Excerpts

This difference is highly significant, with t -test p = 0.007 ( n = 4); the signal change observed with the control injection probably arises from mild edema due to the introduction of fluid.

The RMSD value of 0.237 was highly significant (permutation test p-value ≤ 0.0072), confirming that identical genomic sequences folded into very similar local structures despite the very different context.

Correlations between qPCR- and 16S-ASV-based MOB community proportion and CH 4 uptake were highly significant ( p < 0.008).

Despite low cDNA concentrations and low expression of the alternative TSS, we observed an overall trend in AEI in accordance with our reporter assay and cell models (median AEI = 1.06, Mann–Whitney U-test on 9 DNA ratios vs. 9 RNA ratios, p = 0.008).

Among the T cells, CD4 + (42% vs 50%, p = 0.0237) and CD8 + (25% vs 30%, p = 0.09) T cells showed a trend towards increase, while double negative (CD4-CD8-) T cells (35% vs 22%, p = 0.0082) were significantly reduced in the treatment group (Fig. 6f ). 6TdG treatment resulted in significantly reduced expression of checkpoint receptors, PD-1 and Tim3, on CD8 + T cells (PD-1: 8.2% vs 3.5%, p = 0.0097; Tim3: 6.7% vs 3.2%, p = 0.0097) (Fig. 6f ).

We also assessed eight pancreatic cancer risk loci identified in Chinese and Japanese individuals in our data and noted one nominally significant locus in the combined PanScan and PanC4 results (6p25.3, rs9502893, OR = 0.94, 95% CI 0.92–0.97, P = 0.009: Wald test; Supplementary Table 6 ).

The epithelial MCT1 and stromal MCT4 showed a trend that was negative with all the HP 13 C-MRI metabolic parameters, with a significant negative correlation observed between stromal MCT4 and k PL ( P = 0.009; Fig. 2b , Supplementary Table 3 ).

When the Marine West Coast Forest ecoregion was excluded, a strong, moderately significant correlation was present between the drainage network density (total stream + river length:total area) and the SL BA :burned area ratio ( R 2 adj = 0.66, p = 0.0091, n = 8, Supplementary Fig. 1 ).

A similar situation was encountered in APOE , where one STR (chr19:44910674) showed a change in P value from merely nominally significant ( P = 9.33E−03) to genome-wide significant ( P = 4.67E−23) (Supplementary Data 10 ) after conditioning on rs429358 (“e4-allele” in APOE ).

Interestingly, there is no correlation between RPKM FP and Kozak context (Pearson r = 0.03716, p = 0.3627), whereas Kozak context has a small but quite significant correlation with framing (Pearson r = 0.1054 p = 0.0096**).

In addition, for FI, the analyses showed multiple significant enrichment peaks in blood in men, whereas those in women were only nominally significant ( P = 0.01) (Supplementary Fig. 3a ).

Sapovirus, conversely, showed an increasing trend with an AAPC of 6.6% ( p < 0.01).

The nominally significant association signal at this lead variant (rs11934731, effect size for the minor allele = 0.029 SD, P -value = 0.01, MAF = 33%) was slightly attenuated when we performed conditional analysis with MEPE p.Lys70IlefsTer26 as a covariate in the model (effect size conditional = 0.021 SD, P -value conditional = 0.06; Supplementary Fig. 1 , Supplementary Data 1 ).

However, 4MOSC1 tumors from mice treated with anti-PD-1 showed clearly significant higher CD8 infiltration ( p < 0.01) compared with tumors from untreated mice by FACS analysis of TILs and by immune fluorescence analysis of treated tissues (Fig. 3c, d , respectively).

This compilation reveals a significant trend towards lower skeletal δ 13 C as depth increases (−1.4‰ per 5 m of depth; R = 0.68, p < 0.01).

There was a highly significant difference in cell markers among the MOL1 and MOL2 groups (all p < 0.01; Fig. 2a, b ; Supplementary Fig. 9a, b ).

The correction was done in two steps: first, we regressed the expression vector of each gene against covariates and selected those with nominally significant coefficients ( p < 0.01).

A 1.5-fold change expression cut-off for ratio experiments was applied together with anti-correlation of dye-swapped ratio profiles, rendering the microarray analysis highly significant ( P < 0.01), robust, and reproducible 48 .

Analysis of similarity (ANOSIM) between groups of nearby seas found highly significant differences (R statistic 0.561, and no pairs of groups approached this value, P < 0.01), thus re-affirming that the groups represented biogeographically distinct realms.

Both Foxo3a and 5hmC on gene bodies showed a modestly significant increase in Tet2 −/− versus WT comparing to their bindings on promoters ( P <0.01, unpaired t -test).

Based on the obtained results, the data was considered not significant (P≥0.05), significant * (P≤0.05), highly significant ** (P≤0.01), or very highly significant *** (P≤0.001).

Deletions (including frameshift deletions; hGIS1, P =0.0004; hGIS2, P =0.0038), mononucleotide repeat frameshifts (hGIS1, P <0.0001; hGIS2, P <0.0001) and splice-site mutations (hGIS1, P =0.0003; hGIS2, P =0.0002) were present at significantly increased levels in both hGIS1 and hGIS2 genes, and nonsense mutations were present at statistically significant increased levels in hGIS1 and at borderline significant levels in hGIS2 (hGIS1, P =0.01; hGIS2, P =0.0613) ( Supplementary Data 3 ).

Importantly, statistical significance or a trend toward significance was retained at other cut-points as well, including 1, 10 and 20% (PFS log-rank P =0.01, P =0.08 and P =0.03, respectively, and OS log-rank P =0.002, P =0.01 and P =0.11, respectively; Supplementary Fig. 3 ).

3b ) and a meta-analysis of the two agents revealed highly significant decreases ( P <0.01, n =25, one-sided analysis of variance (ANOVA), percentages±s.d.; statistical details in Fig. 3 legend and Methods) in the αS60:14 ratio for A30P (77.5±15.5% of WT, that is, a 22.5% decrease), E46K (61.7±10.1% of WT, a 38.3% decrease), G51D (47.8±10.0% of WT, a 52.2% decrease) and A53T (66.5±10.4% of WT, a 33.5% decrease).

The occurrence area of the subsurface-reversed MHWs showed a rising trend of 1.27 × 10 14 m 2 yr −1 over 2001–2020, followed by the deep MHW, with an increasing trend of 7.38 × 10 13 m 2 yr −1 ( p < 0.01; Fig. 6a ).