Excerpts

Random intercept for Participant was significant [β = 1.728, SE = 0.086, 95% CI = [1.56, 1.90], t (47.99) = 20.117, p < 0.001] and fixed-effects factor WordOrder was highly significant [β = −0.098, SE = 0.035, 95% CI = [−0.17, −0.03], t (808.19) = −2.78, p = 0.006].

There were no significant results, although there was a trend toward significance of ApoB < 5thCent ( n = 12) having a lower BMI ( p = 0.006; BHC p = 0.095) (Supplementary Table 16 ).

Proportions of nonclassical monocytes were lower amongst this higher income bracket with lower intermediate monocytes trending towards significance [nonclassical fold change -5.23 (95%CI -8.94 to -1.53), p = 0.006; intermediate -1.91 (-3.91 to 0.10), p = 0.063].

Our generalized estimating equations analysis revealed a decreasing trend in volume, fitting a quadratic function ( p = 0.006).

5k ) as compared to their counterpart mice bearing the fecal microbiota from HFHS-C donors, which was highly significant (post-hoc analysis: p = 0.006) at the 15 min peak of insulin secretion), and further illustrated by calculation of the GSIS during the peak of insulin response (Fig. 5l ). 16S rRNA gene sequencing of the gut microbiota composition revealed that FMT-HFHS-PM mice had greater alpha diversity than FMT-HFHS-C mice, represented by Shannon and Simpson’s reciprocal indices, consistent with data from donor mice (Fig. 3f, g and 5m–n ).

The association between sedentary behavior and elevated TyG-WC was highly significant in both the low activity group (β = 2.0217, 95 % CI [0.5801 to 3.4634], P = 0.0060) and high activity group (β = 3.8573, 95 % CI [2.3018 to 5.4128], P < 0.0001), but not significant in the middle activity group (β = 1.2830, 95 % CI [−0.1006 to 2.6666], P = 0.0692).

30.67 ± 3.59 kg/m 2 ; p = 0.073); overall, in the group treated with Dapa, the diminution of BMI was highly significant (32.04 ± 4.49 vs. 31.40 ± 4.18 kg/m 2 ; p = 0.006); in patients treated on Empa 10 mg+metformin, the reduction in BMI was significant (34.64 ± 5.80 vs. 33.14 ± 5.70 kg/m 2 ; p = 0.002); in patients treated with Empa 25 mg+metformin, the decrease in BMI was insignificant (33.45 ± 3.82 vs. 33.22 ± 3.84 kg/m 2 ; p = 0.421); overall in the group treated on Empa, the decrease in BMI was significant (34.16 ± 5.08 vs. 33.17 ± 4.99 kg/m 2 ; p = 0.002) ( Figure 4 ).

For individuals with tertiary education, the improvement was highly significant (T = -15, p = 0.006), while participants with primary or secondary education also showed meaningful progress (T = -7.89, p = 0.042).

We observed no differences between patients and controls in the brightness induction test ( t 39.8 = 0.534, p = 0.60, d = 0.115; Figure 2A ), but we did observe a highly significant difference between groups in the contrast suppression test ( t 35.2 = 2.902, p = 0.006, d = 0.663; Figure 2B ).

At six weeks, a significant trend for haloperidol was observed on the PANSS positive score (18.2 ± 5.90 vs. 21.3 ± 2.51, p = 0.006).

Adding interaction terms for interferon plus lopinavir/ritonavir, interferon plus ribavirin, and lopinavir/ritonavir plus ribavirin in the Cox‐PH regression analysis showed a trend toward synergy between interferons and ribavirin in the full dataset (AHR = 6.04, P = 0.006; Figure 3 ), as well as in the additional analysis taking in quality assessments to account for potential bias: respiratory data limited to drug quality and in data limited to only viral load quality 1 data ( Figure S4 , Figure S5 ).

The age factor was found to be highly significant to the tune of 9.85 times higher among older patients ( p <0.006).

Although this improvement was greatest between Visits 1 and 2 and then declined slightly between Visits 2 and 3, this was still a highly significant improvement from baseline to study end (p=0.006; Table 1 ).

However, there was a highly significant correlation between intrarenal and urinary miR-21 levels in the HTN group ( r = 0.831; P = 0.006), but not the IgAN group ( r = 0.259; P = 0.11).

There was a highly significant association between mean survival time and receipt of chemotherapy ( P = .006).

Concurrently with the group comparison, domains were also compared: in the psychological domain, the walking group exhibited a highly significant improvement (F = 28.89, p < 0.006).

A Fisher’s Exact analysis determined the risk of death within 30 days of operation in COVID-19-positive, ASA grade 3 to 5 patients was highly significant; OR 8.9, 95% CI 2.2 to 36.1, with a RR 7.5 (95% CI 2.2 to 25.7), p = 0.006.

A conditional (fixed-effects) logistic regression model, adjusted for the aforementioned covariates, demonstrated that the association between having seropositive adults and younger individuals in the same house was highly significant (OR: 49.1; 95% CI: 3.1–784, P = 0.006).

Most variables were not significant predictors of early RTS, except for the RASS approach, which showed a trend towards significance (estimate: 1.102, p = 0.006).

ABO C-R Eval scores showed a weakly significant association with treatment duration ( r = 0.162; p =0.006), while CCA scores were moderately associated with treatment duration ( r = 0.451; p < 0.001).

In MS patients, none of these correlations survived the FDR correction, but butyrate and valerate concentrations showed nominally significant positive correlations with TNF (rho=0.374, p=0.006 and rho=0.370, p=0.006, respectively).

The primacy/recency ratio increased in parallel with omnibus scores [ r = 0.25, t (189) = 3.55, p < 0.0005] and, consistent with previous results (Capitani et al., 1992 ; Golomb et al., 2008 ), showed a strong trend toward decline with increasing age [ r = −0.20, t (189) = −2.81, p < 0.006].

ACR showed highly significant association with the need for inotropes ( P =0.006) and Multiorgan dysfunction ( P = 0.004).

Crucially, our multivariate regression model demonstrated that a composite favorable response—defined by concurrent achievement of QRS narrowing ≥20 ms, LVESV reduction ≥15%, and LVEF improvement ≥10% at 6–12 months—was a highly significant predictor of event-free survival (Overall model p = 0.006).

Immunofluorescence revealed highly significant changes in the CK network within amniocytes with dense CK aggregates and retraction from the cell periphery (all p = 0.006).