Excerpts

Renal disease is a major predictor of damage progression in SLE, and our findings of a near-significant association of IL-18 with organ damage in multivariable analysis ( p = 0.07) are supported by previous findings in a smaller study which reported increased serum IL-18 in SLE patients with organ damage ( 53 ).

Defined by methodology A, B, or C, higher PD-L1 group showed a better prognosis trend although the difference was marginally significant as determined by the log-rank test (p=0.07 as classified by methodology A, p=0.14 as classified by methodology B, p=0.12 as classified by methodology C, Figures 1A–C ).

The transcript levels of tnnt2 showed a trend of upregulation in GS2 compared with GS0 individuals (p=0.07).

Consistently, both antibodies elevated ADPR production in MM cells, with DARA reaching statistical significance (p = 0.03) and ISA showing a near-significant trend (p = 0.07).

As expected, a higher number of DSA had borderline significance with a higher number of HLA mismatches ( p -value = 0.07, HLA antigen data).

Of note, the expression of STAT3 in M-MDSC of CoV2+ when compared to CoV2- participants approached significance (0.4 ± 0.3 vs 15.9 ± 10.6; p=0.07).

The results for the training cohort showed marginal significance for CCR7 (p = 0.07) and significance for SPP1 (p = 0.0033), while in the testing cohort, significance was observed for CCR7 (p = 0.035) and marginal significance for SPP1 (p = 0.073) ( Figure 6F ).

ASAL showed a trend (i.e., close to statistical significance; p = 0.07; Figure 8R ) towards ctsb down-regulation, which resulted in significantly lower mRNA levels in ASAL/no lice salmon than lice-infected salmon ( Figure 8H ).

Our data support this mechanism, as patients in the MAS group had a significantly higher percentage of CD8 + T cells ( P = 0.004), and an elevated CD8 + T-cell percentage showed a strong trend toward being a risk factor for MAS in the multivariate analysis ( P = 0.0703).

There was also statistical significance found for the other three biomarkers: NEU (OR = 1.032, 95% CI: 1.005-1.059, P = 0.023), NLR (OR = 1.035, 95% CI: 0.998-1.074, P = 0.071, marginally significant), and SII (OR = 1.0001, 95% CI: 1.0000-1.0003, P = 0.041).

IL-12 was the only cytokine that showed a trend of higher PHA-induced production in controllers relative to the HCs ( P= 0.071, Figure 5E ).

In our search for correlations between microbial translocation markers, we observed a link between rDNA and LBP ( r = 0.279, p < 0.001, Figure 2J ), and an almost significant link between sCD14 and I-FABP ( r = 0.153, p = 0.071, Figure 2K ).

low expressors, only in the group of CD47 low expressors showed a trend towards the negative impact of high CD163 expression on overall survival was observed ( Figure 4H , Supplementary Figure 4A ; p=0.071 and p=0.687).

There was a statistical trend for a main effect of LPS on Ifn β 1 expression in males ( p = 0.071), but there was no interaction with IH ( p = 0.961).

Prophylactic use of rituximab showed a trend toward better overall survival both in Kaplan-Meier analysis (p=0.0717) ( Figure 1H ) and the Cox model (HR=0.66; 95%CI=0.43-1.03; p=0.0687).

Forgetfulness was near significance (OR: 2.356, 95% CI: 0.944–6.205, p =0.072).

Only procalcitonin levels showed a marginally significant correlation (r=0.173, p=0.072).

Mixed-effects logistic regression identified macular damage (p=0.027, OR = 3.70) and optic nerve atrophy (p<0.001, OR = 6.47) as significant predictors of poor visual outcomes, while complete-type BD showed a trend toward association (p=0.072, OR = 2.00).

In the low education group, only Animal Fluency approached significance (+0.99, P = 0.072), with other domains remaining nonsignificant.

Pre-booster titers in males and females are at the limits of significance: the log10 difference is -0.042 AU/ml (CI 95% -0.09; -0.00) p = 0.073, where men experience a titer increase of 10%.

Considering ORR, although close to significance, a relative change in the frequency of CD21 - B-cells was not associated with ORR in the univariable analysis (OR=0.09, 95%CI=0.01-1.25, p =0.073), but reached statistical significance in the multivariable logistic regression model (OR=0.21, 95%CI=0.00-0.71.9, p =0.032). 4 Discussion There is evidence that B-cells and TLS in the tumor microenvironment might be linked to ICI treatment response ( 14 ).

Although subtype proportions did not reach statistical significance between pSS and controls (classical P = 0.61, non-classical P = 0.61), intermediate monocytes showed an increasing trend (P = 0.073), consistent with previously reported intermediate monocyte expansion in inflammatory diseases ( 33 ).

CD169-Cre x TLR7 fl/fl mice showed a trend of reduced VSV infection in dLN as compared to Wt mice ( p = 0.0735) although the reduction was less pronounced compared to TLR7 −/− mice ( Figure 7C ).

Here, we also observed a positive trend between serum sCD14 and LBP(Spearman r = 0.21, P = 0.0735).

In the final time-to-event multivariable model (including those covariates with p < 0.1 in the univariate model), no individual parameter demonstrated an independent association with mortality, though the ASV metric approached significance (HR 1.51, 95%CI: 0.96 – 2.38, p = 0.074) ( Table 2 ) .