unsolved HRD cases showed borderline non-significant enrichment for rs118031911/T in unsolved cases ( p -value = 0.07, OR = 2.30, CI = 0.94–6.76, by Fisher’s exact test), possibly indicating that either well-defined triallelism does not take place for this variant or that we did not have enough power to detect it.
3c ) with one additional gene, NIPAL3 , marginally significant ( P = 0.07 by case-control analysis) (Fig. 3c ).
After adjusting for sex, this association remained nominally significant (HR = 4.48 [0.90–22.23], p = 0.07), consistent with our findings showing MS3 as at higher risk of MI (Fig. 4D ).
Below 4100 m, E SMR demonstrated an increasing trend with elevation (approaching statistical significance, P = 0.07), whereas above this threshold, E SMR remained relatively stable with minimal and statistically insignificant variation.
For PDX, there was no significant correlation of success with these three variables, but viable cell count showed near significance ( p = 0.07).
This trend reached near significance ( P = 0.07, exact Wilcoxon test) in groups administered with CH505 sequential gp120 Envs when they were formulated in AS01E ( N = 8), with mean autologous tier 1 (CH505.w4.3)-neutralizing antibody ID50-titers of 2264 ± 2932, relative to those administered with CH505 TF Env gp120 alone formulated in AS01E ( N = 8), which by comparison, induced mean autologous tier 1 (CH505.w4.3)-neutralizing antibody ID50-titers of 630 ± 383.
Consistent with our original report, there was a favorable trend to improved OS with melanoma cognate help (HR 0.64, 95% CI: 0.40–1.04, P = 0.07, Addendum Figure 1A; original report: HR 0.65, 95% CI: 0.40–1.05, P = 0.08), with delayed separation of the curves starting at 2.5 years and progressive widening of the curves such that the OS estimate for the 12MP + 6MHP regimen exceeded the upper bound of the 95% CI of the OS estimate for the 12MP+tet regimen at 8 years (Addendum Figure 1B).
When we excluded the probands with high impact variants (i.e., deletions or LoFs impacting LoF intolerant genes or missense variants with the missense badness, PolyPhen-2, and constraint 28 (MPC) score > 2) in 183 ASD genes 26 , those with dysmorphic ASD still had higher average GRVSs than those with nondysmorphic ASD with a trend toward significance ( P = 0.07, one-sided Wilcoxon rank-sum test).
In contrast, there were significant correlations between histological abnormalities in the large intestine and reduced infant macaque growth kinetics including the cecum ( P = 0.02), ascending colon ( P = 0.02), transverse colon ( P = 0.03), descending colon ( P = 0.07; trending towards significance), rectum ( P = 0.004), and the large intestine in total ( P = 0.01) 20 .
Interestingly, 4-months-old Fus ΔNLS/+ mice showed a trend towards longer interaction with the intruder mouse as compared with Fus +/+ mice ( p = 0.07) (Fig. 2a ), that was significant at 10 months of age (Fig. 2b ) and persisted until 22 months of age (Fig. 2c ).
Compared with control treated mice, the anti-CD20/B220 Ab-treated 3×TgAD showed a trend toward increased activity in the OFA ( p = 0.07, 30 min, n = 5, Supplementary Fig. 5B ).
forgotten: t (17) = 2.48, P = 0.02, CI: [−0.14–(−0.01)], Cohen’s d = 0.58; approaching significance for n-PK pairs, remembered vs. forgotten: t (17) = 1.92, P = 0.07, CI: [−0.008–0.17], Cohen’s d = 0.45).
In support of this, Pol II signals showed a trend of increase at two of these enhancers ( p = 0.07–0.08) in response to FC (Supplementary Fig. 7a-c ), which are consistent with the earlier findings 16 ; although the Pol II difference between WT and Top3β-KO mice was not significant.
Moreover, we observed a marginally significant ( p = 0.07, Mann–Whitney test) difference in the number of DRMs of NS3-specific DAAs (4–10) and multi-protein DAAs (8–16).
ETV score was only a marginally significant predictor of prison violations after impression sensitivity and trust behavior were accounted for (direct effect = 0.622 ± 0.340, p = 0.070).
6e ), however, in adult mice there was a slight trend for higher apoptosis in newly generated oligodendrocytes in hM3Dq/GFP mice compared to controls ( P = 0.07, n = 4 mice, Welch’s corrected t -test; Supplementary Fig. 6f-h ).
In addition, correlation analysis of the dataset revealed a positive trend between Bmal1 and Dpp4 expression across time points (r2=0.142, P = 0.070).
Four transporter activity GO terms, including ion channel activity, cation channel activity, substrate-specific channel activity, and cation transmembrane transporter activity, had borderline significant associations with lung cancer (Fisher’s exact test, P = 0.071, 0.073, 0.080, and 0.098, respectively) (Table 4 and Fig. 2 ).
For LUZP4, differences between seminoma and nonseminoma were more pronounced in ELISA (mean difference = 0.863, t = 3.658, p < 0.001), while phage-based detection approached significance ( t = 1.912, p = 0.071).
SC3 inhibitory activity became non-significant with the double mutation although the decrease in Vmax was close to significance ( p = 0.071), suggesting that SC3 may have some activity on the double mutant Drp1.
2C ), and showed a trend towards greater activity in the no-boating treatment ( t 20.0 = 1.91, p = 0.071; Fig. 2D ).
A regression analysis showed a trend for the τ decay to be inversely related with the increase in γ (Fig. 2r ; p = 0.0712, F (1,21) = 3.61).
Consistently, dietary supplementation of ARA to T.mu -free Blt1 −/− mice showed a trend toward increased serum anti-OVA IgA ( p = 0.0714) but failed to increase mucosal anti-OVA IgA levels (Supplementary Fig.
Whereas overexpression of sirt5 in wild-type animals did not lead to a significant change in OCR, Sirt5 significantly increased the OCR in sucla2 mutant zebrafish ( p = 0.0067) and showed a trend towards increased basal respiration ( p = 0.0725) (Fig. 5a–c ).
A previous study in this site observed a small negative and only marginally significant effect ( P = 0.073) of plant diversity on yield, and this influence was driven mostly by herbicide application in barley monoculture treatment and not due to plant richness per se 39 .