Excerpts

While five gene sets (including DNA helicase) were nominally significant (4.8 × 10 −3 ≤ P ≤2.1 × 10 −2 , Supplementary Table 5 ) these gene sets were not significant after multiple comparison correction (false discovery rate >0.10).

After additionally removing the meQTLs that were correlated with any of the five GWAS index SNPs at SLC2A9 among EA persons (Methods), cg13841979 was the only CpG with ≥4 meQTLs for MR analysis and showed nominally significant causal effects on serum urate levels ( p = 2.25E–2, Supplementary Data 10 ).

In non-BVZ treated patients ( n = 224), HRs were not significant for cluster 3 (HR = 0.72, P = 0.18, CI 0.45–1.16 for PFS and HR = 0.84, CI 0.49–1.44 for OS, Cox regression), while for cluster 2 patients, a borderline significant effect was observed for PFS (HR = 0.57, P = 2.4 × 10 −2 , CI 0.35–0.93, Cox regression), which was not confirmed at the OS level (Supplementary Figure 8 ).

While the maximal neoantigen quality is higher in those DRs without a clonal neoantigen (568.6 ± 718.1) than those with a clonal neoantigen (464.7 ± 609.2), the difference is not large in magnitude and only weakly significant ( t = 2.267, p -value = 0.024) (Supplementary Fig. 3b , right).

The analysis of a downstream target of the p38 kinase, FLNA, also showed a trend to decrease with expression of WT (10%) and a 12% reduction with mutant DLGAP4 ( p = 0.025).

While the fraction of CP glia exhibit a positive trend, only OPC numbers show a significant positive correlation with gestational age ( p = 0.026).

In PSP, we observed a nominally significant enrichment in oligodendrocyte enhancer sequences ( P = 0.027) (Fig. 1b ).

We note that MAPT is only nominally significant in the PWAS of clinical AD ( p = 0.027, FDR = 0.52), perhaps due to power limitation, and future larger GWAS may help resolve this.

LDL PRS approached significance in high LDL carriers ( β = 6.76, p = 0.028, Fig.

Despite the fact that Val-2 had a shorter follow-up period, and therefore a smaller proportion of patients experienced relapse, K-high was still highly significant (HR: 4.47; Cox P = 0.029; Supplementary Figure 8A ).

In an exploratory analysis, we did find small but significant effects in the subpopulation of neurons that received 5 Hz AM, but these were very small (median effect: ~0.2 Hz) and on the cusp of significance ( p = 0.03; Wilcoxon Sign-Rank Test).

When adjusting for clinical risk factors, 6 proteins were significantly associated with either MACE or HHF (FDR-adjusted p -value < 0.05), while for the time to DECLARE’s composite renal outcome, IGFBP6 was nominally significant ( p -value = 0.03; Fig. 4C–E ).

Among the subjects with low coffee consumption, only one association remained nominally significant (cg14476101, P = 0.03).

Look-ups in consortium data showed a nominally significant association for the leptin-decreasing allele of rs10487505 with higher BMI in the GIANT Consortium ( P =0.03, N =221,677), as well as with increased risk of early-onset obesity ( P =0.04, N =13,848) and higher birth weight ( P =0.02, N =26,836) in the EGG Consortium ( Supplementary Table 7 ).

However, neurons that encoded absolute time were more prevalent in M2, and showed a similar trend in PPC, although this did not reach statistical significance (M2: p = 0.03, PPC: p = 0.06, permutation test; Fig. 2e ).

15d ), as observed in a recent study in brain tissue 79 , which was slightly significant ( P = 0.03, ANOVA).

Instead, we find a weakly significant difference for L int for the cytological data (Fig. 4 D, p = 0.03), whereas converting cytological data from SC space to DNA space using chromosome lengths reported in ref. 55 results in significantly smaller L int for females (Fig. 4 C, p = 10 −6 ).

A highly significant ( p < 0.03) difference in PFS was found between patients with RAB5A Allred scores 7 and 8, where 7/8 patients had a PFS of 50 weeks or more, and Allred scores 0-6, where all patients had PFS less than 50 weeks (Fig. 6A ).

However, patients displayed increased dwell time in state B 4 ( t 537 = −2.8, p ≤ 0.005) and nominally significant increases in state D 4 ( t 537 = −2.13, p ≤ 0.03).

Conversely, no differences were found for FH and FHR-3 ( p > 0.05), while FHR-1 showed a nominally significant ( p = 0.03) increase in the recall setting.

The association with previous VTE for one SD increase in CFHR5 level in VEBIOS Coagulation was still nominally significant when adjusting for C3 levels (OR 1.36 [CI 1.03-1.82], p = 0.032), although weaker compared to adjusting only for age and sex (OR 1.55 [CI 1.2-2.01], p = 8.85E-04, Table 3 and Supplementary data 1 [Tab_8] ).

We observed nominally significant overlap (hypergeometric p = 0.033, Odds ratio = 1.4) between age effects on mRNA and age effects on DNAm levels at these genes.

Time post-infection showed borderline significant association with %T1-shortening in the thalamus and putamen (LMM, p = 0.034 and 0.033, respectively) (Fig. 2d ).

While patients from across all three tiers showed a trend to improved Vanderbilt scores (Supplementary Fig. 4 ), only those in Tier 1 showed a statistically significant reduction ( P < 0.035).

By stratifying patients according to the ICR/GIE classification of week 12 biopsies we found a slightly significant difference ( p value = 0.035, log-rank test) in OS and in PFS ( p value = 0.022, log-rank test) between the High-ICR/GIE and the High-ICR/Non-GIE group (Fig. 6c and Supplementary Fig 9b ).