“nominally significant”

, Science and Technology (MEXT) of Japan Institute for Comprehensive Medical Science Fujita Health University (Joint Usage/Research Center for Genes, Brain and Behavior accredited by MEXT) in Japan Decreased locomotor activity in BARP KO mice In the light/dark transition test, BARP KO mice showed a nominally significant decrease in total distance traveled in the light and dark chambers, and number of transitions compared with WT mice [genotype effect, F (1, 42) = 4.945, p = 0.0316; genotype × time effect, F (1, 42) = 0.100, p = 0.7536 and t = 2.939, df = 42, p = 0.0053, respectively] (Figures 2A,C ).

Interestingly, one suggestive signal for tau‐PET on Chr7 ( CRYGN,RHEB /rs12538040, MAF = 0.196, P = 3.80E‐07, β = −0.84) was also nominally significant with the same direction for p‐tau217 ( P = 0.032, β = −0.21). 3.4 Mult‐trait GWAS Multi‐trait GWAS was performed on a subset of 76 participants from ABC‐DS with all four tau biomarker measurements available, aiming to identify pleiotropic loci that simultaneously contribute to all tau biomarkers.

1.7%), with a nominally significant adjusted OR of 16.62 (95% CI 1.27–217.22; P = 0.032), though this estimate is imprecise due to sparse events and should be interpreted with caution.

Dietary pattern showed nominally significant associations with barriers related to taste and texture, meal preparation knowledge, and preparation time (all p ≤ 0.032); none survived Benjamini-Hochberg correction across 12 simultaneous tests (false discovery rate-adjusted p ≥ 0.062).

Similarly, leveraging a depression GWAS that includes up to 1,999,601 EUR individuals ( 26 ), depression showed only a nominally significant genetic correlation with GlycA ( r g = 0.138, SE = 0.064, p = .032), with an estimate that was about half of the one observed for PTSD.

For leaf C:N, although the global Elevation smooth was nominally significant ( p = 0.032; see Figure 2h and Table 2 ; Table S5 ), the term was effectively shrunk to zero (edf ≈ 0), indicating a negligible elevational effect on leaf C:N across species.

RGS4 was significantly expressed in the coronary artery tissue according to GTEx data (median transcripts per million =18.23), although rs10799925, an intergenic lead variant, and RGS4 expression showed only nominally significant eQTL association (normalized effect size =−0.150; p =0.032).

Prior to multiple-testing correction, a single locus—D12S391—returned a nominally significant p -value ( p = 0.0320).

There is a nominally significant rs11854251‐ LINC00923 association in the spinal cord (cervical c‐1) ( p = 0.032).

meta-analysis ( 29 ), only ARRDC3 passed a Bonferroni-corrected P value threshold ( P = 0.00035), while WSCD1 was nominally significant ( P = 0.032); one of the Falconnier et al. genes had been filtered out during quality control processing in Carter et al.

When women with early menopause were added, breast cancer risk remained increased and ovarian cancer was also nominally significant (3.38 [1.15, 8.65]; p=0.032).

The association with previous VTE for one SD increase in CFHR5 level in VEBIOS Coagulation was still nominally significant when adjusting for C3 levels (OR 1.36 [CI 1.03-1.82], p = 0.032), although weaker compared to adjusting only for age and sex (OR 1.55 [CI 1.2-2.01], p = 8.85E-04, Table 3 and Supplementary data 1 [Tab_8] ).

11 We only found a nominally significant association of rs10191329 with the yearly change rate of the lateral ventricles ( p = 0.032), but not with any of the other 14 investigated metrics, including yearly change rates of the total brain volume ( p = 0.690), thalamus ( p = 0.953), or putamen ( p = 0.613).

38.9%), with a nominally significant difference in the remission rate (p = 0.032) but not in the response rate (p = 0.28).

Supplementary data thorax-2023-220856supp002.xlsx Causal estimate for seropositive RA on IPF The primary IVW-FE analysis gave a nominally significant result for a protective causal effect of seropositive RA on IPF (OR 0.93; 95% CI 0.87 to 0.99; p=0.032) ( figure 2A and online supplemental table 6A ).

GlycanAge was significantly lower in the active group compared to the inactive group (β = -7.437, p.adj = 7.85E-03), and nominally significant and increased in professional athletes compared to the active group (β = 7.546, p = 3.20E-02).

Comparing MDD-SI and MDD-nSI, nominally significant group × time interactions were observed for the λ ( F = 4.530, p = 0.033; β = 0.725, 95% CI: 0.049 to 1.400), and nodal efficiency exhibited a nominally significant group × time interaction in the right posterior cingulate gyrus ( F = 3.958, p = 0.046; β = -0.783, 95% CI: -1.565 to -0.003).

The results showed the same trend for increased right-hand skill in carriers of the minor allele; the association was nominally significant with rs11855415 ( P = 0.033, β = 0.19, Table 1 ), but did not meet significance for rs9806256.

Pre-gestational DM showed a nominally significant inverse association (OR 0.32; 95% CI 0.11–0.91; p = 0.033); however, this result should be interpreted with caution given the very small number of pre-gestational DM cases ( n = 22 total).

In contrast, cognitive function demonstrated a nominally significant moderating effect ( p = 0.033, adjusted R2= 33.09%; Fig. 3 D).

Analysis of the allelic distribution among patients according to their asthma severity also indicated nominally significant associations of allele A of IL-4Rα A1199>C, allele T of IL-4Rα T1570>C and allele A of TNFα TNFα C-863>A with asthma severity (p = 0.033, p = 0.018 and p = 0.047, respectively).

A nominally significant ROC curve (p = .033) was obtained for this combination (Figure 1 ).

Moreover, we found nominally significant effects (uncorrected) of PAE for FA in the ICP-R (p = 0.033) and SS-L (p = 0.021).

rs3785883-A allele was also nominally significantly associated with LOAD risk (OR = 1.06, 95% CI = 1.01-1.13, p = 0.034).

This specific observation reached a nominally significant association (r=-0.19; p=0.034; table 3 ).