Cluster heatmaps ( Figure 7 F) and species composition analyses ( Figure 7 G) supported these observations: compared to the Mod group, the SI-treated group showed a trend toward decreased abundance of potentially harmful genera (e.g., Mucispirillum, a genus associated with chronic inflammation [ 44 ]) and increased abundance of beneficial taxa, including short-chain fatty acid (SCFA)-producing Akkermansia [ 45 ].
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The sildenafil-treated group showed a trend toward lower HIF-1α immunoreactivity compared to the contrast media group, with a medium effect size (Cohen’s d = 0.71), though this difference did not reach statistical significance after correction for multiple comparisons (Dunn’s test, p = 0.050).
Volatile acidity (expressed as acetic acid) showed a trend of first decreasing and then increasing, reaching its highest value (0.53 g/L) at 5 days and its lowest value (0.38 g/L) at 9 days.
In our study, ANGPT1 expression showed a trend toward higher levels in infertile patients, while ANGPT2 was relatively higher in donors.
Fibrosis-related variables, including elastography-defined fibrosis stage ≥ F2 and higher FIB-4 categories, showed a trend toward discordance; however, these associations did not reach statistical significance ( p = 0.055 and p = 0.09, respectively) ( Table 3 ).
In contrast, patients with PE exhibited significantly higher methylation levels in T compared with D tissues ( p = 0.035), while A tissues showed a trend toward higher methylation compared with D tissues, although this difference did not reach statistical significance ( p = 0.052).
Although no significant association was found between the response criteria and progression ( p > 0.05), functional imaging showed a trend toward better correlation with longer progression-free survival.
Although droplet size increased slightly after 30 d, it still showed a trend of first increasing and then decreasing with the concentration of XG.
Taken together, STEMI patients showed a trend toward lower FGF23 levels 3 h after reperfusion, consistent with the decline phase observed in the TASH cohort at the 2–4 h window. 4.
The two groups showed similar reductions in negative emotional experience during emotion regulation, whereas individuals with habitual exercise showed a trend toward lower right dorsolateral prefrontal cortex (rDLPFC) activation during expressive suppression.
Analysis of microglial polarization markers revealed that the M1-associated protein CD14 showed a trend toward an increase in I S without reaching statistical significance, whereas the M2 marker Arg1 was reduced.
While VEN treatment significantly reduced, or showed a trend toward reducing, the colony number and size of PAR cells, both the VENM and VENK cells showed minimal changes in colony number and size, indicating reduced sensitivity ( Figure 1 E,F).
For instance, patients on an SERD (fulvestrant) showed a higher hazard ratio (HR = 2.302, p = 0.0678), and those with non-visceral metastases (HR = 2.008, p = 0.0696) also showed a trend toward poorer outcomes without statistical significance. 3.4.
Although the four groups were comparable in terms of age, the sex distribution showed a trend-level difference between the ADHD and ED groups, which did not survive correction for multiple comparisons.
iTRPC6GoF showed a trend towards an increase in Ca 2+ influx in comparison to TRPC6-WT but with very large variability.
CCNA2 mRNA levels showed a trend towards association with OS, but the result did not reach statistical significance (AUC =0.63, 95% CI: 0.35–0.91, p= 0.36, Figure 3E ).
The charge transfer of inhibitory synaptic events showed a trend toward increasing from P17 to young adulthood; however, it was not statistically significant across age groups (P17: 38.06 ± 3.55 pC; P35: 38.10 ± 2.66 pC; P56: 45.51 ± 4.60 pC; F (2,49) = 1.351, p = 0.2686, one-way ANOVA).
The values indicate that both in the pooled data and the stratified analysis by sample state, frozen mussels showed a trend toward slightly higher efficiency (up to 99.91%) compared to lyophilized ones.
Similarly, the Chao1 richness index showed a trend toward reduced richness in the osteoporotic group but it was not statistically significant (mean: 368 ± 27 vs. 391 ± 30; p = 0.067).
Meanwhile, with the increase in first 24-hour BUN values, mortality risk generally showed a trend of first increasing and then rapidly decreasing, potentially reflecting that at extreme values, patients entered a late stage of renal failure where risk was driven by multisystem dysfunction rather than isolated BUN elevation.
Additionally, only the CD14 − CD16 + monocyte subset showed a trend toward increased frequency under IR conditions, which was reversed by colchicine treatment ( Figures 2A, B ).
The mitochondrial number normalized to cytoplasmic area showed a trend toward reduction (~0.7-fold), although this change was not statistically significant ( Fig. 4O ).
Semi-quantitative analysis showed a trend toward increased AT1R expression in ECRS NP compared to non-ECRS NP.
Although not statistically significant, MPA patients showed a trend towards an increased risk of thromboembolic events (pulmonary embolism: HR 1.16, 95% CI 1.01 -1.33; deep vein thrombosis: HR 1.17, 95% CI 1.03-1.32) and the risk of heart failure compared to GPA (HR 1.15, 95% 1.03-1.27) ( Figure 3 ).
His laboratory parameters showed a trend improvement towards normalization.