Barely Significant

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HFD also determined a significant increase in the weight of white adipose tissue and a significative reduction in brown adipose tissue weight, and the supplementation with CEVOO showed a trend, even if not significative, in improving these parameters, while CrOO ameliorated only the weight of the brown adipose tissue ( Figure 2 ).
For testing the intervention effect values for each outcome measure obtained from the blood samples, p -value < 0.025 was considered statistically significant, and 0.025 < p -value < 0.05 was considered to show tendency towards significance by Bonferroni’s correction for multiplicity due to the fact that two group tests were conducted at fasting (Point 1) and 2 h after ingestion of the regulated food (Point 2) on day 21, respectively.
In our study, we observed significant decreases in faecal calprotectin levels, as well as nitrogen and fat in the stools, while LDL cholesterol and vitamin A levels increased significantly, with vitamin E, albumin, and total cholesterol levels nearing significance.
Although the results were marginally significant, there exists a potential association with LMM, suggesting that the nutritional imbalance resulting from a diet characterized by a reduced intake of protein-based foods, alongside increased consumption of refined carbohydrates, high glycemic index foods, and saturated fats, may contribute to the decline in muscle health.