Furthermore, patients in group A showed a trend to lower PD-L1 TPS values ( p = 0.042–0.452 for various cut-off values, Table 1 ), which was also associated with poorer response to ICI therapy in the current (Supplementary Table 1) and previous studies [ 30 ].
PCoA analysis of the bacterial community showed a trend toward separation based on ripening stage, although with substantial overlap among groups (R = 0.2153, P = 0.043).
Moreover, 3D LV radial strain showed a trend toward reduction in the obese group (36.1 ± 5.2% vs. 38.6 ± 4.1%, p = 0.043), though this does not survive correction for multiple comparisons and should be interpreted cautiously.
When grouping cases with mTLS and/or LA together in PTs or pMets, positive cases showed a trend, not reaching statistical significance, toward longer OS but not PFS in pMets (Log rank p = 0.043 and 0.34).
This showed a trend towards improved survival for patients with baseline sSema4D < 41.74 ng/mL (log-rank 4.045, p = 0.044; Figure 3 B).
Although we did not observe a 3‐way interaction of group × condition × response ( F (3,105) = 2.041, p = 0.113, partial η 2 = 0.055), we observed that irrespective of the stimulus condition the low perceivers showed a trend towards increased confidence in reporting the absence of the target compared to the high perceivers (significant group × response: F (1,35) = 4.382, p = 0.044 partial η 2 = 0.111, with post hoc pairwise comparisons yes: F (1,35) = 0.698, p = 0.409, partial η 2 = 0.020; no: F (1,35) = 2.696, p = 0.110, partial η 2 = 0.072) (Figure 3E ).
Positive surgical margin rates showed a trend toward improvement over time ( χ 2 = 12.9, df = 6, p = 0.044).
At 10 mo, Rer1 showed a trend towards a significantly reduced expression in 5XFAD female mice (Fig. 5 K) (Genotype: F(1,10) = 5.315, p = 0.044; RGs: F(2,20) = 0.402, p = 0.674; Genotype*RGs: F(2,20) = 0.537, p = 0.593).
Divergence emerged over time: at 4 and 5 months the tUS– group showed a trend toward lower DI values compared to tUS+ (p = 0.044 and p = 0.017 uncorrected; Bonferroni-adjusted p = 0.265 and p = 0.101, respectively).
In the stationary pattern condition, post hoc analysis showed a trend toward an increased PPD ratio [uncorrected p = 0.044; corrected p = 0.088], whereas no significant difference was observed in the moving pattern condition (uncorrected p = 0.230; corrected p = 0.460) (Fig. 3 B).
Analyses on specific metabolizer phenotypes showed a trend for higher frequency of CYP2D6 ultrarapid metabolizers (UMs) in remitters compared with non-remitters in patients with TRD (χ 2 = 4.76, p = 0.045), but not in patients without TRD (χ 2 = 0.02, p = 1.00, Supplementary Table S9 ).
And the 12-month DoR rate in OG and CG was 50.0% (95% CI: 27.1–69.2%) and 22.2% (95% CI: 3.4–51.3%), which showed a trend toward marginal statistical significance ( χ 2 =4.034, P =0.045).
Further analysis showed a trend towards a higher utilization of non-excisional techniques in males ( p = 0.045) and a significant association between co-morbidities and the use of excisional techniques ( p = 0.049) (Table 1 ).
However, we did not observe a significant prognostic impact of HR FISH as defined by the R2‐ISS classification in NDMM patients, and in RRMM, HR FISH showed a trend toward shorter PFS (median: 6.5 vs. 11.6 months, p = 0.045) and OS (median: 19.7 months vs. not reached, p = 0.11) (Supporting Information S1: Figure S2 ).
In contrast, patients with a dilated left atrium (LAVi ≥ 40 mL/m 2 ) showed a trend toward worse outcomes with propafenone, including higher 1-month mortality (HR 3.6, p = 0.045) and slower cardioversion (median 18 h vs. 6.4 h with amiodarone, p = 0.05) ( 56 ).
Gender showed a trend toward better OS for females, reaching significance for PnI patients (HR 0.75, p = 0.045), but not for LVI individuals (HR 0.80, p = 0.12).
This analysis revealed that learning-related changes in MT showed a trend toward significant correlation with changes in beta ERD in P-SMC ( β = 0.036, p = 0.045; with all conditions included, β = 0.030, p = 0.089; Fig.
Notably, COL9A2 , a chondrogenic cough-associated gene, showed a trend toward downregulation across both comparisons (log 2 FC = −0.65, P = 0.0456; log 2 FC = −0.69, P = 0.0175), suggesting a potential role in structural changes to the extracellular matrix contributing to chronic cough through altered airway mechanics or fibrosis.
Upper limb tremor severity showed a trend toward higher action tremor in ET-ns ( p = 0.046, rank-biserial correlation = 0.428), but this difference did not survive correction for multiple comparisons ( p_adj (FDR) = 0.098).
Attachment avoidance (AVD) did not significantly modulate theta during Reappraise (ps ≥ 0.19), but showed a trend toward increased theta during Suppress in the mPFC bilaterally (L mPFC: β = 0.139, SE = 0.069, t = 2.00, p = 0.046; R mPFC: β = 0.140, SE = 0.069, t = 2.01, p = 0.045).
However, although HbA1c showed a trend toward significance ( P = 0.046), but did not meet the Bonferroni-adjusted threshold ( P > 0.025).
Patients treated with cangrelor showed a trend toward higher odds of achieving a discharge with a mRS 0 to 2 (40% versus 26.7%; OR, 2.42 [95% CI, 1–5.78]; P =0.046).
The association between GCTTC haplotype non-carriers and advanced tumor size showed a trend towards significance (OR = 0.380, 95% CI: 0.166–0.869, p = 0.046).
2 . Discussion In our study, the high-dose group (0.5–0.9 μg/kg/h) showed a trend of relatively weaker neuroprotective effect compared to the low-dose group (0.1–0.5 μg/kg/h) on postoperative Day 2 ( p = 0.046).
Conversely, at a dosage of 21 (range, 20–22) mg/kg/day, the posaconazole concentration showed a trend toward significantly lower concentrations compared to the dosage of 18 (range, 17–19) mg/kg/day (P=0.046, Table 2 ).