“did not reach statistical significance”

2 E), the positive associations did not reach statistical significance but showed a suggestive trend.

In contrast, among patients who received mastectomy or conventional fractionation, proton therapy showed a trend toward lower rate of radiographic pneumonitis; however, the difference did not reach statistical significance.

[ 5 ] (double-blinded RCT) included patients with severe COVID-19 and showed a trend towards faster time to clinical improvement that did not reach statistical significance; however because this trial was stopped early (due to the decline in new cases in China), it may have been underpowered to detect an effect.

There was also a strong trend for putatively tolerant children to be more susceptible to malaria compared to the exposed sensitized children, although this relationship did not reach statistical significance.

Serum decorin levels showed an increasing trend with advancing CKD stage; however, these differences did not reach statistical significance and were not correlated with renal function parameters.

The levels of 5-HIAA in serum, medulla oblongata, and ileum of rats treated with cisplatin had an increasing trend, but did not reach statistical significance ( Figure 5A – C ).

2I ), with an observed trend toward increased LK fraction and LSK cells that did not reach statistical significance (Supplementary Fig. 2H ).

There is an apparent trend towards less cell damage as measured by lactate dehydrogenase release in BAL of CDK inhibitor-treated mice but this did not reach statistical significance ( Figure 7e ).

The association between high PIV and deeper myometrial invasion (≥ 50%) showed a trend but did not reach statistical significance ( P = 0.078).

In addition, the difference in change from baseline between the groups (Extended Data Table 1a ) showed a trend toward a reduction in arterial inflammation in the low-dose IL-2 group compared to placebo, but did not reach statistical significance (−0.103, 95% CI −0.22 to 0.02, P = 0.086).

In the SMG versus NG comparison, the KEGG oxidative phosphorylation pathway (mmu00190) also showed enrichment (NES = 1.56, p = 0.003), though this did not reach statistical significance after FDR correction (FDR = 0.468), suggesting a possible trend toward increased oxidative metabolism.

In contrast, the Shannon diversity index exhibited a decreasing trend in the F group, although this change did not reach statistical significance ( p > 0.05).

Most genes in the Esx-1 loci that did not reach statistical significance showed a trend towards an increase in the number of transposon insertions (Fig. 2a , Supplementary Fig. 3a , Supplementary Data 1 ).

Though there was a positive trend with increasing cell loss and increased respiratory chain deficiency in remaining cells, this did not reach statistical significance (Spearman's rank correlation coefficient).

In WT mice injected with LpX ( Fig 5A ), a small trend toward increasing UACR values was observed but did not reach statistical significance ( P = 0.106, One Way ANOVA).

The post hoc analysis indicated that the LE group demonstrated significantly elevated Sirt1 expression compared to the HE group ( Figure 8 A, p < 0.001) and showed a trend toward elevated expression relative to the CE group, though this difference did not reach statistical significance ( Figure 8 A, p = 0.069).

Although Asian studies showed a trend toward greater improvement in imaging outcomes, this difference did not reach statistical significance when formally tested for interaction ( p for interaction = 0.9201 for MACE and 0.0581 for LLL), suggesting that the overall treatment effect of DCB was largely consistent across populations despite baseline risk factor disparities.

On the other hand, binding of rEgAgB8/2 to macrophages was not observed; the binding index showed a trend to increase in a dose dependent manner, but this trend did not reach statistical significance (Fig. 4a ).

Compared with software-assisted interventions, AI-assisted interventions exhibited a positive trend (SMD = 0.15, 95% CI: −0.68–0.99), though this difference did not reach statistical significance, as presented in Figure 5 D.

Specifically, Dunn’s multiple comparisons test indicated that while the height loss score in the Severe group (2.700 ± 0) was numerically higher than that of the Mild group (1.667 ± 0.471), this pairwise comparison showed a strong trend but did not reach statistical significance (adjusted p = 0.0988), likely due to the conservative nature of the non-parametric test and the limited sample size in the Mild cohort.

Among sirtuin family members, SIRT1, SIRT3, and SIRT4 exhibited >2-fold induction (log 2 FC ≈ 1.0–1.3), whereas SIRT5 showed a positive trend that did not reach statistical significance, likely due to low read counts and partial RNA degradation in irradiated samples.

Although it did not reach statistical significance, an apparent trend toward decreased UPEC burden in bladder of acidotic HeJ mice likely resulted from increased diuresis caused by ammonium chloride supplementation of the rodent diet (dark cycle urine volume [ml/mouse per day]: 2% NH 4 Cl diet = 1.5 ± 0.2,; p < .05 versus normal rodent diet = 0.80, Table 2 ).

Notably, the low-dose rhCol III group (5 μg/mL) showed a trend toward reduced ROS fluorescence but did not reach statistical significance ( p = 0.0554), which may reflect a smaller effect size at low exposure, limited statistical power, and the known methodological limitations and sensitivity of commonly used fluorescent probes ( 68 , 69 ).

Although these differences in ORR did not reach statistical significance (Chi-square p = 0.08, likely due to limited power), a numerical trend is evident.

Furthermore, elevated PCT showed a trend towards shortened survival but did not reach statistical significance ( p = 0.053 , HR: 1.01 / 95% CI 1.00–1.03) (Table 2 ).