IL23R locus (Supporting Table S1 ) [4] .

Sex, expressed as the percentage of a model-building group that was male participants, was marginally significant and low fit (p = 0.04, r 2 = 0.01).

When all embryos within each string were genotyped, four strings (11, 16, 21 and 22, Table 1 ) still displayed a significantly skewed distribution, although one (brood 22) was of marginal significance (χ 2 , p = 0.04) and was not significant when only the two most successful sires were considered.

Concerning PFS, no significant association was determined when analyzing all three allelic variations (chi-square = 4.2, P = 0.12), although a significant trend was detected (chi-square = 4.1, P = 0.04).

This difference was significant for the Runner group [t(9) = -3.105, p = 0.012] but barely failed to reach significance for the Team sports group [t(9) = -2.392, p = 0.040 uncorrected, with an alpha adjusted to 0.025].

While the change in performance across the five days was highly significant for the congruent group (F(4,24) = 14.158, p<.0001, one-way repeated-measure ANOVA), the performance change was only moderately significant for the unisensory group (F(4,24) = 2.938, p = .04) and marginally significant for the incongruent group (F(4,24) = 2.937, p = .053).

A marginally significant difference in 16S rRNA copies per gram was detected at 0 dpi between non-MH (log 10 10.8±0.4 copies/g) and MH pigs (log 10 11.3±0.4 copies/g) (Kruskal-Wallis, P = 0.04) ( Figure S2 ).

None of the SNPs showed significant associations in cases with non-operable tumor stage, with the possible exception of 5q11.2-rs889312 which showed a marginally statistically significant association (adjusted P = 0.04).

Although there were statistically marginally significant differences observed with respect to week 16 cholesterol and non HDL cholesterol (p = 0.04 and p = 0.03, not corrected for multiple comparisons), within each arm there were no significant changes from baseline.

For both the 80°C and 90°C burns there was a strong trend of increasing perfusion with time post-burn, with B/N ratios at day 7 significantly higher than at 24hrs and day 3 (p ≤ 0.04, p ≤ 0.03). 4 Discussion An effective burn model must have reliable and consistent tissue injury.

With the no-schooling group as the baseline, the subjects with a “primary education” were positively associated with total cost at a borderline significance level (estimated coefficient = 1579.521, p -value = 0.040).

A borderline significant association between STIM1 polymorphism rs1561876 and BASFI ( P -value = 0.04) or BAS-G ( P -value = 0.06) was found.

SIRT1 rs3758391 T allele showed nominally significant associations with depressive disorders (OR = 1.19, 95% CI of 1.01 to 1.40, p = 0.040, see Table 3 ), metabolic syndrome (OR = 0.88, 95% CI of 0.80 to 0.97, p = 0.01, see Table 3 ), insulin resistance index (beta = -0.26, 95% CI of -0.48 to -0.04, p = 0.019, empirical p = 0.02, see Table 3 ) and blood glucose (beta = -0.05, CI of -0.09 to -0.002, p = 0.04, empirical p = 0.04, Table 3 ).

The subdistrict area with the highest incidence rate showed little BC disparity among the 5 years considered, whereas the township area with the lowest incidence rate expressed a significant trend increase ( P = 0.040).

Phyla-level phylogenetic binning of 16S rRNA data revealed a nominally significant correlation between the Bacteroidetes:Firmicutes ratio and age- and sex- adjusted BMI (r = 0.116; p = 0.04), but no significant correlation with metabolic syndrome traits [fasting glucose (r = 0.075; p = 0.19), systolic or diastolic blood pressure (r = 0.016; p = 0.78 and (r = 0.043; p = 0.45), respectively), fasting triglycerides (r = 0.078; p = 0.17), HDL-cholesterol (r = −0.052; p = 0.36); all adjusted for age and sex) Results from unweighted UniFrac analysis [16] also did not distinguish among the subjects based on BMI ( Figure S5 ).

However, at one month, a strong trend between reduced AD in affected nerves and RNFL thinning and mfVEP amplitude attenuation in affected eyes at six months (RNFL: R = 0.38, p = 0.04; mfVEP: R = 0.41, p = 0.02) was observed.

At rs1477798 in 15q22.31 which showed evidence of linkage in clinic-based, larger families, a nominally significant case-control association was observed (OR 1.16, p = 0.04) which was modestly strengthened for cases with CRC family history (OR 1.24, p = 0.03); however, no significant difference in risk by family history was observed and associations were far from genome-wide significant.

In a multivariate analysis, adjusted for occurrence of graft-versus-host-disease, Cytomegalovirus serostatus and duration of neutropenia, paired presence of the TLR4 1063A>G and IFNG 874T>A single nucleotide polymorphisms showed a trend towards increased susceptibility to invasive aspergillosis (p = 0.04).

In our study, although the association between lesion load and WM volume did not reach the 0.01 significance level that we set, it showed a trend toward a negative correlation between the two ( r = −0.27, p = 0.04).