Excerpts

Psilocin treated active responders showed a trend for less of a reduction in signal during the late response (multiple comparisons-late response-vehicle vs. psilocin; p = 0.08, Fig. 9E ).

Examination of lung fibroblasts from Col1a1-CreERT2;Fas −/− mice also revealed an increase in senescence score trending towards significance ( p = 0.08) (Fig. 7b ) and a Bcl-2 :senescence gene Pearson correlation of 29% ( p < 0.05) (Fig. 7c , Supplementary Table 7 ).

A decreasing trend with age was similarly seen for FDG BBB PS in white matter and cerebellum but associations only approached significance ( P = 0.08 and P = 0.05, respectively).

Comparison of each FEF condition relative to baseline (sham) showed that the sham condition provided a baseline between left and right FEF TUS effects, whereby left FEF TUS increased the proportion of rightward saccades ( b = −0.12, p = 0.023), and right FEF showed a trend toward more leftward saccades ( b = 0.12, p = 0.08).

Regression analysis showed that there was a marginally significant interaction between total life events and percent time spent in institutions on externalizing problems at age 16, B = 0.003, 95% CI [0.00, 0.01], β = 0.18, p = 0.08, and a significant interaction between the number of independent events and percent time in institutions on externalizing problems, B = 0.006, 95% CI [0.001, 0.01], β = 0.25, p = 0.01.

When predictive and nonpredictive events were separately compared across delay conditions, speeded RT over time for predictive actions was marginally significant ( t (23) = 1.85, p = 0.08), while slower RT over time for nonpredictive actions was not significant ( t (23) = 1.57, p = 0.13).

This association was marginally significant for caregiver report ( p = 0.08).

We repeated the analysis above using both contextual prediction error and temporal prediction error as covariates, and observed a marginally significant modulation of dlPFC/frontopolar CTD reinstatement on RT (regression coefficient: −0.0040 ± 0.0022; t 32 = −1.81; P = 0.08, one-sample t -test; d = 0.32).

Interestingly, while none of the individual genes from the signature reached statistical significance when stroma surrounding benign glands in the prostates bearing high-Gleason and low-Gleason cancers was compared (sB.high-sB.low), the difference in ssGSEA scores for this comparison was marginally significant (Fig. 4b ; t -test, P = 0.08).

Additionally, CRTAM demonstrated a downregulation, although being marginally significant after FDR correction (log2 fold change = −0.57; FDR P = 0.08).

However, we found the effect of protection on endemicity (a measure we calculated as the inverse of community-weighted mean geographic range size) was marginally nonsignificant (95% CI: −0.6 to 11.1%; χ 2 =2.99, df =1, P= 0.08; Fig. 2d ).

While the combination therapy did not reach statistical significance over chemotherapy alone, a clear trend toward improved response was observed (Cis vs Combo, p = 0.08), mirroring clinical observations in advanced NSCLC patients 85 , 86 .

Correlations between changes in caudate/putamen DAT binding and PDRP expression were of borderline significance ( p = 0.08 for both regions); those with changes in PDCP expression were not significant ( p > 0.13; Bland-Altman correlations).

The amount of overlap in the top n genes was statistically significantly higher than expected for three species pairs, and marginally non-significant ( p < 0.08) for an additional two species pairs, such that we found some evidence of non-random overlap for 5/6 species pairs (Supplementary Table 9 ).

Of the remaining three species, the increase in mortality outside the native range was nearly significant for one ( p = 0.08) and non-significant, but still apparent, for two species moved from the warmest site to cooler, wetter sites (Fig.

Within our stratified analysis by type of therapy, for anti-PD1/PD-L1 monotherapy, we observed an OR per SD of 1.25 (95% CI = 0.88−1.78, p = 0.21) for all-grade IMC, while a slightly stronger and nominally significant association was seen for severe IMC (OR per SD = 1.47, 95% CI = 0.96−2.25, p = 0.08).

Mutations in PIK3CA and MAP3K1 were significantly more likely to co-occur (after BH FDR correction) in the TAM dataset, and were near significance in MA12 although not after correction ( p = 0.08).

Spearman correlation coefficients ranged from −0.9 to −1, although with borderline significance (all P = 0.08) likely due to limited sample size.

5a ), and these participants also showed a trend towards shorter OS (median 15 versus 28 months; HR 2.0, 95% CI 0.88–4.64, P = 0.08) (Supplementary Fig. 5b ).

The same pattern of movement biases observed in single-target trials was also apparent for non-intermediate (direct) movements in dual-target trials ( μ d in the mixture model; two-way ANOVA, main effect of speed, F (1,15)=70.81, P <0.001 and a marginally significant interaction between speed and eccentricity, F(3,15)=2.30, P =0.08).

As compared to control mice given only an HFD, oral administration of spermidine significantly increased spermidine levels in WAT, with an increasing trend observed for L . reuteri ZJ617 ( P = 0.08).

The R3 subclass showed a weak trend toward NBNC (negative for HBV and HCV; 25% vs 16%; p = 0.081 by Fisher’s exact test).

While the subperiod-average percentage of the population >65 years only appeared as a marginally significant predictor (likelihood ratio test, p = 0.081) in the second-stage meta-regression (Supplementary Table 3 ), it is still conceivable that our estimates of the climate-change attributable death burden in Germany are biased by ignoring age-group-specific temperature-mortality associations.

We found a significant association between the neurochemical profiles observed for ketamine and autism in ABIDE2 ( r (14) = 0.563, p = 0.023, 95% CI [0.094, 0.828]) and a trend towards significance for ABIDE1 ( r (14) = 0.448, p = 0.081, 95% CI [−0.061, 0.772]) (Fig. 2B ).

The interaction between instruction and memory showed a trend (F(1,15) = 3.48, p = 0.082), pointing towards slightly more pronounced reaction time differences for TBR than TBF items.