Excerpts

2 B), the difference observed for the feature “variance” was highly significant (8.25 vs 8.94 vs 9.61; p = 0.0031).

Among them, SPL14 exhibited a highly significant decrease in hybridization density during the transition, (6.7-fold reduction, P = 0.0031, Figs.

There was a highly significant association between the p.R279C variant (rs117068593) and PDB in the sequenced samples compared with 1000 Genome controls (OR = 0.60; 95% CI = 0.43–0.84; P = 3.1 × 10 −3 ) and when compared with NHLBI controls (OR = 0.50; 95% CI = 0.38–0.67; P = 2.0 × 10 −6 ).

Comparison of patient groups based on nuclear CKS2 expression led to a highly significant ( P = .0031) but somewhat smaller separation of 34% between the groups ( Figure 5 D ).

Overall, the differences in numbers of up- versus down-regulated transcripts in responders versus non-responders were highly significant, whether considering only the number of transcripts with a significant difference at baseline versus 3 months ( n = 8, p = 3.10 -3 , Fisher's exact test) or considering the complete set of transcripts and associated trends ( n = 20, p < 10 -4 by Fisher's exact test, or p = 0.007 by analysis of variance).

These associations did not reach statistical significance in the individual groups, except for uDNA in Group A ( p = 0.0031).

Patients with BD showed a highly significant decrease of the white matter ROI volume (p = 0.0031), validating the findings of the meta-analysis.

In addition, compared to control, higher doses (2.5 and 5 mg/kg) of MDMA produced a nonsignificant trend to reduce the total duration of social behavior, while morphine increased the total time ( p = 0.0031).

Indeed, the treatment effect on the primary endpoint (CSMS(n)) was statistically highly significant ( p = 0.0031), with a trend for a significant difference in the treatment effect of −0.39 (95% CI, −0.64 to −0.13) points based on the subgroup analysis in the observed data, exceeding the 0.25‐point threshold.

In the K-M curve, the influence of high- and low-risk group on survival reached an extremely significant level (P-value < 0.0031) ( Figure 7A ).

We observed similar results when performing the enrichment analysis for the Segway segmentation track of GM12878 ( S4 Table ): strong enhancers were the most enriched (p < 0.0001); weak enhancers and active promoters did not achieve significance at the Bonferoni threshold (p = 0.0031 and p = 0.0419, respectively).

As shown in Supplementary Figure 2 , high scores for cluster_2 and cluster_3 were significantly associated with poorer survival outcomes (p < 0.001 and p = 0.005, respectively), while cluster_0 also demonstrated an unfavorable trend (p = 0.0031), highlighting their potential prognostic relevance. 3.4 Reconstruction of malignant epithelial cell differentiation trajectory To further investigate the transcriptional heterogeneity and differentiation dynamics of malignant epithelial cells, a pseudotime trajectory analysis was conducted.

Of the 100 targeted IR genes, 40 were shown to have significant SNPs (uncorrected p < 0.05), including the gene FCAR , which was nominally significant ( p = 0.0031).

Further, the difference is highly significant (p=0.0031, linear mixed effects model that controls for unit and subject effects), and quite sufficient for decoding.

Among these miRNAs, downregulation of miRNA-215 expression was highly significant in the STOP-IM group (plasma miRNAs, p = 0.00311 ( Table S1 ); exosomal miRNAs, p = 0.00039 ( Table S2 )); therefore, we concluded that plasma miR-215 expression mirrors exosomal miRNA expression and focused on expression of this miRNA for further study. 2.2.

T ‐statistics and uncorrected p ‐values are shown, bolded p ‐values are those that survive correction for multiple comparisons, italicized p ‐values are those that do not survive multiple comparisons correction but were nominally significant (i.e., .05 > p > .003125).

Increasing the spinning nozzle voltage (collector voltage = −3 kV) results in a highly significant decrease in fiber yield on the collector to 59% ± 9.1 at a distance of 10 cm ( p = 0.0032).

Males had a significantly higher Physical Functioning (PF) score ( P = .0163, 95% CI −4.315 to −0.4628) and a highly significant difference was seen on the Bodily Pain (BP) item ( P = .0032, 95%CI −10.56 to −2.269) ( Figure 1A ).

LTA was of borderline significance (p = 0.051) in the multivariable model once BOT D50% was included, although it was highly significant (P = 0.0032) without BOT D50% in the model.

The difference in OS between the matching patients and our cohort is highly significant (median overall survival 22.7 months vs 31.1 months, P = 0.0032, Fig. 2 ).

Moreover, the increase in the network efficiency in the dual-mode stimulation group was noticeably significant compared to those of the rTMS-only group (group∗time interactions: weighted network efficiency, F 1,22 = 10.91, p = 0.0032; binary network efficiency, F 1,22 = 9.80, p = 0.0049, Supplementary Table 1 ). 5.

Heart rate showed a trend towards a difference between groups and an interaction with time (Repeated measures ANOVA, Effect of Time: F 1,56 = 9.46, η 2 = 0.0082, p = 0.0032; Effect of Group: F 1,56 = 3.60, η 2 = 0.57 p = 0.063; Interaction F 1,56 = 3.45, η 2 = 0.003, p = 0.069).

Inter-comparison of VEGF expression in the epithelium between KCOT and DC revealed statistically highly significant results with the P = 0.0032 [ Table 1 ].

In line with this, a correlation analysis between NO and AsPgb expression revealed a negative trend across the full time course ( r = −0.32); however, this became stronger at intermediate stress stages ( r = −0.40) and became highly significant at 40%–45% sRWC ( r = −0.98, p = 0.0032).

However, the difference in proportion of anti-CCP-positive individuals in Hispanics and Caucasian is highly significant using the binomial test (two-sided exact p -value = 0.0032).