“showed a trend”

Furthermore, the ULK1 inhibitor SBI-0206965 showed a trend toward increasing tau puncta formation, whereas the ULK1 inhibitor XST-14 at 5 μM exacerbated intracellular p-tau aggregation but had no effect on degradation of preformed tau foci (Extended Data Fig. 10a,b ).

Consistent with these data, anti-C3a antibody treatment of aged mice significantly lowered IL-1β and monocyte chemoattractant protein 1 (MCP-1), whereas IL-6 showed a trend of reduction and TNF remained unchanged (Fig. 6g−i and Extended Data Fig. 8c ).

Note that chondroprogenitor cells in the SF zone of adult articular cartilage at P65, which exhibited reduced Ldha fluorescence levels, also showed a trend toward the lowest median fluorescence levels of Cs and pPdh ( Figures 3(B) , 4(B) and ( C )).

By 12 weeks, the HA group showed a trend toward increased bone formation compared to the Empty control group, although this was not statistically significant.

Notably, in an OF test, we confirmed that the anxiolytic doses of NPS retained a stimulatory effect in msPs, while the number of open arms entries and the distance travelled in the EPM showed a trend toward decreasing.

Carriers of the A1 allele of the Taq1A polymorphism (linked to the DRD2/ANKK1 locus), associated with reduced D2/3 receptor density, show higher risk for AUD; in an Indian male cohort, the A1 allele showed a trend toward association and a haplotype including A1 conferred an approximately 2.5-fold higher risk ( 146 ).

Overall, all HF subtypes showed a trend of decreased α diversity, but the degree of decrease differed: the decrease in gut microbiota diversity was most significant in HFrEF patients, while it was relatively mild in HFpEF ( Luedde et al., 2017 ; Beale et al., 2021 ).

Smokers experienced a significant improvement in OS, while non-smokers did not benefit even showed a trend towards deterioration.

In particular, false negative PD patients showed a trend toward higher NMSS scores and significantly greater autonomic and urinary burden than true-positive patients.

FcγRIIA-binding antibodies showed a trend toward enrichment for ARCT-154 recipients at the day 29–91 interval, with a few Spikes showing statistical significance compared to BNT162B2 recipients, but not nearly to the same degree as FcγRIIIA (Supplementary Fig. 6 ).

nucleatum- detectable cases also showed a trend toward increased T: A→A: T substitutions over F. nucleatum -undetectable cases (21.4% vs. 8.2%), although this association did not reach statistical significance ( P = 0.06, Table 2 , Supplementary Fig. 2).

For stage II and III patients, most of whom underwent mastectomy, postoperative radiotherapy showed a trend toward improved survival, but did not achieve statistical significance.

Notably, adults aged 40 to 59 years showed a trend reversal post-2007, with increases following a prior nonsignificant decline.

The addition of biomarkers to clinical variables showed a trend towards improvement in model performance, although this trend only met statistical significance for all-cause mortality in incident AF.

Lonner and co-workers noted that polyaxial constructs were associated with better maintenance of thoracic kyphosis compared with monoaxial or hybrid constructs, which showed a trend toward kyphosis loss; this observation highlights that the effect of screw type may be parameter-specific (i.e., affecting rotation or sagittal contours more than coronal Cobb correction) [ 9 ].

Age showed a trend toward increased risk but did not reach statistical significance.

However, AMD eyes showed a trend toward faster systemic diffusion, likely reflecting BRB disruption and neovascularization.

In contrast, although the 50-group showed a trend toward increased IFN-γ secretion, the response was not significantly different from unstimulated controls (Fig. 7 c), suggesting a weaker T cell response.

Nevertheless, even distal occlusions showed a trend towards higher disability with longer PT, highlighting that rapid reperfusion is advantageous across all occlusion sites.

Decorin expression showed a trend toward lower expression, but this difference was not statistically significant. 3.4.

In addition, a GWAS in Han Chinese children identified a significant association between estrogen receptor (ESR) polymorphisms and ADHD susceptibility, [ 40 ] the ESR1 variant rs6930355 showed a trend towards association in females.

CONCLUSION Although not statistically significant, iliac vein stenting in patients with chronic DVT showed a trend toward lower primary and secondary patency compared with acute DVT and NIVL.

Overall, 0.05% CsA eye drops were associated with improved tear film quality and stability after vitrectomy for DMDES, showed a trend of better relative improvement compared to SH eye drops. ciclosporin diabetes mellitus dry eye disease sodium hyaluronate vitrectomy The author(s) declared that financial support was received for this work and/or its publication.

Consistent with this, the multivariable logistic regression analysis ( Figure 4E ) indicated that neither SBP nor baseline NIHSS were independent predictors of sICH in this particular sample, although male sex showed a trend toward increased risk (OR 2.22, 95% CI 0.96–5.79) without reaching statistical significance.

In addition, elevated FC levels showed a trend toward an association with a newly established SpA diagnosis.