Analysis of the correlation between ERG and TMPRSS2:ERG expression ( Fig 3b ) revealed that there was a strong trend between the two genes (R 2 = 0.826) consistent with urinary cell and tissue data suggesting that the most common fusion (TMPRSS2 (exon 1) with ERG (exon 4)) may give rise to increased ERG expression [ 12 , 18 ].
However, the bias may be significant but not sufficiently large so, in addition, we measured the proportion of obtained essential genes with a negative Aquilles-based score in each scenario, a point where the probability of the gene being essential is higher than being non-essential.
In case of H3K9 acetylation, there was an overall increase after 72 h treatments in MDA-MB-157 cells, which was highly significant when compared to single-dose of compounds, DMSO and 48 h of treatments ( Fig 3b ).
At this condition, an interesting trend emerged with the former group presenting declines on F v / F m values, while the latter species showed higher F v / F m values.
Trends for BMI, WC, SBP, DBP, blood glucose, and HbA1c in Lao Loum females across age groups were mostly highly significant.
For example, in the mound phytolith profile in Site 1, panicoid grasses showed a decreasing trend toward the surface and in the mound phytolith profile in Site 2, they fluctuated with no clear increasing trend.
In Sites 1 and 2, although grasses of this taxon were 2–15 times more abundant on mounds than in inter-mound basins, depending on site and season, no marked difference was apparent in the representation of phytolith morphotypes characteristic of panicoids in surface soils between these two habitats in either site ( Fig 4 ).
Multivariate M gradient did not show a positive trend in the HomL M group of the Male Experiment (where large males were exposed to large females; see Fig 5A , Table 2 , S6 Fig ).
Multivariate P gradients were highly significant in all social environment manipulations except HomS F ( Table 2 ).
Nevertheless, the relationship between walking in phase coherence and motivational scores was only marginally significant.
Thus, for both types of sewage sludge, OM, CEC and SB, increased with the increase in dosage of the amendment, but K, pH and V showed a negative trend with the increase in the dosage (Figs 1 – 3 ).
The impact of treefall was, however, highly significant when using the information theory ( Table 2 ) which tested models using combinations of different variables.
However, little is known regarding the impact of converting rice ( Oryza sativa L.) to vegetable fields, an increasing trend in land-use change in southern China, on CH 4 and N 2 O fluxes.
Although the p values for memory and ALS-non-specific functions were >0.05, we noticed that it approached significance.
coli preceded by a co-directional operon, only 307 are regulated by a TF while 992 are not, a difference that is highly significant ( P ≃ 10 −7 , binomial test).
Conclusion Insomnia-, parasomnia-, and other sleep disorder-related articles showed an increasing publication trend, whereas those related to breathing-related sleep disorder showed a decreasing trend.
The JC-1 staining profile showed a significant trend whereby DHT and STS synergistically increase mitochondrial membrane permeability ( Fig 4 ), suggesting that DHT renders mitochondria more vulnerable to intrinsic apoptotic stimuli and MOMP.
Another indication was that soil salinity exhibited an increasing trend during our investigation period.
Because longitudinal developmental studies have found curvilinear developmental trajectories with age for cortical and subcortical GM volumes, with the steepest growth found in early childhood and reductions reported from (pre)adolescence onwards [ 39 – 41 ], we tested 2- and 3-way interactions with age and age 2 (i.e., Age/Age 2 xG, Age/Age 2 xE, and Age/Age 2 xGxE) which were dropped from the model when not significant or nominally significant (i.e., did not survive correction for multiple testing).
During the grape maturation, these compounds, except for protocatechuic acid, showed a decreasing trend.
PepSite2 also predicts the binding of FKBP3 to both the OLPs 438 CVICQ 442 ( Fig H60 in S1 File ) and 456 GHLMACF 462 ( Fig H37 in S1 File ) as highly significant and to 463 TCAKKLKKRNKPC 475 ( Fig H40 in S1 File ) as moderately significant ( Table F in S1 File ).
These aspects have often been observed in developing countries like Brazil [ 48 , 50 , 51 ], where the macro and micro-regional differences in relation to the hospitals are extremely significant, as well as the characteristics of the hospitalized population [ 29 , 52 ].
For parental perceived social norm and attitude towards physical activity at baseline, a trend towards significance was found.
A proportional increase in the use of self-injurious methods in self-harm was highly significant, more specifically in the use of hanging, jumping from heights and the use of other violent methods such as the use of firearms, jumping before a moving object or other traffic related injury.
For example, in 1995, we demonstrated a near-significant effect of home visits by a community nurse in case of non-compliance with referral to outpatient aftercare among self-harm patients after discharge from the A&E departments involved in the current study, on repetition of self-harm [ 34 ].