Excerpts

However, these differences did not reach statistical significance except for the caproic acid (hexanoic acid), which was less abundant in the HIV+plaque+ group (p=0.049).

Among the sepsis patients, the association between delirium and the risk for mortality was weakly significant (nondelirium vs. delirium: 9.1% vs. 47.1%, p = .049) ( Table 1 ).

While rhPRG4 treatment showed a trend towards a reduction in PL IL-1β at 24h in Prg4 GT/GT animals, this trend was not statistically significant ( p>0.05 ), due to a high degree of variability in calculated IL-1β concentrations in specimens from the same experimental group.

Similarly, a negative trend was observed for LN SIV-RNA levels at M1 and both LNMC and PBMC TFV-dp levels at M1 (ρ <-0.37, P ≤0.05, n=21).

The anti-VHSV antibody titer in serum demonstrated an increasing trend from 48 hpiv in the immersion group, which remained significantly ( p < 0.05) higher than that of the NVC control group throughout the immunization period, with further enhancement of the titer at 48 hpc with VHSV.

The TCR/BCR diversity of CD8m T (GZMH), CD8m T (GZMK), and memory B was negatively correlated with age (R<0), while that of prolif T and plasma had a positive trend with age with no significant (p>0.05; Figure 4D ).

However, some members of the Apolipoproteins, Pentraxin, and Parvalbumin families showed highly significant ( p <0.05) abundant levels ( Figure 9B ).

We selected eight pathways from each database that reflected macrophage function and may be related to OA pathogenesis with the most highly significant p-values (p<0.05) from each database..

We found that AC016876.1 showed marginally significant lower expression in Basal-like than Her2 patients with uninvolved lymph node (stage ;N0; P=0.05; Wilcoxon test; Figure S1H ).

However, the mouse FcμR domain shows a marginally significant lower Tm than human FcμR ( p = 0.05).

Anti-asexual stage IgG antibody levels post infection were not statistically different between infection routes SPZ Gct and BS Gct (p=0.22), and borderline significant between SPZ Control and BS Control (p=0.050).

Similar to NK1.1 activation, we observed a modestly reduced frequency of Stat1 β/β NK cells producing IFNγ compared to their WT counterparts, although this did not reach statistical significance with the threshold set at p < 0.05 ( Figure 3F ).

However, E2F2 , ZC3HC1 , RMI1 , JAK2 , EXOC3L1 , and CSF2RB are nominally significant ( P < 0.05), also in the small non-European sample, when adjusting for lead GWAS hits ( Table 3 ).

neonatal T cells CD8 + T cells RNA-sequencing IL-12 T cell activation neonatal immunity Institut National de la Santé et de la Recherche Médicale 10.13039/501100001677 Ligue Contre le Cancer 10.13039/501100004099 Agence Nationale de la Recherche 10.13039/501100001665 Next, we analyzed the patterns of gene expression changes after TCR or TCR-IL12 stimulation, considering only highly significant differential genes (adjusted p < 0.05 and log 2 fold change ≥ 2) after TCR or TCR-IL12 stimulation ( Figure 2A ).

In GCA, there was a strong trend toward lower NK-cells in treatment-free remission compared to HCs ( p = 0.05).

From the GO based analysis, 465 nominally significant ( p < 0.05) terms were identified as enriched within the 374 genes ( Supplementary Table 2 ).

A correlation of borderline significance was found between FPW and age at biopsy ( r = 0.43; P = 0.05).

p < 0.05 was considered to indicate a significant difference, p < 0.01 an extremely significant difference, and p > 0.05 no significant difference. 3.

The lowest muscle thickness recorded in the control group was lower than that in all other dietary groups, and the difference was highly significant ( P < 0.05).

Despite this, relative abundance comparisons of individual microbes at the ASV level showed a trend towards increased abundance ( P <0.05, P FDR = 0.74; Supplementary Table 2 ) of Bacteroides vulgatus , Holdemanella biformis and Lachnospiraceae spp. in the fecal microbiome ( Supplementary Figure 2C ).

Analyses of CD8 + T cells showed a trend towards increased single IFN-γ and dual cytokine expression in the BoHV-4-M-NSP5 prime-boost group over time ( P > 0.05; Figures 3D, E ).

The significant and highly significant differences were set as P < 0.05 and P < 0.01, respectively.

The data were considered significant and highly significant for P -values <0.05 and <0.01, respectively.

Compared with the FLIPI model for OS prediction, FLIPI-SII showed improved reclassification and discrimination at 3 years (NRI = 0.245, p = 0.034; IDI = 0.013, p = 0.028), and maintained a favorable trend at 5 years (NRI = 0.247, p = 0.050; IDI = 0.018, p = 0.096).

Therefore, our nominally significant results (p < 0.05) require replication in larger, independent, and preferably longitudinal cohorts.