“nominally significant”

In exploratory analyses, treatment with vericiguat resulted in flow-mediated dilation mean difference of 0.7%, (95% confidence interval: −1.1% to 2.5%, p = 0.40) and a nominally significant reduction of log NTproBNP of −0.42 (95% confidence interval: −0.81 to −0.04, p = 0.03).

SNPs that remained nominally significant (p = 0.03) and therefore contributed to explaining additional THP variance after adjusting for rs12917707 were rs115312009, rs147825435, rs76619864, and rs75432530.

However, multiple known associations with TSH levels in European ancestry were nominally significant in African Americans, including PDE8B (rs2046045 p = 0.03, β = −0.09), VEGFA (rs11755845 p = 0.01, β = −0.13), and NFIA (rs334699 p = 1.50×10 −3 , β = −0.17).

These associations were also identified as nominally significant in CTRP, whereby GO process “Growth” is associated with PC2 ( P = 0.03) and “Regulation of Apoptosis” is associated with PC3 ( P = 0.01) and PC5 ( P = 0.01).

We also found nominally significant discrimination of unaffected siblings from healthy controls based on successful stop activation maps (AUC = 0.59, p < 0.030, 95% Modified Wald CI: 0.52–0.66 AUC) as well as nominally significant discrimination between participants with ADHD and healthy controls based on failed stop activation maps (AUC = 0.60, p < 0.019, 95% Modified Wald CI: 0.54–0.66 AUC, Fig. 1 ; for balanced accuracy, sensitivity and specificity measures in the complete and matched sample see Supplementary Table 2 ).

There was a nominally significant excess of heart failure (HR 1.34, 95% CI:1.03 to 1.75, p=0.03) but no associations with other studied cardiac outcomes.

When controlling for CAG size using the adjustment method, we found a significantly reduced expansion frequency in Htt Q175neo+ (two-proportion z -test, P < 0.01), while the effect was only nominally significant when adjusting through the modeling methodology (two-proportion z -test, P = 0.03; Bonferroni corrected significance threshold P = 0.0167), likely due to the reduced sample size enforced by this methodology ( Figure 7D and Table S3 ).

However, among the 116 EpiScores, only CXCL10 showed a nominally significant difference ( p = 0.03 95% CI: 0.001–0.0188; Figure 1 ), but this did not remain significant after FDR adjustment, highlighting the uncertainty of small effect sizes. 3.5.

Although 2-component systems did not reach the FDR 0.1 threshold in DINE-CD, it was nominally significant at P = .03.

While a nominally significant association of higher PGS with lower CSF Aβ 42/40 was observed ( n = 169, uncorrected p = 0.03), the only other biomarker to show a significant association was SNAP‐25.

The treatment effect for 360 mg, every 2 weeks vs placebo was nominally significant (−16.3%; nominal P = .03); however, significance could not be claimed because the hierarchical testing sequence was interrupted.

Look-ups in consortium data showed a nominally significant association for the leptin-decreasing allele of rs10487505 with higher BMI in the GIANT Consortium ( P =0.03, N =221,677), as well as with increased risk of early-onset obesity ( P =0.04, N =13,848) and higher birth weight ( P =0.02, N =26,836) in the EGG Consortium ( Supplementary Table 7 ).

The nominally significant correlation between ΔFA genu and reaction time (ΔRT) ( p = 0.03) may support this notion.

The CLDN3 variant was nominally significantly associated with dyslexia when comparing the discovery and RD cases with either the TD cohort ( P = 0.03) or the general population (i.e. gnomAD data; P = 0.003) (Supplementary Table 17 ).

We also observed higher insulin levels in LoF heterozygotes and homozygotes in the first 30 min of the test (β=0.59, p =2.6×10 –3 ) and a nominally significant trend toward elevated insulin levels throughout (β=0.34, p =0.03).

When comparing within-panel profile distances between the G2–G3 group and G1, no clear separation of group centroids was observed for the primary Aitchison metric (CLR-Euclidean) (PERMANOVA: p=0.094; R2=0.009), whereas Bray–Curtis distances showed a nominally significant difference with a small effect size (PERMANOVA: p=0.030; R2=0.022).

In the sub-elite, the recessive model was nominally significant ( p = 0.03), but it did not survive FDR (FDR-adjusted p = 0.09).

When adjusting for clinical risk factors, 6 proteins were significantly associated with either MACE or HHF (FDR-adjusted p -value < 0.05), while for the time to DECLARE’s composite renal outcome, IGFBP6 was nominally significant ( p -value = 0.03; Fig. 4C–E ).

Out of 56 SNPs analyzed, one SNP in the ESR1 gene (rs2982712) was nominally significantly associated with PND (OR 0.83, 95% CI 0.71–0.98, p = 0.03) as well as with persistent depression (OR 0.77, 95% CI 0.61–0.98, p = 0.03) in the overdominant model (DD/dd vs.

A further nominally significant difference was observed for case 8 (p=0.031), which did not survive Bonferroni correction.

Similarly, ΔL3 was significantly increased when focusing on measurements deriving from the 800-g implants ( p = 2.98 × 10 –5 , Bonferroni adjusted p = 0.0002); whereas the Δ increase observed for 400-g implants was nominally significant, it did not pass multiple testing correction ( p = 0.031, Bonferroni adjusted p = 0.188).

A nominally significant difference was observed for bevacizumab at the 12-month landmark, favoring grade 2 over grade 3 (68.3% vs. 37.2%, p = 0.031); however, this isolated finding was not supported by a significant global log-rank comparison across grades ( p = 0.09) and was not consistently observed at other landmarks.

Also an inverse relationship between milk and milk product SFA and the proportion of EPA was nominally significant after adjustments (for log-transformed: β = −0.069, P = 0.031).

We have found nominally significant associations with total dairy and milk in every population [BPRHS (P = 0.031 for dairy and P = 0.037 for milk), GOLDN (P = (2.8 × 10 −3 ) for dairy and P = 1.1 × 10 −3 for milk), PREDIMED (P = 1.9 × 10 −6 for dairy and P = 4.0 × 10 −6 for milk) and WHI (P = 3.4 × 10 −66 for dairy and P = 1.2 × 10 −65 for milk] despite differences in allele frequency and amount of milk consumed.

Among all methods and metabolites, only the weighted median estimate for GCST90277281 indicated a nominally significant association (OR = 0.93, 95% CI: 0.87–0.99, P = .031), suggesting a possible weak inverse effect.