Excerpts

The MSA of chemicals indicated a highly significant difference of the mean MSA of mTOR inhibitors and non-inhibitors as shown by the p value of 1.14×10 −18 ( Figure 2 ).

A pattern of results for time delays (while approaching significance) is consistent with the ‘reflective rationality hypothesis’.

Although the citric acid response pattern and the maximum Ca +2 influx response observed in these three cell types are different, the responsiveness to citric acid stimulus in the form of increased Ca +2 influx was a clear trend displayed by these TRPA1 expressing cell types, unlike the lack of any significant response seen with the hTRPV1 expressing CHO cell line (data not shown).

This association was nominally significant in white participants ( P -value nom = 0.004), but did not remain significant after correction for multiple testing ( Table 2 ).

Thus, when leptin levels are adjusted for percentage body fat, the association between rs1943225 and higher leptin levels was observed to be highly significant in white females ( Table 3 ).

And there was a significant trend in risk with increasing number of meals cooked by deep frying.

However, after indexation to BSA, this difference disappeared in our as well other studies [29] , although one study showed a trend toward higher LVDD/BSA values in women compared with men [28] .

The association between ‘number of paired teeth’ and height showed a positive trend across quintiles in males, whereas no relationship was evident in females ( Figure 1a and 1b respectively).

Water column TDOC was closely correlated with water column TDN (r = 0.92, p < 2.2e-16; Figure 2 ), while water column TDP exhibited a much weaker relationship with TDOC (r = 0.27, p = 8.0e-11; Figure 2 ).TDOC did not exhibit a strong trend across the season ( Figure S2 ).

Highly significant increases (over 1000-fold) in IL-8 and IL-6 transcripts and significant increases in TNF (2-fold) in HD patient post-mortem striatal tissue have been reported in independent studies [10] .

Table S4 Permutation analysis of the association matrix shown in Table S2 to find out if species with shared family and fruit types show more or less significant associations than expected by random distribution of significant cases over all pairs of species. n t : total number of significant associations of specified type; m t : total number of pairs with shared family or fruit type; n s : number of pairs with shared family or fruit type which show a significant association; n s exp : expectation of n s under 10,000 randomization of significant cases over all pairs of species.

For mortality, we observe borderline significant risk for males.

While the late effect turned out to be more relevant for the goodness of fit, inclusion of the earlier, temporary protective effect was also highly significant for females.

A linear mixed model with sex as a factor indicated that GBW did not differentially change with breeding stage in either sex for breeding stages ≤ 0, although the sex by breeding stage effects was marginally non-significant ( Table 1 ).

There was remarkable functional uniformity among the most highly significant annotation terms for this group of 98 genes.

The linear effect of MS was highly significant; this model suggests that there is an important association of MS with the serum UA concentration.

This effect was probably due to higher delta values for stimulation of the front legs compared that of the antennae, although the posthoc comparison was only near-significant due to multiple comparison correction (Tukey HSD test, p = 0.047>α corr = 0.025).

Importantly, because several previous reports suggest that there may be significant gender differences in the natural history of COPD [8] – [10] and some experimental observations show that the leukocyte transcriptional response to other acute stressors (infection) is different in males and females [11] , we recruited participants stratified by sex.

6 ) and this value was approaching significance.

NFΚB (p50/p105) in the lungs of BL treated septic mice showed only a decreasing trend.

Here, in an unbiased sample of publicly available microarray data on gene expression in various knockouts, highly significant differences from wild-type (either increases or decreases) are noted in the gene expression coefficients of variation (CVs) of virtually every knockout considered.

A p-value of less than 0.05 and 0.001 were considered to be statistically significant and highly significant, respectively.

Hemizygous male Cdkl5 knockout mice showed a significant decrease in the number of head tracks performed in the test compared to wild-type littermates while homozygous female knockouts showed a trend for reduced head tracking ( Figure 2E ).

Gene ontology (GO) terms of the GO ‘biological process’ featured highly significant enrichment in the terms ‘mRNA processing’ and ‘translation’, after both SCNT and fertilization (FDR, q<0.01 with Benjamini-Hochberg correction for multiple comparisons, Table S1 ).

The strobilation curve suggests that there may be significant strobilation beyond early June, as observed in occasional plankton sampling in the area ( Fig.