Excerpts

A small trend towards increased Fgf21 expression was noted, however, in fasted mice, ad libitum fed mice, and ad libitum fed LPS-injected mice.

Fasting plasma glucose and insulin measured at the start of glucose tolerance testing (GTT) did not differ between genotypes ( Figure 4C ), although there was a strong trend for increased fasting plasma insulin concentrations in CD1d −/− mice, consistent with a trend to increased insulin resistance.

Finally, in this study, the present results were only statistically marginally significant, although association between regional rest-CBF and creativity was seen in the region having an a priori hypothesis.

The shape of these egg clusters showed an evident trend from kidney- to banana-like; the more curved and relatively more elongated and narrow the more numerous were the eggs inside.

In this light, it may be significant that one of the two T. tenax GINS homologs (TTX_0578, GINS15) is encoded within an operon with the catalytic subunit of primase, which is found in many, but not all, Archaea [82] .

Furthermore, there was a strong trend towards prevention of bacteraemia, with only 1 of 6 recipients of immune serum developing bacteraemia compared to 5 of 6 recipients of control serum by 18 h post-pneumonia challenge ( Fig. 7B ), similar to the data obtained with actively colonised mice ( Fig. 2B–2D ).

A highly significant inverse relationship among all transgenic lines was noted in which the greater were the levels of global SUMOylation, the less was the extent of infarct damage in the brains of animals exposed to permanent middle cerebral artery occlusion (pMCAO) for 24 hours.

Interestingly, while this baseline scoring already showed a trend that the nest building ability is impaired in Pum2 XE772 mice, the effect was much more pronounced in animals that underwent surgery for EEG recordings.

Note, that the results of the comparison remained highly significant even after the adjustment.

The number of seeds per pod and seed mass showed a low variability and a marginally significant population effect ( Table 2 ).

Total pod infestation rate in late June (by both weevils and moths) was mainly due to the infestation rate by weevils, and consequently showed a highly significant population effect and no region effect ( Table 2 , Figure 2D ).

Having a household contact with TB symptoms was borderline significant for MDR disease ( Table 2 ).

There was a significant trend between the number of risk alleles and the magnitude of BMD loss, with patients carrying the most risk alleles having the greatest loss.

A post-hoc analysis of the ACTG A5164 study showed a trend towards a better outcome for patients presenting with PCP starting cART in the early treatment arm, although statistical significance was not reached (p>0.05).

As shown by Gatesy [17] , a strong trend toward reduced caudofemoral mass can be seen in the lineage leading to modern birds.

By comparing to a background set of 41,906 human promoters and running against known cell cycle associated transcription factor binding sites the analysis suggested a highly significant association of E2F matrices among these genes ( Table 2 ). 8 out of the 10 most significant matrix associations were all E2F binding sites, especially E2F1 ( Table 2 ); which suggests a common regulatory mechanism among these 26 genes.

Proximity prestige was also significantly negatively correlated to degree centrality in two study years, but this correlation was marginally non-significant in 2002 after sequential Bonferroni-correction (with α = 0.017).

Here, the patient showed highly significant gray matter volume decreases within portions of the left temporopolar cortex (MNI coordinates: −39, 13 −22; cluster-size of local maximum 687; T = 16.30; Z = 6.54) and a region in the border of right posterior parahippocampal and lingual cortex (MNI coordinates: 25, −55, 1; cluster-size of local maximum 700; T = 15.62; Z = 6.45).

There was a highly significant rank correlation between terpene levels at day 35 and beetle colonization in individual trees.

However, in the same study it was reported that the length of time a person smoked was significantly associated with GATA5 DNA methylation, while the former smokers showed a trend towards statistical significance of more frequent GATA5 DNA methylation [33] .

In this light, we present a pathway and network oriented GWAS analysis (PANOGA) that challenges to identify individually modest genetic effects by combining nominally significant evidence of genetic association with current knowledge of biochemical pathways, protein-protein interaction networks, and functional and genetic information of selected SNPs.

The lack of a clear trend in these results suggests that the pattern of spiking during persistent stimulation is unlikely to be the basis of a discriminatory mechanism.

For both the host gene and the HOX gene cluster case we found a highly significant correlation between the expression of the gene(s) and the miRNAs that are linked to their co-transcription.

Despite the small sample size due to the unavailability of tissue, the 1.7-fold decrease in AβPP/AβPPα in neocortex approaches statistical significance.

There is a strong trend toward increased soluble Aβ 1–40 in lysates of FXS brain samples ( Figure 6D ) while AβPP/AβPPα levels are reciprocally decreased ( Figure 6C ) in both the neocortex and hippocampus.