Excerpts

For the 12 CIS patients that converted to RRMS during the study, multiple regression modeling of time to conversion resulted in a highly significant model (adjusted R 2 0.81, p = 0.006) when including baseline CSF levels of CXCL1, CXCL10, CXCL13, and NFL, and number of T2 lesions at baseline).

Nevertheless, pooling of data from the rs2296147 polymorphism showed a trend toward an increase in survival of disease with HR of 0.42 (TT vs CC: 95% CI = 0.23–0.78, P heterogeneity = 0.708, I 2 = 0.0%, P = 0.006; Figure 3 ).

The results were clearly significant ( F = 4.057, p = 0.006), indicating that there were significant differences in expression between the groups.

In multivariate Cox proportional hazard regression analysis with adjustment for cardiovascular risk factors we found this difference to be highly significant ( p = 0.006).

The SECA primary test for the overlap of associated effects, including all 144 SNP subsets, revealed more subsets than expected by chance showing at least nominally significant pleiotropy between endometriosis and endometrial cancer ( P = 6.0 × 10 −3 ): The pair of SNP subsets producing the minimum exact binomial test P ‐value for pleiotropy (endometriosis SNP subset with P ≤ 0.002 and endometrial cancer SNP subset with P ≤ 0.86) had P = 3.3 × 10 −4 .

Baseline demographic and clinical characteristics were well balanced between the SCDM-DHM group and the control group ( p > 0.05), with no statistically significant differences observed in terms of maternal age, birth weight, gestational age, number of males, delivery mode, SGA status, or length of hospital stay; a decreasing trend in the number of single births was observed in the SCDM-DHM group ( p = 0.006).

Survival curves revealed that miR-151b is able to discriminate between two groups of UTUC patients with a highly significant different probability of tumour progression (p=0.006) and cancer specific survival (p=0.034).

Although not robust to multiple corrections, resting state studies (11 studies) approached significance for negative binomial regression (0.56% foci increase per 10 subjects, p = 0.006) and Pearson correlation (r = 0.67, p = 0.012).

Evolution of usage in weaned piglets Antimicrobial usage in weaned pigs decreased between 2010 and 2013 (− 19% of nDD/animal), a highly significant result ( p = 0.006).

Omega-3 PUFAs Comparative analysis of omega-3 levels PUFAs between the Fst-Tg and WT adipose tissue metabolites display highly significant increase in two key PUFAs including docosapentaenoate (n3; 22:5n3) (1.42 fold; P =0.006), and docosahexaenoate (22:6n3) (1.5 fold; P =0.03) selectively in SC adipose tissues ( Table 3 ).

A highly significant difference in the level of variance was observed between the different assays (Levene’s test, F (2,27) = 6.3, P = 0.006, Fig. 4 ).

The interactions between DLI and endophyte inoculation on daily transpiration were highly significant ( P = 0.006).

As expected, there were no significant main effects of SEQUENCE [ F (1, 17) = 0.41, p = 0.531] or HEMISPHERE [ F (1, 17) = 0.08, p = 0.783]; however, the N100m activity was much larger in the hemisphere contralateral to the ear of entry, as revealed by a highly significant main effect of EAR OF ENTRY [ F (2, 34) = 7.16, p = 0.006 ** ] and a highly significant HEMISPHERE * EAR OF ENTRY interaction [ F (2, 34) = 27.18, p < 0.001 *** ].

Highly significant differences ( P ≤ 0.006) in the IgA/IgG ratios in serum and saliva samples were observed for antibodies to all 3 NTHi proteins, suggesting that IgG and IgA antibodies to these proteins are produced both systemically and mucosally.

The linear regression model explained 54.4% of the variance of ECAS‐Language scores ( F (19, 219) = 13.77; p < 0.001), with only the ECAS‐Executive positively predicting them at α adjusted = 0.0028 ( β = 0.46; t (219) = 5.97; p < 0.001; η 2 = 0.07), and a similar, although marginally significant, effect being found for ECAS‐Visuo‐spatial ( β = 0.15; t (219) = 2.78; p = 0.006; η 2 = 0.02).

Anti-α-synuclein ( b = 0.186; P = 0.048) was borderline significant, and α-synuclein/Aβ40 ( b = 0.015; P = 0.006) was the only significant biomarker for predicting cognitive impairment in PD group (M2; Table 4 ).

The average D-dimer level showed an increasing trend as the cell dose increased ( p = 0.006).

This relationship remained highly significant when adjusting for starting dose categorically (aHR = 1.717, 95% CI: 1.17, 2.52, P = .006) or continuously (aHR = 1.67, 95% CI: 1.14, 2.43, P = .008).

However, the correlation between HMGT score and level of education was highly significant (r=0.28, p=0.006).

Merging the ten subjects resulted in a highly significant improvement in SRT50 ( P = 0.006).

Notably, the expression of E-cadherin demonstrated a significant decline among the three groups ( P <0.001), whereas Vimentin exhibited an increasing trend ( P =0.006).

The Genotype-Tissue Expression (GTEx) database showed a significant trend for increased HFE expression in rs9393682 C allele carriers ( P = 0.006; Figure 2A ). rs9393682 and rs1378033 fall within putative VDREs, and may alter 1,25-VD-mediated gene regulation.

Subgroup analysis showed no significant age-related differences in males (P=0.389), but there was a highly significant difference in females (P=0.006), showing the higher prevalence of maxillary retrognathism in the 7-11-year-old female group.

As age increased, there was an increasing trend in the median ICU LOS (8.0 days vs. 9.0 days vs. 10.0 days; p = 0.006) and the proportion of transfers to long-term care hospital at the time of discharge (12.9% vs. 28.3% vs. 39.4%, p < 0.001).

Correlation between SE and measurement accuracy A correlation analysis between SE before each test and the measurement accuracy of the goniometric task of each test in the SC group revealed that SE before the STRT had a moderately significant negative correlation with the measurement accuracy of the STRT (ρ= -0.675, p = 0.006) (Fig. 5 a).