Barely Significant

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In our cross-cohort meta-analysis we observe a trend towards protective associations with several cardiometabolic traits, including a nominally significant association with lower waist-to-hip ratio following adjustment for BMI—a phenotype causally linked to cardiometabolic health 47 , 48 —and a borderline significant association with reduced HbA1C levels (Supplementary Fig. 4 ), which may warrant further investigation.
We further used Jensen-Shannon divergence (JSD) scores to identify differentially deviated TF motifs across pseudotime between control and Tcf21 -KO ChromVar distributions, finding significant differences in many core TF motifs including Zeb, Klf, Runx1/2, AP-1, Srf, and Ctcf, while Tcf21 was borderline significant (padj = 0.10) (Fig. 5B ).